In vitro and in vivo uroselectivity of B8805-033, an antagonist with high affinity at prostatic α1A- vs. α1B- and α1D-adrenoceptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 363, Issue 6, 2001, Pages 649-662

  Eltze, Manfrid ^a   Boer, Rainer ^a   Michel, Martin C ^b   Hein, Peter ^b   Testa, Rodolfo ^c   Ulrich, Wolf Rüdiger ^a   Kolassa, Norbert ^a   Sanders, Karl H ^a  

^a Research Departments   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c Recordati SpA   (Italy)

Author keywords

1 Adrenoceptor subtypes; B8805 033; Benign prostatic hyperplasia; Uroselectivity

Indexed keywords

1,3,5 TRIMETHYL 6 [[3 [4 [(2,3 DIHYDRO 2 HYDROXYMETHYL) 1,4 BENZODIOXIN 5 YL] 1 PIPERAZINYL]PROPYL]AMINO] 2,4(1H,3H) PYRIMIDINEDIONE; ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; HISTAMINE H1 RECEPTOR; NEUROTRANSMITTER RECEPTOR; NORADRENALIN; PRAZOSIN; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOG; DRUG INHIBITION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GUINEA PIG; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MOUSE; NONHUMAN; PROSTATE HYPERTROPHY; RABBIT; RAT; RECEPTOR AFFINITY;

ADRENERGIC ALPHA-ANTAGONISTS; ADULT; ANIMALS; BINDING, COMPETITIVE; BRAIN; CHO CELLS; CRICETINAE; DIOXINS; DOGS; HUMANS; LIVER; MALE; MICE; MUSCLE, SMOOTH, VASCULAR; PROSTATE; PROSTATIC HYPERPLASIA; PYRIMIDINONES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA; SPECIES SPECIFICITY; SWINE;

EID: 0035015981     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100100413     Document Type: Article

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