Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 10, 2005, Pages 5730-5736

  Viardot, Alexander ^a,b   Huber, Peter ^a   Puder, Jardena J ^a   Zulewski, Henryk ^a   Keller, Ulrich ^a   Müller, Beat ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; HYDROCORTISONE;

ADULT; AGED; ARTICLE; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION COEFFICIENT; CUSHING SYNDROME; DEXAMETHASONE SUPPRESSION TEST; DIAGNOSTIC PROCEDURE; FEMALE; HUMAN; HYDROCORTISONE URINE LEVEL; HYPERCORTISOLISM; INTERMETHOD COMPARISON; MALE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; REPRODUCIBILITY; SALIVA; SENSITIVITY AND SPECIFICITY; THIRD TRIMESTER PREGNANCY;

ADULT; ANTI-INFLAMMATORY AGENTS; AREA UNDER CURVE; CREATININE; CUSHING SYNDROME; DEXAMETHASONE; FEMALE; HUMANS; HYDROCORTISONE; OBESITY; PREGNANCY; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; ROC CURVE; SALIVA;

EID: 26244460949     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2004-2264     Document Type: Article

References (36)

1. Ross EJ, Linch DC 1982 Cushing's syndrome - killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet 2:646-649
2. Orth DN 1995 Cushing's syndrome. N Engl J Med 332:791-803
3. Gold PW, Loriaux DL, Roy A, Kling MA, Calabrese JR, Kellner CH, Nieman LK, Post RM, Pickar D, Gallucci W, Avgerinos P, Paul S, Oldfield EH, Cutler GB, Chrousos GP 1986 Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease. Pathophysiologic and diagnostic implications. N Engl J Med 314:1329-1335
4. Newell-Price J, Jorgensen JO, Grossman A 1999 The diagnosis and differential diagnosis of Cushing's syndrome. Horm Res 51(Suppl 3):81-94
5. Yanovski JA, Cutler Jr GB, Chrousos GP, Nieman LK 1993 Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states. JAMA 269:2232-2238
6. Bustamante B, Crabbe J 1984 Parotid saliva cortisol in normal subjects: increase during pregnancy. J Steroid Biochem 20:133-136
7. Dorr HG, Heller A, Versmold HT, Sippell WG, Herrmann M, Bidlingmaier F, Knorr D 1989 Longitudinal study of progestins, mineralocorticoids, and glucocorticoids throughout human pregnancy. J Clin Endocrinol Metab 68:863-868
8. Dorn LD, Susman EJ 1993 Serum and saliva cortisol relations in adolescents during pregnancy and the early postpartum period. Biol Psychiatry 34:226-233
9. Meulenberg PM, Hofman JA 1990 Differences between concentrations of salivary cortisol and cortisone and of free cortisol and cortisone in plasma during pregnancy and postpartum. Clin Chem 36:70-75
10. Scott EM, McGarrigle HH, Lachelin GC 1990 The increase in plasma and saliva cortisol levels in pregnancy is not due to the increase in corticosteroid-binding globulin levels. J Clin Endocrinol Metab 71:639-644
11. Findling JW, Raff H, Aron DC 2004 The low-dose dexamethasone suppression test: a reevaluation in patients with Cushing's syndrome. J Clin Endocrinol Metab 89:1222-1226
12. Newell-Price J, Trainer P, Besser M, Grossman A 1998 The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states. Endocr Rev 19:647-672
13. Raff H, Findling JW 2003 A physiologic approach to diagnosis of the Cushing syndrome. Ann Intern Med 138:980-991
14. Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP, Fava GA, Findling JW, Gaillard RC, Grossman AB, Kola B, Lacroix A, Mancini T, Mantero F, Newell-Price J, Nieman LK, Sonino N, Vance ML, Giustina A, Boscaro M 2003 Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 88:5593-5602
15. Murphy BE 2002 Urinary free cortisol determinations: what they measure. Endocrinologist 12:143-150
16. Crapo L 1979 Cushing's syndrome: a review of diagnostic tests. Metabolism 28:955-977
17. Tsigos C, Papanicolaou DA, Chrousos GP 1995 Advances in the diagnosis and treatment of Cushing's syndrome. Baillieres Clin Endocrinol Metab 9:315-336
18. Terzolo M, Borretta G, Ali A, Cesario F, Magro G, Boccuzzi A, Reimondo G, Angeli A 1995 Misdiagnosis of Cushing's syndrome in a patient receiving rifampicin therapy for tuberculosis. Horm Metab Res 27:148-150
19. Krieger DT, Allen W, Rizzo F, Krieger HP 1971 Characterization of the normal temporal pattern of plasma corticosteroid levels. J Clin Endocrinol Metab 32:266-284
20. Newell-Price J, Trainer P, Perry L, Wass J, Grossman A, Besser M 1995 A single sleeping midnight cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome. Clin Endocrinol (Oxf) 43:545-550
21. Papanicolaou DA, Yanovski JA, Cutler Jr GB, Chrousos GP, Nieman LK 1998 A single midnight serum cortisol measurement distinguishes Cushing's syndrome from pseudo-Cushing states. J Clin Endocrinol Metab 83:1163-1167
22. Bolufer P, Gandia A, Rodriguez A, Antonio P 1989 Salivary corticosteroids in the study of adrenal function. Clin Chim Acta 183:217-225
23. Vining RF, McGinley RA 1987 The measurement of hormones in saliva: possibilities and pitfalls. J Steroid Biochem 27:81-94
24. Guechot J, Fiet J, Passa P, Villette JM, Gourmel B, Tabuteau F, Cathelineau G, Dreux C 1982 Physiological and pathological variations in saliva cortisol. Horm Res 16:357-364
25. Riad-Fahmy D, Read GF, Walker RF, Griffiths K 1982 Steroids in saliva for assessing endocrine function. Endocr Rev 3:367-395
26. Read GF, Walker RF, Wilson DW, Griffiths K 1990 Steroid analysis in saliva for the assessment of endocrine function. Ann NY Acad Sci 595:260-274
27. Aardal E, Holm AC 1995 Cortisol in saliva - reference ranges and relation to cortisol in serum. Eur J Clin Chem Clin Biochem 33:927-932
28. Papanicolaou DA, Mullen N, Kyrou I, Nieman LK 2002 Nighttime salivary cortisol: a useful test for the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 87:4515-4521
29. Raff H, Raff JL, Findling JW 1998 Late-night salivary cortisol as a screening test for Cushing's syndrome. J Clin Endocrinol Metab 83:2681-2686
30. Castro M, Elias PC, Quidute AR, Halah FP, Moreira AC 1999 Out-patient screening for Cushing's syndrome: the sensitivity of the combination of circadian rhythm and overnight dexamethasone suppression salivary cortisol tests. J Clin Endocrinol Metab 84:878-882
31. Putignano P, Toja P, Dubini A, Giraldi FP, Corsello SM, Cavagnini F 2003 Midnight salivary cortisol versus urinary free and midnight serum cortisol as screening tests for Cushing's syndrome. J Clin Endocrinol Metab 88:4153-4157
32. Yaneva M, Mosnier-Pudar H, Dugue MA, Grabar S, Fulla Y, Bertagna X 2004 Midnight salivary cortisol for the initial diagnosis of Cushing's syndrome of various causes. J Clin Endocrinol Metab 89:3345-3351
33. Orth DN, Kovacs WJ, De Bold CR 1992 The adrenal cortex. In: Wilson JD, ed. Williams textbook of endocrinology. 8th ed. Philadelphia: WB Saunders; p 581
34. Ockene IS, Matthews CE, Rifai N, Ridker PM, Reed G, Stanek E 2001 Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults. Clin Chem 47:444-450
35. Schoneshofer M, Fenner A, Altinok G, Dulce HJ 1980 Specific and practicable assessment of urinary free cortisol by combination of automatic high-pressure liquid chromatography and radioimmunoassay. Clin Chim Acta 106:63-73
36. Lamb EJ, Noonan KA, Burrin JM 1994 Urine-free cortisol excretion: evidence of sex-dependence. Ann Clin Biochem 31(Pt 5):455-458