Hypothermic inhibition of apoptotic pathways for combined neurotoxicity of iron and ascorbic acid in differentiated PC12 cells: Reduction of oxidative stress and maintenance of the glutathione redox state

Brain Research

Volumn 1283, Issue , 2009, Pages 1-13

  Hasegawa, Masashi ^a   Ogihara, Tohru ^a   Tamai, Hiroshi ^a   Hiroi, Mayo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Glutathione; Hypothermia; Hypoxic ischemic encephalopathy; Iron, Ascorbic acid; Mitochondrial transmembrane potential

Indexed keywords

3 (2 HYDROXYPHENYL)ALANINE; 4 HYDROXYNONENAL; APOPTOSIS INDUCING FACTOR; ASCORBIC ACID; CASPASE 3; CYTOCHROME C; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROXYNONENAL; IRON; META TYROSINE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; INDUCED HYPOTHERMIA; LIPID PEROXIDATION; LOW TEMPERATURE; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROTOXICITY; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; TEMPERATURE SENSITIVITY;

ALDEHYDES; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ASCORBIC ACID; BIOLOGICAL MARKERS; BODY TEMPERATURE; DRUG SYNERGISM; GLUTATHIONE; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; IRON; MEMBRANE POTENTIALS; NEURONS; NEUROTOXINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; TEMPERATURE; TYROSINE;

EID: 67651120126     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.06.016     Document Type: Article

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