Synthesis of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole derivatives as antiproliferative agents: A structure-activity relationship study

Investigational New Drugs

Volumn 27, Issue 6, 2009, Pages 534-542

  Benaka Prasad, S B ^a   Vinaya, K ^a   Ananda Kumar, C S ^a   Swarup, Sanjay ^b   Rangappa, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

2 benzisoxazole; 6 fluoro 3 (4 piperidinyl) 1; Acid chloride; Antiproliferative activity; Cancer therapy; Cell proliferation.; Isonipecotic acid; MTT assay

Indexed keywords

(3 BROMOPHENYL)(4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)METHANONE; (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL) (4 METHYLPIPERAZIN 1 YL)METHANONE; (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)(2 FLUOROPHENYL)METHANONE; (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)(2,4 DICHLORO PHENYL)METHANONE; (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)(2,6 DIFLUOROPHENYL)METHANONE; (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)(3 METHOXYPHENYL)METHANONE; (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)(3,5 DINITRO PHENYL)METHANONE; (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)(MORPHOLINO)METHANONE; (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)(P TOLYL)METHANONE; (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)(PYRROLIDIN 1 YL)METHANONE; (4 CHLOROPHENYL)(4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL)METHANONE; (4 TERT BUTYLPHENYL)(4 (6 FLUOROBENZISOXAZOL 3 YL) PIPERIDIN 1 YL)METHANONE; 1 (4 (6 FLUOROBENZISOXAZOL 3 YL)PIPERIDIN 1 YL) 2 PHENYL ETHANONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 6 FLUORO 3 (4 PIPERIDINYL) 1,2 BENZISOXAZOLE DERIVATIVE; ANTINEOPLASTIC AGENT; AROMATIC CARBOXYLIC ACID; HETEROCYCLIC COMPOUND; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SKIN FIBROBLAST; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTINEOPLASTIC AGENTS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOXAZOLES; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSITION TEMPERATURE;

EID: 70450252406     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-008-9205-5     Document Type: Article

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