Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4594-4600

  Gowda, N R Thimme ^a   Kavitha, C V ^b   Chiruvella, Kishore K ^b   Joy, Omana ^b   Rangappa, Kanchugarakoppal S ^a   Raghavan, Sathees C ^b  

^a UNIVERSITY OF MYSORE   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Anticancer drugs; Apoptosis; Benzimidazole 5 carboxylic acid; Cancer therapeutics; Chemotherapy; DNA damage

Indexed keywords

1 (4 METHOXYPHENETHYL) 1H BENZIMIDAZOLE 5 CARBOXYLIC ACID DERIVATIVE; 1 (4 METHOXYPHENETHYL) 2 (4 FLUORO 3 NITROPHENYL) 1H BENZIMIDAZOLE 5 CARBOXYLATE; ANTILEUKEMIC AGENT; BENZIMIDAZOLE DERIVATIVE; CYCLIN B1; CYCLIN DEPENDENT KINASE 2; CYCLINE; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA STRAND BREAKAGE; DOWN REGULATION; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IC 50; LEUKEMIA; PROTEIN CLEAVAGE; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZIMIDAZOLES; CARBOXYLIC ACIDS; CELL CYCLE; CELL LINE, TUMOR; CYCLIN B; CYCLIN B1; CYCLIN-DEPENDENT KINASE 2; HUMANS; LEUKEMIA; PROLIFERATING CELL NUCLEAR ANTIGEN;

EID: 67651097769     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.103     Document Type: Article

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