Synthesis, antirrhythmic, antihypertensive, and α-adrenoceptor blocking activity of novel 1-[(2-hydroxy-3-amino)]-propylpyrrolidin-2-one derivatives

Archiv der Pharmazie

Volumn 330, Issue 7, 1997, Pages 225-231

  Filipek, Barbara ^a   Sapa, Jacek ^a   Malawska, Barbara ^a   Kulig, Katarzyna ^a   Antkiewicz Michaluk, Lucyna ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Adrenoceptors blocking activity; Antiarrhythmic; Antihypertensive; Phenylpiperazine pyrrolidine 2 one and pyrrolidine derivatives

Indexed keywords

2 PYRROLIDONE DERIVATIVE; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; PRAZOSIN; ANTIARRHYTHMIC AGENT; ANTIHYPERTENSIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ELECTROCARDIOGRAM; HEART RATE; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; ANIMAL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTIHYPERTENSIVE AGENTS; PYRROLIDINONES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031181243     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19973300707     Document Type: Article

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