Structural and theoretical studies of [6-bromo-1-(4-fluorophenylmethyl)-4(1H)-quinolinon-3-yl)]-4-hydroxy-2-oxo-3-butenoïc acid as HIV-1 integrase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4806-4809

  Vandurm, Pierre ^a   Cauvin, Christine ^a   Guiguen, Allan ^b   Georges, Benoît ^a   Van, Kiet Le ^a   Martinelli, Valérie ^b   Cardona, Christelle ^b   Mbemba, Gladys ^c   Mouscadet, Jean François ^c   Hevesi, László ^a   Lint, Carine Van ^b   Wouters, Johan ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c Ecole Normale Superieure de Cachan   (France)

Author keywords

HIV 1; Integrase inhibitors; Quinolinone; Diketo

Indexed keywords

ETHYL [6 BROMO 1 (4 FLUOROPHENYLMETHYL) 4(1H) QUINOLINON 3 YL] 4 HYDROXY 2 OXO 3 BUTENOATE; INTEGRASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; [6 BROMO 1 (4 FLUOROPHENYLMETHYL) 4(1H) QUINOLINON 3 YL] 4 HYDROXY 2 OXO 3 BUTENOIC ACID;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DOCKING; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

4-QUINOLONES; BUTYRIC ACIDS; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HUMANS; MOLECULAR CONFORMATION; PROTEIN BINDING; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67651091690     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.044     Document Type: Article

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