Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 21, 2003, Pages 3821-3825

  Lin, Nan Horng ^a   Wang, Le ^a   Cohen, Jerry ^a   Gu, Wen Zhen ^a   Frost, David ^a   Zhang, Haiying ^a   Rosenberg, Saul ^a   Sham, Hing ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(3 METHYL 3H IMIDAZOL 4 YL)(2 PHENYLETHYNYLBENZYLOXY)METHYL]BENZONITRILE; 4 [3 BIPHENYL 1 HYDROXY 1 (3 METHYL 3H IMIDAZOL 4 YL)PROP 2 YNYL] 1 YLBENZOLNITRILE; ANTINEOPLASTIC AGENT; IMIDAZOLE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE K RAS;

EID: 0141545067     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.07.006     Document Type: Article

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