메뉴 건너뛰기




Volumn 16, Issue 7, 2009, Pages 783-794

Development of an IL-6 Inhibitor Based on the Functional Analysis of Murine IL-6Rα1

Author keywords

CELLBIO; CHEMBIO; MOLIMMUNO

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; LIGAND;

EID: 67651114018     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2009.06.010     Document Type: Article
Times cited : (11)

References (35)
  • 1
    • 0038607068 scopus 로고    scopus 로고
    • A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor
    • Ancey C., Küster A., Haan S., Herrmann A., Heinrich P.C., and Müller-Newen G. A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor. J. Biol. Chem. 278 (2003) 16968-16972
    • (2003) J. Biol. Chem. , vol.278 , pp. 16968-16972
    • Ancey, C.1    Küster, A.2    Haan, S.3    Herrmann, A.4    Heinrich, P.C.5    Müller-Newen, G.6
  • 2
    • 0025730640 scopus 로고
    • A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
    • Andrews N.C., and Faller D.V. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19 (1991) 2499
    • (1991) Nucleic Acids Res. , vol.19 , pp. 2499
    • Andrews, N.C.1    Faller, D.V.2
  • 3
    • 0025859083 scopus 로고
    • Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector
    • Arcone R., Pucci P., Zappacosta F., Fontaine V., Malorni A., Marino G., and Ciliberto G. Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector. Eur. J. Biochem. 198 (1991) 541-547
    • (1991) Eur. J. Biochem. , vol.198 , pp. 541-547
    • Arcone, R.1    Pucci, P.2    Zappacosta, F.3    Fontaine, V.4    Malorni, A.5    Marino, G.6    Ciliberto, G.7
  • 4
    • 45749101727 scopus 로고    scopus 로고
    • Induction and effector functions of T(H)17 cells
    • Bettelli E., Korn T., Oukka M., and Kuchroo V.K. Induction and effector functions of T(H)17 cells. Nature 453 (2008) 1051-1057
    • (2008) Nature , vol.453 , pp. 1051-1057
    • Bettelli, E.1    Korn, T.2    Oukka, M.3    Kuchroo, V.K.4
  • 5
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6a-receptor/gp130 complex
    • Boulanger M.J., Chow D., Brevnova E.E., and Garcia K.C. Hexameric structure and assembly of the interleukin-6/IL-6a-receptor/gp130 complex. Science 300 (2003) 2101-2104
    • (2003) Science , vol.300 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.2    Brevnova, E.E.3    Garcia, K.C.4
  • 7
    • 0034768777 scopus 로고    scopus 로고
    • Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts
    • Fehrenbach H., Weiskirchen R., Kasper M., and Gressner A.M. Up-regulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts. Hepatology 34 (2001) 943-952
    • (2001) Hepatology , vol.34 , pp. 943-952
    • Fehrenbach, H.1    Weiskirchen, R.2    Kasper, M.3    Gressner, A.M.4
  • 8
    • 0033012077 scopus 로고    scopus 로고
    • Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis
    • Goldenberg M.M. Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin. Ther. 21 (1999) 75-87
    • (1999) Clin. Ther. , vol.21 , pp. 75-87
    • Goldenberg, M.M.1
  • 9
    • 0037987019 scopus 로고    scopus 로고
    • The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes
    • Grötzinger J., Kurapkat G., Wollmer A., Kalai M., and Rose-John S. The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes. Proteins 27 (1997) 96-109
    • (1997) Proteins , vol.27 , pp. 96-109
    • Grötzinger, J.1    Kurapkat, G.2    Wollmer, A.3    Kalai, M.4    Rose-John, S.5
  • 13
    • 0028897161 scopus 로고
    • The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor
    • Horsten U., Schmitz-Van de Leur H., Müllberg J., Heinrich P.C., and Rose-John S. The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor. FEBS Lett. 360 (1995) 43-46
    • (1995) FEBS Lett. , vol.360 , pp. 43-46
    • Horsten, U.1    Schmitz-Van de Leur, H.2    Müllberg, J.3    Heinrich, P.C.4    Rose-John, S.5
  • 14
    • 0036694589 scopus 로고    scopus 로고
    • IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    • Ishihara K., and Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13 (2002) 357-368
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 357-368
    • Ishihara, K.1    Hirano, T.2
  • 15
    • 46249087566 scopus 로고    scopus 로고
    • An interleukin-6-neutralizing antibody prevents cyclosporine-induced nephrotoxicity in mice
    • LaSpina M., Tripathi S., Gatto L.A., Bruch D., Maier K.G., and Kittur D.S. An interleukin-6-neutralizing antibody prevents cyclosporine-induced nephrotoxicity in mice. J. Surg. Res. 148 (2008) 121-125
    • (2008) J. Surg. Res. , vol.148 , pp. 121-125
    • LaSpina, M.1    Tripathi, S.2    Gatto, L.A.3    Bruch, D.4    Maier, K.G.5    Kittur, D.S.6
  • 16
    • 6344268944 scopus 로고    scopus 로고
    • Mechanisms of soluble cytokine receptor generation
    • Levine S.J. Mechanisms of soluble cytokine receptor generation. J. Immunol. 173 (2004) 5343-5348
    • (2004) J. Immunol. , vol.173 , pp. 5343-5348
    • Levine, S.J.1
  • 17
    • 0026475047 scopus 로고
    • High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo
    • Lu Z.Y., Brochier J., Wijdenes J., Brailly H., Bataille R., and Klein B. High amounts of circulating interleukin (IL)-6 in the form of monomeric immune complexes during anti-IL-6 therapy. Towards a new methodology for measuring overall cytokine production in human in vivo. Eur. J. Immunol. 22 (1992) 2819-2824
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2819-2824
    • Lu, Z.Y.1    Brochier, J.2    Wijdenes, J.3    Brailly, H.4    Bataille, R.5    Klein, B.6
  • 18
    • 33847701356 scopus 로고    scopus 로고
    • Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins
    • Metz S., Wiesinger M., Vogt M., Lauks H., Schmalzing G., Heinrich P.C., and Müller-Newen G. Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins. J. Biol. Chem. 282 (2007) 1238-1248
    • (2007) J. Biol. Chem. , vol.282 , pp. 1238-1248
    • Metz, S.1    Wiesinger, M.2    Vogt, M.3    Lauks, H.4    Schmalzing, G.5    Heinrich, P.C.6    Müller-Newen, G.7
  • 19
    • 44449165636 scopus 로고    scopus 로고
    • Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors
    • Metz S., Naeth G., Heinrich P.C., and Müller-Newen G. Novel inhibitors for murine and human leukemia inhibitory factor based on fused soluble receptors. J. Biol. Chem. 283 (2008) 5985-5995
    • (2008) J. Biol. Chem. , vol.283 , pp. 5985-5995
    • Metz, S.1    Naeth, G.2    Heinrich, P.C.3    Müller-Newen, G.4
  • 20
    • 0142168009 scopus 로고    scopus 로고
    • The cytokine receptor gp130: faithfully promiscuous
    • Müller-Newen G. The cytokine receptor gp130: faithfully promiscuous. Sci. STKE 2003 (2003) pe40
    • (2003) Sci. STKE , vol.2003
    • Müller-Newen, G.1
  • 22
    • 40649109728 scopus 로고    scopus 로고
    • The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
    • Naugler W.E., and Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol. Med. 14 (2008) 109-119
    • (2008) Trends Mol. Med. , vol.14 , pp. 109-119
    • Naugler, W.E.1    Karin, M.2
  • 23
    • 33646228126 scopus 로고    scopus 로고
    • Interleukin-6 trans-signalling in chronic inflammation and cancer
    • Scheller J., Ohnesorge N., and Rose-John S. Interleukin-6 trans-signalling in chronic inflammation and cancer. Scand. J. Immunol. 63 (2006) 321-329
    • (2006) Scand. J. Immunol. , vol.63 , pp. 321-329
    • Scheller, J.1    Ohnesorge, N.2    Rose-John, S.3
  • 24
    • 0037984291 scopus 로고    scopus 로고
    • Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF
    • Schuster B., Kovaleva M., Sun Y., Regenhard P., Matthews V., Grotzinger J., Rose-John S., and Kallen K.J. Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J. Biol. Chem. 278 (2003) 9528-9535
    • (2003) J. Biol. Chem. , vol.278 , pp. 9528-9535
    • Schuster, B.1    Kovaleva, M.2    Sun, Y.3    Regenhard, P.4    Matthews, V.5    Grotzinger, J.6    Rose-John, S.7    Kallen, K.J.8
  • 25
    • 33846240367 scopus 로고    scopus 로고
    • BCL-2 expression is mainly regulated by JAK/STAT3 pathway in human CD34+ hematopoietic cells
    • Sepulveda P., Encabo A., Carbonell-Uberos F., and Minana M.D. BCL-2 expression is mainly regulated by JAK/STAT3 pathway in human CD34+ hematopoietic cells. Cell Death Differ. 14 (2007) 378-380
    • (2007) Cell Death Differ. , vol.14 , pp. 378-380
    • Sepulveda, P.1    Encabo, A.2    Carbonell-Uberos, F.3    Minana, M.D.4
  • 27
    • 0031764389 scopus 로고    scopus 로고
    • The interactions of the cytokine-binding homology region and immunoglobulin-like domains of gp130 with oncostatin M: implications for receptor complex formation
    • Staunton D., Hudson K.R., and Heath J.K. The interactions of the cytokine-binding homology region and immunoglobulin-like domains of gp130 with oncostatin M: implications for receptor complex formation. Protein Eng. 11 (1998) 1093-1102
    • (1998) Protein Eng. , vol.11 , pp. 1093-1102
    • Staunton, D.1    Hudson, K.R.2    Heath, J.K.3
  • 28
    • 27144465484 scopus 로고    scopus 로고
    • Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels
    • Vaccaro C., Zhou J., Ober R.J., and Ward E.S. Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nat. Biotechnol. 23 (2005) 1283-1288
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1283-1288
    • Vaccaro, C.1    Zhou, J.2    Ober, R.J.3    Ward, E.S.4
  • 30
    • 0033565363 scopus 로고    scopus 로고
    • A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding
    • Vollmer P., Oppmann B., Voltz N., Fischer M., and Rose-John S. A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding. Eur. J. Biochem. 263 (1999) 438-446
    • (1999) Eur. J. Biochem. , vol.263 , pp. 438-446
    • Vollmer, P.1    Oppmann, B.2    Voltz, N.3    Fischer, M.4    Rose-John, S.5
  • 31
    • 0025398721 scopus 로고
    • WHAT IF: a molecular modeling and drug design program
    • Vriend G. WHAT IF: a molecular modeling and drug design program. J. Mol. Graph. 8 (1990) 52-56
    • (1990) J. Mol. Graph. , vol.8 , pp. 52-56
    • Vriend, G.1
  • 32
    • 0025639009 scopus 로고
    • The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
    • Wagner B.J., Hayes T.E., Hoban C.J., and Cochran B.H. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J. 9 (1990) 4477-4484
    • (1990) EMBO J. , vol.9 , pp. 4477-4484
    • Wagner, B.J.1    Hayes, T.E.2    Hoban, C.J.3    Cochran, B.H.4
  • 33
    • 0028274299 scopus 로고
    • The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transduction and transcription (Stat) factor family
    • Wegenka U.M., Lütticken C., Buschmann J., Yuan J., Lottspeich F., Müller-Esterl W., Schindler C., Roeb E., Heinrich P.C., and Horn F. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transduction and transcription (Stat) factor family. Mol. Cell. Biol. 14 (1994) 3186-3196
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3186-3196
    • Wegenka, U.M.1    Lütticken, C.2    Buschmann, J.3    Yuan, J.4    Lottspeich, F.5    Müller-Esterl, W.6    Schindler, C.7    Roeb, E.8    Heinrich, P.C.9    Horn, F.10
  • 34
    • 0037435011 scopus 로고    scopus 로고
    • Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway
    • Wei L.H., Kuo M.L., Chen C.A., Chou C.H., Lai K.B., Lee C.N., and Hsieh C.Y. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene 22 (2003) 1517-1527
    • (2003) Oncogene , vol.22 , pp. 1517-1527
    • Wei, L.H.1    Kuo, M.L.2    Chen, C.A.3    Chou, C.H.4    Lai, K.B.5    Lee, C.N.6    Hsieh, C.Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.