Evaluation of the hypothalamic-pituitary-adrenal axis function in childhood and adolescence

NeuroImmunoModulation

Volumn 16, Issue 5, 2009, Pages 272-283

  Chrousos, George P ^a,b   Kino, Tomoshige ^b   Charmandari, Evangelia ^a,b  

^a BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

CRH test; Dexamethasone suppression test; Glucocorticoids; Hypothalamic pituitary adrenal axis; Synacthen test

Indexed keywords

ARGIPRESSIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID; HYDROCORTISONE;

ADENOHYPOPHYSIS; ADRENAL CORTEX; ADRENAL FUNCTION; ADRENAL HYPERPLASIA; ADRENAL INSUFFICIENCY; ADRENAL TUMOR; ADRENARCHE; COMPUTER ASSISTED TOMOGRAPHY; CONGENITAL ADRENAL HYPERPLASIA; CORTICOTROPIN BLOOD LEVEL; CUSHING SYNDROME; DEXAMETHASONE SUPPRESSION TEST; DIFFERENTIAL DIAGNOSIS; GONADAL DISEASE; HORMONE DEFICIENCY; HORMONE RELEASE; HUMAN; HYPERTENSION; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN TOLERANCE TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PETROSAL SINUS SAMPLING; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; REVIEW; STEROID 21 MONOOXYGENASE DEFICIENCY; STEROID URINE LEVEL;

ADOLESCENT; CHILD; CLINICAL LABORATORY TECHNIQUES; DIAGNOSTIC TECHNIQUES, ENDOCRINE; ENDOCRINE SYSTEM DISEASES; GLUCOCORTICOIDS; HUMANS; HYPOTHALAMIC HORMONES; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; NEUROSECRETORY SYSTEMS; PITUITARY-ADRENAL FUNCTION TESTS; PITUITARY-ADRENAL SYSTEM;

EID: 67651111885     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000216185     Document Type: Review

References (66)

1. Habib KE, Gold PW, Chrousos GP: Neuro-endocrinology of stress. Endocrinol Metab Clin North Am 2001;30: 695-728.
2. Chrousos GP: Organization and integration of the endocrine system;in Sperling M (ed): Pediatric Endocrinology. Philadelphia, Saunders, 2002, pp 1-14.
3. Charmandari E, Tsigos C, Chrousos G: Endocrinology of the stress response. Annu Rev Physiol 2005;67:259-284.
4. Vale WW, Spiess S, Rivier C, Rivier J: Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotrophin and β-endorphin. Science 1981;213:1394-1397.
5. Gillies GE, Linton EA, Lowry PJ: Corticotro-pin-releasing activity of the new CRF is potentiated several times by vasopressin. Nature 1982;299: 355-357.
6. Horrocks PM, Jones AF, Ratcliffe WA, Holder G, White A, Holder R, Ratcliffe JG, London DR: Patterns of ACTH and cortisol pul-satility over twenty-four hours in normal males and females. Clin Endocrinol (Oxf) 1990;32: 127-134.
7. Iranmanesh A, Lizarralde G, Short D, Veldhuis JD: Intensive venous sampling paradigms disclose high frequency adrenocorti-cotropin release episodes in normal men. J Clin Endocrinol Metab 1990;71: 1276-1283.
8. Veldhuis JD, Iranmanesh A, Johnson ML, Lizarralde G: Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man. J Clin Endocrinol Metab 1990;71: 452-463.
9. Calogero AE, Norton JA, Sheppard BC, List-wak SJ, Cromack DT, Wall R, Jensen RT, Chrousos GP: Pulsatile activation of the hy-pothalamic-pituitary- adrenal axis during major surgery. Metabolism 1992;41:839-845.
10. Wallace WH, Crowne EC, Shalet SM, Moore C, Gibson S, Littley MD, White A: Episodic ACTH and cortisol secretion in normal children. Clin Endocrinol (Oxf) 1991;34:215-221.
11. Tannenbaum BM, Brindley DN, Tannen-baum GS, Dallman MF, McArthur MD, Meaney MJ: High-fat feeding alters both basal and stress-induced hypothalamic-pitu-itary-adrenal activity in the rat. Am J Physiol 1997;273:E1168-E1177.
12. Holmes MC, Antoni FA, Aguilera G, Catt KJ: Magnocellular axons in passage through the median eminence release vasopressin. Nature 1986;319: 326-329.
13. Miller WL, Johnson LK, Baxter JD, Roberts JL: Processing of the precursor to corticotropin and β-lipotropin in humans. Proc Natl Acad Sci USA 1980;77: 5211-5215.
14. Whitfeld PL, Seeburg PH, Shine J: The human pro-opiomelanocortin gene: organization, sequence, and interspersion with repetitive DNA. DNA 1982;1:133-143.
15. Lundblad JR, Roberts JL: Regulation of proopiomelanocortin gene expression in pituitary. Endocr Rev 1988;9: 135-158.
16. Andreis PG, Neri G, Mazzocchi G, Musajo F, Nussdorfer GG: Direct secretagogue effect of corticotropin-releasing factor on the rat adrenal cortex: the involvement of the zona medullaris. Endocrinology 1992;131:69-72.
17. Bornstein SR, Chrousos GP: Clinical review 104: Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: neural and immune inputs. J Clin Endocrinol Metab 1999;84: 1729-1736.
18. Bamberger CM, Schulte HM, Chrousos GP: Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 1996;17:245-261.
19. Schaaf MJ, Cidlowski JA: Molecular mechanisms of glucocorticoid action and resistance. J Steroid Biochem Mol Biol 2002;83: 37-48.
20. Zhou J, Cidlowski JA: The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids 2005;70: 407-417.
21. Duma D, Jewell CM, Cidlowski JA: Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification. J Steroid Biochem Mol Biol 2006;102:11-21.
22. Pratt WB: The role of heat-shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. J Biol Chem 1993;268: 21455-21458.
23. Terry LJ, Shows EB, Wente SR: Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport. Science 2007;318: 1412-1416.
24. Jonat C, Rahmsdorf HJ, Park KK, Cato AC, Gebel S, Ponta H, Herrlich P: Antitumor promotion and anti-inflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 1990;62: 1189-1204.
25. Scheinman RI, Gualberto A, Jewell CM, Cidlowski JA, Baldwin AS Jr: Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol Cell Biol 1995;15: 943-953.
26. Chrousos GP, Kino T: Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Sci STKE 2005;2005:pe48.
27. Charmandari E, Chrousos GP: Adrenal Insufficiency;in Martini L (ed): Encyclopedia of Endocrine Diseases. San Diego, Elsevier, 2004, pp 75-80.
28. Ferraz-de-Souza B, Achermann JC: Disorders of adrenal development. Endocr Dev 2008;13:19-32.
29. Speiser PW, White PC: Congenital adrenal hyperplasia. N Engl J Med 2003;349: 776-788.
30. Oelkers W: Adrenal insufficiency. N Engl J Med 1996;335: 1206-12.
31. Pizarro CF, Troster EJ, Damiani D, Carcillo JA: Absolute and relative adrenal insufficiency in children with septic shock. Crit Care Med 2005;33: 855-859.
32. Vermes I, Beishuizen A, Hampsink RM, Haanen C: Dissociation of plasma adreno-corticotropin and cortisol levels in critically ill patients: possible role of endothelin and atrial natriuretic hormone. J Clin Endocri-nol Metab 1995;80:1238-1242.
33. Charmandari E, Lichtarowicz-Krynska EJ, Hindmarsh PC, Johnston A, Aynsley-Green A, Brook CG: Congenital adrenal hyperplasia: management during criticalillness. Arch Dis Child 2001;85:26-28.
34. Walker JM, Hughes IA: Tests and normal values in pediatric endocrinology;in Brook CGD (ed): Clinical Pediatric Endocrinology. Oxford, Blackwell, 1996, pp 782-798.
35. Agwu JC, Spoudeas H, Hindmarsh PC, Pringle PJ, Brook CG: Tests of adrenal insufficiency. Arch Dis Child 1999;80:330-333.
36. Gleeson HK, Walker BR, Seckl JR, Padfield PL: Ten years on: safety of short synacthen tests in assessing adrenocorticotropin deficiency in clinical practice. J Clin Endocrinol Metab 2003;88:2106-2111.
37. Lashansky G, Saenger P, Fishman K, Gautier T, Mayes D, Berg G, Di Martino-Nardi J, Reiter E: Normative data for adrenal ste-roidogenesis in a healthy pediatric population: age- and sex-related changes after adrenocorticotropin stimulation. J Clin Endocrinol Metab 1991;73: 674 -686.
38. Barth JH, Seth J, Howlett TA, Freedman DB: A survey of endocrine function testing by clinical biochemistry laboratories in the UK. Ann Clin Biochem 1995;32:442-449.
39. Clark PM, Neylon I, Raggatt PR, Sheppard MC, Stewart PM: Defining the normal cortisol response to the short synacthen test: implications for the investigation of hypothalamic-pituitary disorders. Clin Endocrinol (Oxf ) 1998;49: 287-292.
40. Wallace AM: Analytical support for the detection and treatment of congenital adrenal hyperplasia. Ann Clin Biochem 1995;32:9-27.
41. Rasmuson S, Olsson T, Hagg E: A low-dose ACTH test to assess the function of the hypothalamic-pituitary-adrenal axis. Clin Endocrinol (Oxf ) 1996;44: 151-156.
42. Crowley S, Hindmarsh PC, Holownia P, Honour JW, Brook CGD: The use of low doses of ACTH in the investigation of adrenal function in man. J Endocrinol 1991;130: 475-479.
43. Bridges NA, Hindmarsh PC, Pringle PJ, Honour JW, Brook CGD: Cortisol, andro-stenedione, dehydroepiandrosterone sulphate and 17-hydroxyprogesterone responses to low doses of ACTH(1-24). J Clin Endocrinol Metab 1998;83: 3750 -3753.
44. Newell-Price J, Bertagna X, Grossman AB, Nieman LK: Cushing's syndrome. Lancet 2006;367: 1605-1617.
45. Storr HL, Chan LF, Grossman AB, Savage MO: Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances. Trends Endocrinol Metab 2007;18: 167-174.
46. Batista DL, Riar J, Keil M, Stratakis CA: Diagnostic tests for children who are referred for the investigation of Cushing syndrome. Pediatrics 2007;120:e575-e586.
47. Savage MO, Chan LF, Afshar F, Plowman PN, Grossman AB, Storr HL: Advances in the management of paediatric Cushing's disease. Horm Res 2008;69: 327-333.
48. Perry LA, Grossman AB: The role of the laboratory in the diagnosis of Cushing's syndrome. Ann Clin Biochem 1997;34:345-359.
49. Newell-Price J, Trainer P, Perry L, Wass J, Grossman A, Besser M: A single sleeping midnight cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome. Clin Endocrinol (Oxf) 1995;43:545-550.
50. Papanicolaou DA, Yanovski JA, Cutler GB, Chrousos GP, Nieman LK: A single midnight cortisol measurement distinguishes Cush-ing's syndrome from pseudo-Cushing's states. J Clin Endocrinol Metab 1998;83: 1163-1167.
51. Gorges R, Knappe G, Gerl H, Ventz M, Stahl F: Diagnosis of Cushing's syndrome: re-evaluation of midnight plasma cortisol vs. urinary free cortisol and low-dose dexametha-sone suppression test in a large patient group J Endocrinol Invest 1999;22: 241-249.
52. Reimondo G, Allasino B, Bovio S, Paccotti P, Angeli A, Terzolo M: Evaluation of the effectiveness of midnight serum cortisol in the diagnostic procedures for Cushing's syndrome. Eur J Endocrinol 2005;153:803-809.
53. Martinelli CE, Sader SL, Oliveira EB, Daneluzzi JC, Moreira AC: Salivary cortisol for screening of Cushing's syndrome in children. Clin Endocrinol (Oxf ) 1999;51: 67-71.
54. Raff H, Raff JL, Findling JW: Late-night salivary cortisol as a screening test for Cushing's syndrome. J Clin Endocrinol Metab 1998;83: 2681-2686.
55. Gafni RI, Papanicolaou DA, Nieman LK: Nighttime salivary cortisol measurement as a simple, noninvasive, outpatient screening test for Cushing's syndrome in children and adolescents. J Pediatr 2000;137:30-35.
56. Papanicolaou DA, Mullen N, Kyrou I, Nieman LK: Nighttime salivary cortisol: a useful test for the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 2002;87: 455-4521.
57. Viardot A, Huber P, Puder JJ, Zulewski H, Keller U, Muller B: Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test. J Clin Endocrinol Metab 20 05;90: 5730-5736.
58. Yaneva M, Mosnier-Pudar H, Dugue MA, Grabar S, Fulla Y, Bertagna X: Midnight salivary cortisol for the initial diagnosis of Cushing's syndrome of various causes. J Clin Endocrinol Metab 2004;89: 3345 -3351.
59. Putignano P, Toja P, Dubini A, Giraldi FP, Corsella SM, Cavagnini F: Midnight salivary cortisol versus urinary free and midnight serum cortisol as screening tests for Cushing's sy ndrome. J Clin Endocrinol Metab 2003;88: 4153-4157.
60. Nieman LK, Oldfield EH, Wesley R, Chrousos GP, Loriaux DL, Cutler GB Jr: A simplified morning ovine corticotropin-releasing hormone stimulation test for the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab 1993;77: 1308-1312.
61. Oldfield EH, Doppman JL, Nieman LK, Chrousos GP, Miller DL, Katz DA, Cutler GB Jr, Loriaux DL: Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cush-ing's syndrome. N Engl J Med 1991;325:897-905.
62. Yanovski JA, Cutler GB Jr, Chrousos GP, Nieman LK: The dexamethasone-suppressed corticotropin-releasing hormone stimulation test differentiates mild Cushing's disease from normal physiology. J Clin Endocrinol Metab 1998;83: 348-352.
63. Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM: The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2008;93: 1526-1540.
64. Heuser I, Yassouridis A, Holsboer F: The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J Psychiatr Res 1994;28:341-356.
65. Ising M, Horstmann S, Kloiber S, Lucae S, Binder EB, Kern N, Künzel HE, Pfennig A, Uhr M, Holsboer F: Combined dexametha-sone/corticotropin- releasing hormone test predicts treatment response in major depression - a potential biomarker? Biol Psychiatry 2007;62: 47-54.
66. Chrousos GP: The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995;332: 1351-1362.