-
1
-
-
0038607068
-
A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor
-
Ancey C., Küster A., Haan S., Herrmann A., Heinrich P.C., and Müller-Newen G. A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor. J. Biol. Chem. 278 (2003) 16968-16972
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16968-16972
-
-
Ancey, C.1
Küster, A.2
Haan, S.3
Herrmann, A.4
Heinrich, P.C.5
Müller-Newen, G.6
-
2
-
-
0025730640
-
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
-
Andrews N.C., and Faller D.V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19 (1991) 2499
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 2499
-
-
Andrews, N.C.1
Faller, D.V.2
-
3
-
-
0025859083
-
Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector
-
Arcone R., Pucci P., Zappacosta F., Fontaine V., Malorni A., Marino G., and Ciliberto G. Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector. Eur. J. Biochem. 198 (1991) 541-547
-
(1991)
Eur. J. Biochem.
, vol.198
, pp. 541-547
-
-
Arcone, R.1
Pucci, P.2
Zappacosta, F.3
Fontaine, V.4
Malorni, A.5
Marino, G.6
Ciliberto, G.7
-
4
-
-
45749101727
-
Induction and effector functions of T(H)17 cells
-
Bettelli E., Korn T., Oukka M., and Kuchroo V.K. Induction and effector functions of T(H)17 cells. Nature 453 (2008) 1051-1057
-
(2008)
Nature
, vol.453
, pp. 1051-1057
-
-
Bettelli, E.1
Korn, T.2
Oukka, M.3
Kuchroo, V.K.4
-
5
-
-
0038609651
-
Hexameric structure and assembly of the interleukin-6/IL-6a-receptor/gp130 complex
-
Boulanger M.J., Chow D., Brevnova E.E., and Garcia K.C. Hexameric structure and assembly of the interleukin-6/IL-6a-receptor/gp130 complex. Science 300 (2003) 2101-2104
-
(2003)
Science
, vol.300
, pp. 2101-2104
-
-
Boulanger, M.J.1
Chow, D.2
Brevnova, E.E.3
Garcia, K.C.4
-
6
-
-
0037231664
-
Cytokine traps: multi-component, high-affinity blockers of cytokine action
-
Economides A.N., Carpenter L.R., Rudge J.S., Wong V., Koehler-Stec E.M., Hartnett C., Pyles E.A., Xu X., Daly T.J., Young M.R., et al. Cytokine traps: multi-component, high-affinity blockers of cytokine action. Nat. Med. 9 (2003) 47-52
-
(2003)
Nat. Med.
, vol.9
, pp. 47-52
-
-
Economides, A.N.1
Carpenter, L.R.2
Rudge, J.S.3
Wong, V.4
Koehler-Stec, E.M.5
Hartnett, C.6
Pyles, E.A.7
Xu, X.8
Daly, T.J.9
Young, M.R.10
-
7
-
-
0034768777
-
Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts
-
Fehrenbach H., Weiskirchen R., Kasper M., and Gressner A.M. Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts. Hepatology 34 (2001) 943-952
-
(2001)
Hepatology
, vol.34
, pp. 943-952
-
-
Fehrenbach, H.1
Weiskirchen, R.2
Kasper, M.3
Gressner, A.M.4
-
8
-
-
0033012077
-
Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis
-
Goldenberg M.M. Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin. Ther. 21 (1999) 75-87
-
(1999)
Clin. Ther.
, vol.21
, pp. 75-87
-
-
Goldenberg, M.M.1
-
9
-
-
0037987019
-
The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes
-
Grötzinger J., Kurapkat G., Wollmer A., Kalai M., and Rose-John S. The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes. Proteins 27 (1997) 96-109
-
(1997)
Proteins
, vol.27
, pp. 96-109
-
-
Grötzinger, J.1
Kurapkat, G.2
Wollmer, A.3
Kalai, M.4
Rose-John, S.5
-
10
-
-
48449102092
-
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation
-
Hansen G., Hercus T.R., McClure B.J., Stomski F.C., Dottore M., Powell J., Ramshaw H., Woodcock J.M., Xu Y., Guthridge M., et al. The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell 134 (2008) 496-507
-
(2008)
Cell
, vol.134
, pp. 496-507
-
-
Hansen, G.1
Hercus, T.R.2
McClure, B.J.3
Stomski, F.C.4
Dottore, M.5
Powell, J.6
Ramshaw, H.7
Woodcock, J.M.8
Xu, Y.9
Guthridge, M.10
-
11
-
-
0041677606
-
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
-
Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Müller-Newen G., and Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374 (2003) 1-20
-
(2003)
Biochem. J.
, vol.374
, pp. 1-20
-
-
Heinrich, P.C.1
Behrmann, I.2
Haan, S.3
Hermanns, H.M.4
Müller-Newen, G.5
Schaper, F.6
-
12
-
-
0028075945
-
Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction
-
Hilton D.J., Hilton A.A., Raicevic A., Rakar S., Harrison-Smith M., Gough N.M., Begley C.G., Metcalf D., Nicola N.A., and Willson T.A. Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 13 (1994) 4765-4775
-
(1994)
EMBO J.
, vol.13
, pp. 4765-4775
-
-
Hilton, D.J.1
Hilton, A.A.2
Raicevic, A.3
Rakar, S.4
Harrison-Smith, M.5
Gough, N.M.6
Begley, C.G.7
Metcalf, D.8
Nicola, N.A.9
Willson, T.A.10
-
13
-
-
0028897161
-
The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor
-
Horsten U., Schmitz-Van de Leur H., Müllberg J., Heinrich P.C., and Rose-John S. The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor. FEBS Lett. 360 (1995) 43-46
-
(1995)
FEBS Lett.
, vol.360
, pp. 43-46
-
-
Horsten, U.1
Schmitz-Van de Leur, H.2
Müllberg, J.3
Heinrich, P.C.4
Rose-John, S.5
-
14
-
-
0036694589
-
IL-6 in autoimmune disease and chronic inflammatory proliferative disease
-
Ishihara K., and Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13 (2002) 357-368
-
(2002)
Cytokine Growth Factor Rev.
, vol.13
, pp. 357-368
-
-
Ishihara, K.1
Hirano, T.2
-
15
-
-
46249087566
-
An interleukin-6-neutralizing antibody prevents cyclosporine-induced nephrotoxicity in mice
-
LaSpina M., Tripathi S., Gatto L.A., Bruch D., Maier K.G., and Kittur D.S. An interleukin-6-neutralizing antibody prevents cyclosporine-induced nephrotoxicity in mice. J. Surg. Res. 148 (2008) 121-125
-
(2008)
J. Surg. Res.
, vol.148
, pp. 121-125
-
-
LaSpina, M.1
Tripathi, S.2
Gatto, L.A.3
Bruch, D.4
Maier, K.G.5
Kittur, D.S.6
-
16
-
-
6344268944
-
Mechanisms of soluble cytokine receptor generation
-
Levine S.J. Mechanisms of soluble cytokine receptor generation. J. Immunol. 173 (2004) 5343-5348
-
(2004)
J. Immunol.
, vol.173
, pp. 5343-5348
-
-
Levine, S.J.1
-
17
-
-
0026475047
-
High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo
-
Lu Z.Y., Brochier J., Wijdenes J., Brailly H., Bataille R., and Klein B. High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo. Eur. J. Immunol. 22 (1992) 2819-2824
-
(1992)
Eur. J. Immunol.
, vol.22
, pp. 2819-2824
-
-
Lu, Z.Y.1
Brochier, J.2
Wijdenes, J.3
Brailly, H.4
Bataille, R.5
Klein, B.6
-
18
-
-
33847701356
-
Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins
-
Metz S., Wiesinger M., Vogt M., Lauks H., Schmalzing G., Heinrich P.C., and Müller-Newen G. Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins. J. Biol. Chem. 282 (2007) 1238-1248
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 1238-1248
-
-
Metz, S.1
Wiesinger, M.2
Vogt, M.3
Lauks, H.4
Schmalzing, G.5
Heinrich, P.C.6
Müller-Newen, G.7
-
19
-
-
44449165636
-
Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors
-
Metz S., Naeth G., Heinrich P.C., and Müller-Newen G. Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors. J. Biol. Chem. 283 (2008) 5985-5995
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 5985-5995
-
-
Metz, S.1
Naeth, G.2
Heinrich, P.C.3
Müller-Newen, G.4
-
20
-
-
0142168009
-
The cytokine receptor gp130: faithfully promiscuous
-
Müller-Newen G. The cytokine receptor gp130: faithfully promiscuous. Sci. STKE 2003 (2003) pe40
-
(2003)
Sci. STKE
, vol.2003
-
-
Müller-Newen, G.1
-
21
-
-
0038739858
-
Soluble interleukin-6 receptor potentiates the antagonistic activity of soluble gp130 on interleukin-6 responses
-
Müller-Newen G., Küster A., Hemmann U., Keul R., Horsten U., Martens A., Graeve L., Wijdenes J., and Heinrich P.C. Soluble interleukin-6 receptor potentiates the antagonistic activity of soluble gp130 on interleukin-6 responses. J. Immunol. 161 (1998) 6347-6355
-
(1998)
J. Immunol.
, vol.161
, pp. 6347-6355
-
-
Müller-Newen, G.1
Küster, A.2
Hemmann, U.3
Keul, R.4
Horsten, U.5
Martens, A.6
Graeve, L.7
Wijdenes, J.8
Heinrich, P.C.9
-
22
-
-
40649109728
-
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
-
Naugler W.E., and Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol. Med. 14 (2008) 109-119
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 109-119
-
-
Naugler, W.E.1
Karin, M.2
-
23
-
-
33646228126
-
Interleukin-6 trans-signalling in chronic inflammation and cancer
-
Scheller J., Ohnesorge N., and Rose-John S. Interleukin-6 trans-signalling in chronic inflammation and cancer. Scand. J. Immunol. 63 (2006) 321-329
-
(2006)
Scand. J. Immunol.
, vol.63
, pp. 321-329
-
-
Scheller, J.1
Ohnesorge, N.2
Rose-John, S.3
-
24
-
-
0037984291
-
Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF
-
Schuster B., Kovaleva M., Sun Y., Regenhard P., Matthews V., Grotzinger J., Rose-John S., and Kallen K.J. Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J. Biol. Chem. 278 (2003) 9528-9535
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9528-9535
-
-
Schuster, B.1
Kovaleva, M.2
Sun, Y.3
Regenhard, P.4
Matthews, V.5
Grotzinger, J.6
Rose-John, S.7
Kallen, K.J.8
-
25
-
-
33846240367
-
BCL-2 expression is mainly regulated by JAK/STAT3 pathway in human CD34+ hematopoietic cells
-
Sepulveda P., Encabo A., Carbonell-Uberos F., and Minana M.D. BCL-2 expression is mainly regulated by JAK/STAT3 pathway in human CD34+ hematopoietic cells. Cell Death Differ. 14 (2007) 378-380
-
(2007)
Cell Death Differ.
, vol.14
, pp. 378-380
-
-
Sepulveda, P.1
Encabo, A.2
Carbonell-Uberos, F.3
Minana, M.D.4
-
26
-
-
48249148236
-
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
-
Serada S., Fujimoto M., Mihara M., Koike N., Ohsugi Y., Nomura S., Yoshida H., Nishikawa T., Terabe F., Ohkawara T., et al. IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 105 (2008) 9041-9046
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 9041-9046
-
-
Serada, S.1
Fujimoto, M.2
Mihara, M.3
Koike, N.4
Ohsugi, Y.5
Nomura, S.6
Yoshida, H.7
Nishikawa, T.8
Terabe, F.9
Ohkawara, T.10
-
27
-
-
0031764389
-
The interactions of the cytokine-binding homology region and immunoglobulin-like domains of gp130 with oncostatin M: implications for receptor complex formation
-
Staunton D., Hudson K.R., and Heath J.K. The interactions of the cytokine-binding homology region and immunoglobulin-like domains of gp130 with oncostatin M: implications for receptor complex formation. Protein Eng. 11 (1998) 1093-1102
-
(1998)
Protein Eng.
, vol.11
, pp. 1093-1102
-
-
Staunton, D.1
Hudson, K.R.2
Heath, J.K.3
-
28
-
-
27144465484
-
Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels
-
Vaccaro C., Zhou J., Ober R.J., and Ward E.S. Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nat. Biotechnol. 23 (2005) 1283-1288
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1283-1288
-
-
Vaccaro, C.1
Zhou, J.2
Ober, R.J.3
Ward, E.S.4
-
29
-
-
18744394296
-
Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain
-
Varghese J.N., Moritz R.L., Lou M.Z., Van Donkelaar A., Ji H., Ivancic N., Branson K.M., Hall N.E., and Simpson R.J. Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain. Proc. Natl. Acad. Sci. USA 99 (2002) 15959-15964
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 15959-15964
-
-
Varghese, J.N.1
Moritz, R.L.2
Lou, M.Z.3
Van Donkelaar, A.4
Ji, H.5
Ivancic, N.6
Branson, K.M.7
Hall, N.E.8
Simpson, R.J.9
-
30
-
-
0033565363
-
A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding
-
Vollmer P., Oppmann B., Voltz N., Fischer M., and Rose-John S. A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding. Eur. J. Biochem. 263 (1999) 438-446
-
(1999)
Eur. J. Biochem.
, vol.263
, pp. 438-446
-
-
Vollmer, P.1
Oppmann, B.2
Voltz, N.3
Fischer, M.4
Rose-John, S.5
-
31
-
-
0025398721
-
WHAT IF: a molecular modeling and drug design program
-
Vriend G. WHAT IF: a molecular modeling and drug design program. J. Mol. Graph. 8 (1990) 52-56
-
(1990)
J. Mol. Graph.
, vol.8
, pp. 52-56
-
-
Vriend, G.1
-
32
-
-
0025639009
-
The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
-
Wagner B.J., Hayes T.E., Hoban C.J., and Cochran B.H. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9 (1990) 4477-4484
-
(1990)
EMBO J.
, vol.9
, pp. 4477-4484
-
-
Wagner, B.J.1
Hayes, T.E.2
Hoban, C.J.3
Cochran, B.H.4
-
33
-
-
0028274299
-
The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transduction and transcription (Stat) factor family
-
Wegenka U.M., Lütticken C., Buschmann J., Yuan J., Lottspeich F., Müller-Esterl W., Schindler C., Roeb E., Heinrich P.C., and Horn F. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transduction and transcription (Stat) factor family. Mol. Cell. Biol. 14 (1994) 3186-3196
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 3186-3196
-
-
Wegenka, U.M.1
Lütticken, C.2
Buschmann, J.3
Yuan, J.4
Lottspeich, F.5
Müller-Esterl, W.6
Schindler, C.7
Roeb, E.8
Heinrich, P.C.9
Horn, F.10
-
34
-
-
0037435011
-
Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway
-
Wei L.H., Kuo M.L., Chen C.A., Chou C.H., Lai K.B., Lee C.N., and Hsieh C.Y. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22 (2003) 1517-1527
-
(2003)
Oncogene
, vol.22
, pp. 1517-1527
-
-
Wei, L.H.1
Kuo, M.L.2
Chen, C.A.3
Chou, C.H.4
Lai, K.B.5
Lee, C.N.6
Hsieh, C.Y.7
-
35
-
-
0028793383
-
Soluble human interleukin-6 receptor: expression in insect cells, purification and characterization
-
Weiergräber O., Hemmann U., Küster A., Müller-Newen G., Schneider J., Rose-John S., Kurschat P., Brakenhoff J.P., Hart M.H., Stabel S., and Heinrich P.C. Soluble human interleukin-6 receptor: expression in insect cells, purification and characterization. Eur. J. Biochem. 234 (1995) 661-669
-
(1995)
Eur. J. Biochem.
, vol.234
, pp. 661-669
-
-
Weiergräber, O.1
Hemmann, U.2
Küster, A.3
Müller-Newen, G.4
Schneider, J.5
Rose-John, S.6
Kurschat, P.7
Brakenhoff, J.P.8
Hart, M.H.9
Stabel, S.10
Heinrich, P.C.11
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