Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and α-adrenolytic activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 3994-4003

  Kulig, Katarzyna ^a   Sapa, Jacek ^a   Nowaczyk, Alicja ^b   Filipek, Barbara ^a   Malawska, Barbara ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

Adrenoceptors blocking activity; 3,3 Diphenylpyrrolidin 2 one derivatives; Antiarrhythmic; Hypotensive activity

Indexed keywords

1 [2 HYDROXY 3 (4 PHENYLPIPERAZIN 1 YL)PROPYL] 3,3 DIPHENYLPYRROLIDIN 2 ONE; 1 [2 HYDROXY 3 [4 (2 METHYLPHENYL)PIPERAZIN 1 YL]PROPYL] 3,3 DIPHENYLPYRROLIDIN 2 ONE; 1 [2 HYDROXY 3 [4 (2 TRIFLUOROMETHYLPHENYL)PIPERAZIN 1 YL]PROPYL] 3,3 DIPHENYLPYRROLIDIN 2 ONE; 1 [2 HYDROXY 3 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]PROPYL] 3,3 DIPHENYLPYRROLIDIN 2 ONE; 1 [2 HYDROXY 3 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 3,3 DIPHENYLPYRROLIDIN 2 ONE; 1 [3 [4 (2 ETHOXYPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 3,3 DIPHENYLPYRROLIDIN 2 ONE; 1 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL] 2 HYDROXYPROPYL] 3,3 DIPHENYLPYRROLIDIN 2 ONE; 3,3 DIPHENYLPYRROLIDIN 2 ONE DERIVATIVE; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; PIPERAZINE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ARRHYTHMIA; HYPERTENSION; MALE; NONHUMAN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADRENERGIC ANTAGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTIHYPERTENSIVE AGENTS; ARRHYTHMIAS, CARDIAC; BLOOD PRESSURE; GUINEA PIGS; MALE; MODELS, MOLECULAR; PIPERAZINES; PROTEIN BINDING; PYRROLIDINONES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67651154141     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.028     Document Type: Article

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