The agent of human granulocytic ehrlichiosis resides in an endosomal compartment

Journal of Clinical Investigation

Volumn 101, Issue 9, 1998, Pages 1932-1941

  Webster, Paul ^a   IJdo, Jacob W ^a   Chicoine, Linda M ^a   Fikrig, Erol ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibody; Ehrlichia; Endosome; Intracellular pathogen; Neutrophil

Indexed keywords

ARTICLE; EHRLICHIA; EHRLICHIOSIS; ENDOSOME; GRANULOCYTE; HOST CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0032080403     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1544     Document Type: Article

References (46)

1. Bakken, J.S., J.S. Dumler, S.M. Chen, M.R. Eckman, L.L. Van Etta, and D.H. Walker. 1994. Human granulocytic ehrlichiosis in the upper midwest United States. A new species emerging? JAMA (J. Am. Med. Assoc.). 272:212-218.
2. Chen, S.M., J.S. Dumler, J.S. Bakken, and D.H. Walker. 1994. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J. Clin. Microbiol. 32:589-595.
3. Dawson, J.E., B.E. Anderson, D.B. Fishbein, J.L. Sanchez, C.S. Goldsmith, K.H. Wilson, and C.W. Duntley. 1991. Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis. J. Clin. Microbiol. 29:2741-2745.
4. Dumler, J.S., K.M. Asanovich, J.S. Bakken, P. Richter, R. Kimsey, and J.E. Madigan. 1995. Serologic cross-reactions among Ehrlichia equi, Ehrlichia phagocytophila, and human granulocytic ehrlichia. J. Clin. Microbiol. 33:1098-1103.
5. Johansson, K.E., B. Pettersson, M. Uhlen, A. Gunnarsson, M. Malmqvist, and E. Olsson. 1995. Identification of the causative agent of granulocytic ehrlichiosis in Swedish dogs and horses by direct solid phase sequencing of PCR products from the 16S rRNA gene. Res. Vet. Sci. 58:109-112.
6. Magnarelli, L.A., J.S. Dumler, J.F. Anderson, R.C. Johnson, and E. Fikrig. 1995. Coexistence of antibodies to tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in human sera. J. Clin. Microbiol. 33:3054-3057.
7. Pierard, D., E. Levtchenko, J.E. Dawson, and S. Lauwers. 1995. Ehrlichiosis in Belgium. Lancet. 346:1233-1234.
8. Brouqui, P., J.S. Dumler, R. Lienhard, M. Brossard, and D. Raoult. 1995. Human granulocytic ehrlichiosis in Europe. Lancet. 346:782-783.
9. Reed, K.D., P.D. Mitchell, D.H. Persing, C.P. Kolbert, and V. Cameron. 1995. Transmission of human granulocytic ehrlichiosis. JAMA. (J. Am. Med. Assoc.). 273:23.
10. Goodman, J.L., C. Nelson, B. Vitale, J.E. Madigan, J.S. Dumler, T.J. Kurtti, and U.G. Munderloh. 1996. Direct cultivation of the causative agent of human granulocytic ehrlichiosis. N. Engl. J. Med. 334:209-215.
11. Theriot, J.A. 1995. The cell biology of infection by intracellular bacterial pathogens. Cell. Dev. Biol. 11:213-239.
12. Winkler, H.H. 1990. Rickettsia species (as organisms). Annu. Rev. Microbiol. 44:131-153.
13. Rabinovitch, M., and P.S. Veras. 1996. Cohabitation of Leishmania amazonensis and Coxiella burnetii. Trends Microbiol. 4:158-161.
14. Sturgill-Koszycki, S., P.H. Schlesinger, P. Chakraborty, P.L. Haddix, H.L. Collins, A.K. Fok, R.D. Allen, S.L. Gluck, J. Heuser, and D.G. Russell. 1994. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science. 263:678-681.
15. Desjardins, M., L.A. Huber, R.G. Parton, and G. Griffiths. 1994. Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus. J. Cell Biol. 124:677-688.
16. Sinai, A.P., and K.A. Joiner. 1997. Safe haven: the cell biology of nonfusogenic pathogen vacuoles. Annu. Rev. Microbiol. 51:415-462.
17. Clemens, D.L., and M.A. Horwitz. 1995. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J. Exp. Med. 181:257-270.
18. Joiner, K.A., S.A. Fuhrman, H.M. Miettinen, L.H. Kasper, and I. Mellman. 1990. Toxoplasma gondii: fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts. Science. 249:641-646.
19. Hackstadt, T., D.D. Rockey, R.A. Heinzen, and M.A. Scidmore. 1996. Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane. EMBO (Eur. Mol. Biol. Organ.) J. 15:964-977.
20. Scidmore, M.A., E.R. Fischer, and T. Hackstadt. 1996. Sphingolipids and glycoproteins are differentially trafficked to the Chlamydia trachomatis inclusion. J. Cell Biol. 134:363-374.
21. Andrews, N.W., C.K. Abrams, S.L. Slatin, and G. Griffiths. 1990. A T. cruzi-secreted protein immunologically related to the complement component C9: evidence for membrane pore-forming activity at low pH. Cell. 61:1277-1287.
22. Popov, V.L., S.M. Chen, H.M. Feng, and D.H. Walker. 1995. Ultrastructural variation of cultured Ehrlichia chaffeensis. J. Med. Microbiol. 43:411-421.
23. Kocan, K.M., D. Stiller, W.L. Goff, P.L. Claypool, W. Edwards, S.A. Ewing, T.C. McGuire, J.A. Hair, and S.J. Barron. 1992. Development of Anaplasma marginale in male Dermacentor andersoni transferred from parasitemic to susceptible cattle. Am. J. Vet. Res. 53:499-507.
24. Wells, M.Y., and Y. Rikihisa. 1988. Lack of lysosomal fusion with phagosomes containing Ehrlichia risticii in P388D1 cells: abrogation of inhibition with oxytetracycline. Infect. Immun. 56:3209-3215.
25. Barnewall, R.E., Y. Rikihisa, and E.H. Lee. 1997. Ehrlichia chaffeensis inclusions are early endosomes which selectively accumulate transferrin receptor. Infect. Immun. 65:1455-1461.
26. Telford, S.R., III, J.E. Dawson, P. Katavolos, C.K. Warner, C.P. Kolbert, and D.H. Pershing. 1996. Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proc. Natl. Acad. Sci. USA. 93:6209-6214.
27. Hanson, B.A., C.L. Wisseman, A. Waddell, and D.J. Silverman. 1981. Some characteristics of heavy and light bands of Rickettsia prowazekii on renografin gradients. Infect. Immun. 34:596-604.
28. Chen, S.M., J.S. Dumler, H.M. Feng, and D.H. Walker. 1994. Identification of the antigenic constituents of Ehrlichia chaffeensis. Am. J. Trop. Med. Hyg. 50:52-58.
29. Sun, W., J.W. IJdo, S.R. Telford III, E. Hodzic, Y. Zhang, S.W. Barthold, and E. Fikrig. 1997. Immunization against the agent of Human Granulocytic Ehrlichiosis in a murine model. J. Clin. Invest. 100:3014-3018.
30. Slot, J.W., and H.J. Geuze. 1981. Sizing of protein A-colloidal gold probes for immunoelectron microscopy. J. Cell Biol. 90:533-536.
31. Slot, J.W., and H.J. Geuze. 1985. A new method of preparing gold probes for multiple-labeling cytochemistry. Eur. J. Cell. Biol. 38:87-93.
32. Griffiths, G. 1993. Fine Structure Immunocytochemistry. Springer Verlag, Berlin, 275 pp.
33. Liou, W., H.J. Geuze, and J.W. Slot. 1996. Improving structural integrity of cryosections for immunogold labeling. Histochern. Cell Biol. 106:41-58.
34. Anderson, R.G., J.R. Falck, J.L. Goldstein, and M.S. Brown. 1984. Visualization of acidic organelles in intact cells by electron microscopy. Proc. Natl. Acad. Sci. USA. 81:4838-4842.
35. Mayhew, T.M., and H.J. Gundersen. 1996. If you assume, you can make an ass out of u and me: a decade of the disector for stereological counting of particles in 3D space. J. Anat. 188:1-15.
36. Weibel, E. 1979. Practical Methods for Biological Morphometry. Stereological Methods. Vol. 1. Academic Press, New York. 193 pp.
37. Scidmore, M.A., D.D. Rockey, E.R. Fischer, R.A. Heinzen, and T. Hackstadt. 1996. Vesicular interactions of the Chlamydia trachomatis inclusion are determined by chlamydial early protein synthesis rather than route of entry. Infect. Immun. 64:5366-5377.
38. Heinzen, R.A., M.A. Scidmore, D.D. Rockey, and T. Hackstadt. 1996. Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis. Infect. Immun. 64:796-809.
39. Taraska, T., D.M. Ward, R.S. Ajioka, P.B. Wyrick, S.R. Davis-Kaplan, C.H. Davis, and J. Kaplan. 1996. The late chlamydial inclusion membrane is not derived from the endocytic pathway and is relatively deficient in host proteins. Infect. Immun. 64:3713-3727.
40. Hackstadt, T., M.A. Scidmore, and D.D. Rockey. 1995. Lipid metabolism in Chlamydia trachomatis-infected cells: directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion. Proc. Natl. Acad. Sci. USA. 92:4877-4881.
41. Ristic, M. 1968. Anaplasmosis. In Infectious Blood Diseases of Man and Animals. D. Weinman and M. Ristic, editors. Academic Press, Inc., New York. 478-572.
42. Weisburg, W.O., S.M. Barns, D.A. Pelletier, and D.J. Lane. 1991. 16S ribosomal DNA amplification for phylogenetic study. J. Bacteriol. 173:697-703.
43. McGarey, D.J., A.F. Barbet, G.H. Palmer, T.C. McGuire, and D.R. Allred. 1994. Putative adhesins of Anaplasma marginale: major surface polypeptides 1a and 1b. Infect. Immun. 62:4594-4601.
44. Zhang, J.P., and R.S. Stephens. 1992. Mechanism of Chlamydia trachomatis attachment to eukaryotic host cells. Cell. 69:861-869.
45. Pitt, A., L.S. Mayorga, P.D. Stahl, and A.L. Schwartz. 1992. Alterations in the protein composition of maturing phagosomes. J. Clin. Invest. 90:1978-1983.
46. Pitt, A., L.S. Mayorga, A.L. Schwart, and P.D. Stahl. 1992. Transport of phagosomal components to an endosomal compartment. J. Biol. Chem. 267: 126-132.