Pharmacophore-based design, synthesis, biological evaluation, and 3D-QSAR studies of aryl-piperazines as α1-adrenoceptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 13, 2005, Pages 3216-3219

  Li, Min Yong ^a   Fang, Hao ^b   Xia, Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

1 Adrenoceptor; 3D QSAR; Antagonists; Pharmacophore based design

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; PIPERAZINE DERIVATIVE; PRAZOSIN;

ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; PHARMACOPHORE; PROSTATE HYPERTROPHY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TREATMENT INDICATION;

ADRENERGIC ALPHA-ANTAGONISTS; DATABASES, FACTUAL; DRUG DESIGN; HUMANS; MALE; PIPERAZINES; PRAZOSIN; PROSTATIC HYPERPLASIA; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, ADRENERGIC, ALPHA-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20444418658     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.003     Document Type: Article

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