Non-protein-bound transition metals and hydroxyl radical generation in cerebrospinal fluid of newborn infants with hypoxic ischemic encephalopathy

Pediatric Research

Volumn 53, Issue 4, 2003, Pages 594-599

  Ogihara, Tohru ^a   Hirano, Kazuya ^a   Ogihara, Hiromi ^a   Misaki, Kiryo ^a   Hiroi, Mayo ^a   Morinobu, Takao ^a   Kim, Han Suk ^a   Ogawa, Satoru ^a   Ban, Ryoichi ^a   Hasegawa, Masashi ^a   Tamai, Hiroshi ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 HYDROXYPHENYL)ALANINE; AMINO ACID; COPPER; HYDROXYL RADICAL; IRON; META TYROSINE; METAL ION; PHENYLALANINE; REACTIVE OXYGEN METABOLITE; TRANSITION ELEMENT;

ARTICLE; BRAIN ISCHEMIA; CATALYSIS; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID EXAMINATION; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INFANT; IRON CHELATION; MALE; NEUROPROTECTION; OXIDATION; PERINATAL ASPHYXIA; PRIORITY JOURNAL;

ALLANTOIN; ASCORBIC ACID; BIOLOGICAL MARKERS; COPPER; DEHYDROASCORBIC ACID; FEMALE; HUMANS; HYDROXYL RADICAL; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; IRON; MALE; OXIDATIVE STRESS; PROTEIN BINDING; REACTIVE OXYGEN SPECIES;

EID: 0037385067     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000054685.87405.59     Document Type: Article

References (37)

1. Fellman V, Raivio KO 1997 Reperfusion injury as the mechanism of brain damage after perinatal asphyxia. Pediatr Res 41:599-606
2. Buonocore G, Perrone S, Bracci R 2001 Free radicals and brain damage in the newborn. Biol Neonate 79:180-189
3. Halliwell B, Gutteridge JMC 1990 Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186:1-85
4. Siesjo BK 1988 Acidosis and ischemic brain damage. Neurochem Pathol 9:31-88
5. Evans PJ, Evans R, Kovar IZ, Holton AF, Halliwell B 1992 Bleomycin-detectable iron in the plasma of premature and full-term neonates. FEBS Lett 303:210-212
6. Moison RMW, Palinckx JJS, Roest M, Houdkamp E, Berger HM 1993 Induction of lipid peroxidation of pulmonary surfactant by plasma of preterm babies. Lancet 341:79-82
7. Hirano K, Morinobu T, Kim HS, Hiroi M, Ban R, Ogawa S, Ogihara H, Tamai H, Ogihara T 2001 Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants. Arch Dis Child Fetal Neonatal Ed 84:F188-F193
8. Dorrepaal CA, Berger HM, Benders MJNL, Van Zoeren-Grobben D, Van De Bor M, Van Bel F 1996 Non-protein-bound iron in postasphyxial reperfusion injury of the newborn. Pediatrics 98:883-889
9. Halliwell B 1992 Reactive oxygen species and the central nervous system. J Neurochem 59:1609-1623
10. Savman K, Nilsson UA, Blennow M, Kjellmer I, Whitelaw A 2001 Non-protein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilatation. Pediatr Res 49:208-212
11. Palmer C, Roberts RL, Bero C 1994 Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 25:1039-1045
12. +-ATPase activity of cortical brain cell membrane during early reperfusion after hypoxia-ischemia in newborn lambs. Pediatr Res 48:560-564
13. Grünewald RA 1993 Ascorbic acid in the brain. Brain Res Brain Res Rev 18:123-133
14. Oriot D, Bétrémieux P, Baumann N, Lefrançois C, Le Marec B 1992 CSF ascorbic acid and lactate levels after neonatal asphyxia: preliminary results. Acta Paediatr 81:845-846
15. Halliwell B 1996 Vitamin C: antioxidant or pro-oxidant in vivo? Free Radic Res 25:439-454
16. Ogihara T, Kim HS, Hirano K, Imanishi M, Ogihara H, Tamai H, Okamoto R, Mino M 1998 Oxidation products of uric acid and ascorbic acid in preterm infants with chronic lung disease. Biol Neonate 73:24-33
17. Morrow JD, Roberts LJ 1997 The isoprostanes: unique bioactive products of lipid peroxidation. Prog Lipid Res 36:1-21
18. Ishimitsu S, Fujimoto S, Ohta A 1984 Studies on the hydroxylation of phenylalanine by 6,7-dimethyl-5,6,7,8-tetrahydropteridine. Chem Pharm Bull (Tokyo) 32:752-756
19. Karam LM, Bergtold DS, Simic MG 1991 Biomarkers of OH radical damage in vivo. Free Radic Res Commun 12:11-16
20. Saugstad OD 1988 Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res 23:143-150
21. Garcia-Alix A, Cabañas F, Pellicer A, Hernanz A, Stiris TA, Quero J 1994 Neuron-specific enolase and myelin basic protein: relationship of cerebrospinal fluid concentrations to the neurologic condition of asphyxiated full-term infants. Pediatrics 93:234-240
22. Roldán A, Figueras-Aloy J, Deulofeu R, Jiménez R 1999 Glycine and other neurotransmitter amino acids in cerebrospinal fluid in perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy. Acta Paediatr 88:1137-1141
23. Sarnat HB, Sarnat MS 1976 Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol 33:696-705
24. Gutteridge JMC, Rowley DA, Halliwell B 1981 Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts: Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA. Biochem J 199:263-265
25. Gutteridge JMC 1984 Copper-phenanthroline-induced site-specific oxygen-radical damage to DNA. Detection of loosely bound trace copper in biological fluids. Biochem J 218:983-985
26. Leeuwenburgh C, Rasmussen JE, Hsu FF, Mueller DM, Pennathur S, Heinecke JW 1997 Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques. J Biol Chem 272:3520-3526
27. Mawhinney TP, Robinett RSR, Atalay A, Madson MA 1986 Analysis of amino acids as their tert-butyldimethylsilyl derivatives by gas-liquid chromatography and mass spectrometry. J Chromatogr 358:231-242
28. Ogihara T, Okamoto R, Kim HS, Nagai A, Morinobu T, Moji H, Kamegai M, Hirano K, Ogihara H, Tamai H, Mino M 1996 New evidence for the involvement of oxygen radicals in triggering neonatal chronic lung disease. Pediatr Res 39:117-119
29. Harkness RA 1988 Hypoxanthine, xanthine and uridine in body fluids, indicators of ATP depletion. J Chromatogr 429:255-278
30. Gutteridge JMC 1991 Plasma ascorbate levels and inhibition of the antioxidant activity of caeruloplasmin. Clin Sci 81:413-417
31. Buettner GR 1993 The pecking order of free radicals and antioxidants: lipid peroxidation, α-tocopherol, and ascorbate. Arch Biochem Biophys 300:535-543
32. Janáky R, Ogita K, Pasqualotto BA, Bains JS, Oja SS, Yoneda Y, Shaw CA 1999 Glutathione and signal transduction in the mammalian CNS. J Neurochem 73:889-902
33. Gutteridge JMC 1992 Ferrous ions detected in cerebrospinal fluid by using bleomycin and DNA damage. Clin Sci 82:315-320
34. Halliwell B, Zhao K, Whiteman M 1999 Nitric oxide and peroxynitrite. The ugly, the uglier and the not so good: a personal view of recent controversies. Free Radic Res 31:651-669
35. Gutteridge JMC 1992 Iron and oxygen radicals in brain. Ann Neurol 32:S16-S21
36. Minotti G, Aust SD 1992 Redox cycling of iron and lipid peroxidation. Lipids 27:219-226
37. Vilanova JM, Figueras-Aloy J, Rosello J, Gomez G, Gelpi E, Jimenez R 1998 Arachidonic acid metabolites in CSF in hypoxic-ischaemic encephalopathy of newborn infants. Acta Paediatr 87:588-592