Hemostatic changes in dogs with naturally occurring sepsis

Journal of Veterinary Internal Medicine

Volumn 17, Issue 5, 2003, Pages 674-679

  De Laforcade, Armelle M ^a   Freeman, Lisa M ^a   Shaw, Scott P ^a   Brooks, Marjory B ^b   Rozanski, Elizabeth A ^a   Rush, John E ^a  

^a TUFTS UNIVERSITY   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Antithrombin; Dogs; Hemostasis; Infection; Protein C

Indexed keywords

ARTICLE; CONTROLLED STUDY; HEMOSTASIS; HISTOLOGY; HYPERTHERMIA; HYPOTHERMIA; LEUKOPENIA; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PROTEIN DEGRADATION; PROTHROMBIN TIME; SAMPLING; SEPSIS; TACHYCARDIA; TACHYPNEA; THROMBOCYTE COUNT;

ANIMALS; ANTITHROMBIN III; CASE-CONTROL STUDIES; DOG DISEASES; DOGS; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; INTENSIVE CARE; MALE; PARTIAL THROMBOPLASTIN TIME; PLATELET COUNT; PROTEIN C; PROTHROMBIN TIME; SEPSIS; SHOCK, SEPTIC;

ANIMALIA; CANIS FAMILIARIS;

EID: 0141993042     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1892/0891-6640(2003)017<0674:HCIDWN>2.3.CO;2     Document Type: Article

References (40)

1. O'Reilly MO, Newcomb DE, Remick D. Endotoxin, sepsis, and the primrose path. Shock 1999;12:411-420.
2. Bone RC. Gram-negative sepsis: A dilemma of modern medicine. Clin Microbiol Rev 1993;6:57-68.
3. Rangel-Frausto MS, Pittet D, Costigan M, et al. The natural history of the systemic inflammatory response syndrome (SIRS): A prospective study. JAMA 1995;273:117-23.
4. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med 1999;340:207-214.
5. Hardie EM. Life-threatening bacterial infection. Comp Cont Ed 1995;17:763-777.
6. Hosgood G, Salisbury SK. Generalized peritonitis in dogs: 50 cases. J Am Vet Med Assoc 1988;193:1448-1450.
7. Greenfield CL, Walshaw R. Open peritoneal drainage in the treatment of contaminated peritoneal cavity and septic peritonitis in dogs and cats: 24 cases (1980-1986). J Am Vet Med Assoc 1987;191:100-105.
8. Woolfson JM, Dulish ML. Open abdominal drainage in the treatment of generalized peritonitis in 25 dogs and cats. Vet Surg 1986;15: 27-32.
9. Fourrier F, Chopin C, Goudemand J, et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation: Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest 1992;101:816-823.
10. Mammen EF. Antithrombin III and sepsis. Intensive Care Med 1998;24:649-650.
11. Esmon CT, Taylor FB, Snow TR. Inflammation and coagulation: Linked processes potentially regulated through a common pathway mediated by protein C. Thromb Haemost 1991;66:160-165.
12. Esmon CT, Fukudome K, Mather T, et al. Inflammation, sepsis, and coagulation. Haematologica 1999;84:254-259.
13. Thijs LG, de Boer JP, de Groot M, et al. Coagulation disorders in septic shock. Intensive Care Med 1993;19(Suppl 1):S-S15.
14. Levi M, de Jonge E, van der Poll, et al. Novel approaches to the management of disseminated intravascular coagulation. Crit Care Med 2000;28:S20-S24.
15. Boldt J, Papsdorf M, Rothe A, et al. Changes of the hemostatic network in critically ill patients - Is there a difference between sepsis, trauma, and neurosurgery patients? Crit Care Med 2000;28:445-450.
16. Lorente JA, Gardia-Frade LJ, Landin L, et al. Time course of hemostatic abnormalities in sepsis and its relation to outcome. Chest 1993;103:1536-1542.
17. Hesselvik JF, Blomback M, Broden B, et al. Coagulation, fibrinolysis, and kallikrein systems in sepsis: Relation to outcome. Crit Care Med 1989;17:724-733.
18. Mesters RM, Mannucci PM, Coppola R, et al. Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients. Blood 1996;88:881-886.
19. Mesters RM, Helterbrand J, Utterback BG. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications. Crit Care Med 2000;28:2209-2216.
20. Hesselvik JF, Malm J, Dahlback B. Protein C, protein S and C4b-binding protein in severe infection and septic shock. Thromb Haemost 1991;65:126-129.
21. Aronis S, Hatzis A, Platokouki H, et al. Severe protein C deficiency, predictor of lethal outcome in meningococcal septicemia. Pediatr Res 1999;45: 765 (Abstr 132).
22. Yan SB, Helterbrand JD, Hartman DL, et al. Low levels of protein C are associated with poor outcome in severe sepsis. Chest 2001;120:915-922.
23. Alcaraz A, Espana F, Sanchesz-Cuenca, et al. Activation of the protein C pathway in acute sepsis. Thromb Res 1995;79:83-93.
24. Wilson RF, Mammen EF, Tyburski JG, et al. Antithrombin levels related to infections and outcome. J Trauma 1996;40:384-387.
25. Madden RM, Ward M, Marlar RA. Protein C activity levels in endotoxin-induced disseminated intravascular coagulation in a dog model. Thromb Res 1989;55:297-307.
26. Fisher CJ, Yan SB. Protein C levels as a prognostic indicator of outcome in sepsis and related diseases. Crit Care Med 2000; 28(Suppl):S49-S55.
27. Bernard GR, Vincent JL, Laterre PF. Efficacy and safety of recombinant human activated protein C for severe sepsis. New Engl J Med 2001;344:699-709.
28. Feldman BF, Madewell BR, O'Neill S. Disseminated intravascular coagulation: Antithrombin, plasminogen, and coagulation abnormalities in 41 dogs. J Am Vet Med Assoc 1981;179:151-154.
29. Ritt MG, Rogers KS, Thomas JS. Nephrotic syndrome resulting in thromboembolic disease and disseminated intravascular coagulation in a dog. J Am Anim Hosp Assoc 1997;33:385-391.
30. Otto CM, Rieser TM, Brooks MB, et al. Evidence of hypercoagulability in dogs with parvoviral enteritis. J Am Vet Med Assoc 2000;217:1500-1504.
31. Barton MH, Morris DD, Norton N, et al. Hemostatic and fibronolytic indices in neonatal foals with presumed septicemia. J Vet Intern Med 1998;12:26-35.
32. Hauptman JG, Walshaw R, Olivier NB. Evaluation of the sensitivity and specificity of diagnostic criteria for sepsis in dogs. Vet Surg 1997;26:393-397.
33. Stokol T, Brooks MB, Erb HN, et al. D-dimer concentrations in healthy dogs and dogs with disseminated intravascular coagulation. Am J Vet Res 2000;61:393-398.
34. Dang QD, Di Cera E. Chromogenic substrates selective for activated protein C. Blood 1997;89:2220-2221.
35. Scott-Moncrieff JC, Treadwell NG, McCullough SM, Brooks MB. Hemostatic abnormalities in dogs with primary immune mediated hemolytic anemia. J Am Anim Hosp Assoc 2001;37:220-227.
36. Stokol T, Brooks M, Erb H, et al. Evaluation of kits for the detection of fibrin(ogen) degradation products in dogs. J Vet Intern Med 1999;13:478-484.
37. Green RA. Pathophysiology of antithrombin deficiency. Vet Clin N Am 1988;18:95-103.
38. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20:864-874.
39. Vincent JL, de Mendonca A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study. Crit Care Med 1998;26:1793-1800.
40. Sugarman HG, Austin G, Newsome R, et al. Hemodynamics, oxygen consumption and serum catecholamine changes in progressive lethal peritonitis in the dog. Surg Gynecol Obstet 1982;154:8-12.