The dexamethasone-suppressed corticotropin-releasing hormone stimulation test differentiates mild Cushing's disease from normal physiology

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 2, 1998, Pages 348-352

  Yanovski, Jack A ^a,b,c,d   Cutler Jr , Gordon B ^b,d   Chrousos, George P ^b   Nieman, Lynnette K ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOTROPIN RELEASE; CUSHING SYNDROME; FEMALE; HUMAN; HYPERCORTISOLISM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NEGATIVE FEEDBACK; PRIORITY JOURNAL;

17-HYDROXYCORTICOSTEROIDS; ADRENOCORTICOTROPIC HORMONE; ADULT; CORTICOTROPIN-RELEASING HORMONE; CUSHING SYNDROME; DEXAMETHASONE; FEMALE; HUMANS; HYDROCORTISONE; KINETICS; MALE; MIDDLE AGED;

EID: 0031732662     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.2.348     Document Type: Article

References (25)

1. Liddle G. 1960 Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab. 20:1539-1561.
2. Eddy R, Jones A, Gilliland PF, et al. 1973 Cushing's syndrome: a prospective study of diagnostic methods. Am J Med. 55:621-630.
3. Schteingart D. 1989 Cushing's syndrome. Endocrinol Metab Clin North Am. 18:311-338.
4. Crapo LM. 1979 Cushing's syndrome: a review of diagnostic tests. Metabolism. 28:955-977.
5. Yanovski JA, Cutler Jr GB, Chrousos GP, Nieman LK. 1993 Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration: a new test to distinguish Cushing's syndrome from pseudo-Cushing's states. J Am Med Assoc. 269:2232-2238.
6. Nieman LK, Chrousos GP, Oldfield EH, Avgerinos PC, Cutler Jr G, Loriaux DL. 1986 The ovine corticotropin-releasing hormone stimulation test and the dexamethasone suppression test in the differential diagnosis of Cushing's syndrome. Ann Intern Med. 105:862-867.
7. Gold PW, Loriaux DL, Roy A, et al. 1986 Physiology of hypercortisolism in depression and Cushing's disease. N Engl J Med. 314:1329-1335.
8. Grossman A, Howlett T, Perry L, et al. 1988 CRF in the differential diagnosis of Cushing's syndrome: a comparison with the dexamethasone suppression test. Clin Endocrinol (Oxf). 29:167-178.
9. Rupprecht R, Lesch K, Muller U, et al. 1989 Blunted adrenocorticotropin but normal β-endorphin release after human corticotropin-releasing hormone administration in depression. J Clin Endocrinol Metab. 69:600-603.
10. Bernini GP, Argenio GF, Cerri F, Franchi F. 1994 Comparison between the suppressive effects of dexamethasone and loperamide on cortisol and ACTH secretion in some pathological conditions. J Endocrinol Invest. 17:799-804.
11. Yanovski JA. 1995 The dexamethasone-suppressed CRH test in the differential diagnosis of Cushing disease and pseudo-Cushing states. The Endocrinologist. 5:169-175.
12. Avgerinos PC, Yanovski JA, Oldfield EH, Nieman LK, Cutler Jr G. 1994 The metyrapone and dexamethasone suppression tests tor the differential diagnosis of the adrenocorticotropin-dependent Cushing syndrome: a comparison. Ann Intern Med. 121:318-327.
13. Flack MR, Oldfield EH, Cutler Jr GB, et al. 1992 Urine free cortisol in the high-dose dexamethasone suppression test for the differential diagnosis of the Cushing syndrome. Ann Intern Med. 116:211-217.
14. Nieman LK, Oldfield EH, Wesley R, Chrousos GP, Loriaux DL, Cutler Jr G. 1993 A simplified morning ovine corticotropin-releasing hormone stimulation test for the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab. 77:1308-1312.
15. Findling JW, Doppman JL. Biochemical and radiologic diagnosis of Cushing syndrome. Endocrinol Metab Clin North Am. 23:511-537.
16. Swets JA. 1988 Measuring the accuracy of diagnostic systems. Science. 240:1285-1293.
17. Beck JR, Shultz EK. 1986 The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med. 110:13-20.
18. Dichek HL, Nieman LK, Oldfield EH, Pass HI, Malley JD, Cutler Jr G. 1994 A comparison of the standard high dose dexamethasone suppression test and the overnight 8-mg dexamethasone suppression test for the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab. 78:418-422.
19. Caro JF, Meikle AW, Check JH, Cohen SN. 1978 "Normal Suppression" to dexamethasone in Cushing's disease: an expression of decreased metabolic clearance for dexamethasone. J Clin Endocrinol Metab. 47:667-670.
20. Kapcala LP, Hamilton SM, Meikle AW. 1984 Cushing's disease with 'normal suppression' due to decreased dexamethasone clearance. Arch Intern Med. 144:636-637.
21. Brown RD, Van Loon GR, Orth DN, Liddle GW. 1973 Cushing's disease with periodic hormonogenesis: one explanation for paradoxical response to dexamethasone. J Clin Endocrinol Metab. 36:445-451.
22. Yasuda K. 1996 Cyclic Cushing's disease: pitfalls in the diagnosis and problems with the pathogenesis. Intern Med. 35:169-170.
23. Hermus AR, Pieters GF, Borm GF, et al. 1993 Unpredictable hypersecretion of cortisol in Cushing's disease: detection by daily salivary cortisol measurements. Acta Endocrinol (Copenh). 128:428-432.
24. Stewart PM, Venn P, Heath DA, Holder G. 1992 Cyclical Cushing's syndrome. Br J Hosp Med. 48:186-187.
25. Shapiro MS, Shenkman L. 1991 Variable hormonogenesis in Cushing's syndrome. Q J Med. 79:351-363.