A model of the cell-autonomous mammalian circadian clock

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 27, 2009, Pages 11107-11112

  Mirsky, Henry P ^a   Liu, Andrew C ^b,c,d   Welsh, David K ^b,e,f   Kay, Steve A ^b   Doyle III, Francis J ^a,g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^d UNIVERSITY OF MEMPHIS   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^g University of California   (United States)

Author keywords

Cell level model; Evolutionary strategy; Gene regulatory network; Mathematical model; Mouse

Indexed keywords

ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; EUKARYOTE; MAMMAL CELL; MATHEMATICAL MODEL; MOLECULAR CLOCK; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROKARYOTE; SENSITIVITY ANALYSIS; ANIMAL; BIOLOGICAL MODEL; BIOLOGICAL RHYTHM; GENE EXPRESSION REGULATION; GENETICS; KINETICS; MAMMAL; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; REPRODUCIBILITY; TIME;

EUKARYOTA; MAMMALIA; MUS; PROKARYOTA;

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CELL CYCLE PROTEIN; CRYPTOCHROME; FLAVOPROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; PER2 PROTEIN, MOUSE; PROTEIN BMAL1; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL CLOCKS; CELL CYCLE PROTEINS; CIRCADIAN RHYTHM; FLAVOPROTEINS; GENE EXPRESSION REGULATION; KINETICS; MAMMALS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PHENOTYPE; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 67651115789     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904837106     Document Type: Article

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