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59649084514
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Irreversible intestinal failure: Prevalence and prognostic factors
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In this series of patients with intestinal failure, survival rate was significantly higher in SBS patients than in the other groups (P < 0.01). SBS patients showed a higher rate of major complications, though only IFALD was significantly higher (P < 0.001)
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Diamanti A, Basso MS, Castro M, et al. Irreversible intestinal failure: prevalence and prognostic factors. J Pediatr Gastroenterol Nutr 2008; 47:450-457. In this series of patients with intestinal failure, survival rate was significantly higher in SBS patients than in the other groups (P < 0.01). SBS patients showed a higher rate of major complications, though only IFALD was significantly higher (P < 0.001).
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(2008)
J Pediatr Gastroenterol Nutr
, vol.47
, pp. 450-457
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Diamanti, A.1
Basso, M.S.2
Castro, M.3
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52
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60149112231
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An evaluation of model for endstage liver disease and serum C-reactive protein as prognostic markers in intestinal failure patients on PN
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The authors evaluated for the first time the use of the model for end-stage liver disease (MELD) and serum C-reactive protein (CRP) as predictive markers of mortality in intestinal failure patients. Both seem to be promising clinical tools to identify which patients are at highest risk for complication
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Putchakayala K, Polensky S, Fitzhugh J, et al. An evaluation of model for endstage liver disease and serum C-reactive protein as prognostic markers in intestinal failure patients on PN. J Parenter Enteral Nutr 2009; 33:55-61. The authors evaluated for the first time the use of the model for end-stage liver disease (MELD) and serum C-reactive protein (CRP) as predictive markers of mortality in intestinal failure patients. Both seem to be promising clinical tools to identify which patients are at highest risk for complication.
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(2009)
J Parenter Enteral Nutr
, vol.33
, pp. 55-61
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Putchakayala, K.1
Polensky, S.2
Fitzhugh, J.3
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53
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43449092568
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Factors affecting survival to intestinal transplantation in the very young pediatric patient
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In children younger than 18 months, risk factors affecting survival to intestinal transplantation include small body size and advanced liver disease. A primary diagnosis of intestinal atresia and the presence of the ileocecal valve may confer additional risk to these very young children
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Mian SI, Dutta S, Le B, et al. Factors affecting survival to intestinal transplantation in the very young pediatric patient. Transplantation 2008; 85:1287-1289. In children younger than 18 months, risk factors affecting survival to intestinal transplantation include small body size and advanced liver disease. A primary diagnosis of intestinal atresia and the presence of the ileocecal valve may confer additional risk to these very young children.
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(2008)
Transplantation
, vol.85
, pp. 1287-1289
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Mian, S.I.1
Dutta, S.2
Le, B.3
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54
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46049089136
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Survival of patients identified as candidates for intestinal transplantation: A 3-year prospective follow-up
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Home Artificial Nutrition Working Group of the European Society for Clinical Nutrition and Metabolism (ESPEN) Collaborators
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Pironi L, Forbes A, Joly F, et al., Home Artificial Nutrition Working Group of the European Society for Clinical Nutrition and Metabolism (ESPEN) Collaborators. Survival of patients identified as candidates for intestinal transplantation: a 3-year prospective follow-up. Gastroenterology 2008; 135:61-71.
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(2008)
Gastroenterology
, vol.135
, pp. 61-71
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Pironi, L.1
Forbes, A.2
Joly, F.3
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55
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15444379062
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Intestine Transplant Registry. 2003 report of the intestine transplant registry: A new era has dawned
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Grant D, Abu-Elmagd K, Reyes J, et al., Intestine Transplant Registry. 2003 report of the intestine transplant registry: a new era has dawned. Ann Surg 2005; 241:607-613.
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(2005)
Ann Surg
, vol.241
, pp. 607-613
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Grant, D.1
Abu-Elmagd, K.2
Reyes, J.3
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56
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41149107357
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Long-term outcome, growth and digestive function in children 2 to 18 years after intestinal transplantation
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This series of 31 children indicates that long-term intestinal autonomy for up to 18 years is possible in the majority of patients after intestinal Tx. Subnormal energy absorption and moderate steatorrhea were often compensated for by hyperphagia, allowing normal growth and attainment of adult height. Long-term compliance is an important prerequisite for long-term graft function
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Lacaille F, Vass N, Sauvat F, et al. Long-term outcome, growth and digestive function in children 2 to 18 years after intestinal transplantation. Gut 2008; 57:455-461. This series of 31 children indicates that long-term intestinal autonomy for up to 18 years is possible in the majority of patients after intestinal Tx. Subnormal energy absorption and moderate steatorrhea were often compensated for by hyperphagia, allowing normal growth and attainment of adult height. Long-term compliance is an important prerequisite for long-term graft function.
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(2008)
Gut
, vol.57
, pp. 455-461
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Lacaille, F.1
Vass, N.2
Sauvat, F.3
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57
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33745974576
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Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndrome
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DOI 10.1002/lt.20763
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Botha JF, Grant WJ, Torres C, et al. Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndrome. Liver Transpl 2006; 12:1062-1066. (Pubitemid 44063779)
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(2006)
Liver Transplantation
, vol.12
, Issue.7
, pp. 1062-1066
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Botha, J.F.1
Grant, W.J.2
Torres, C.3
Iverson, A.K.4
Sudan, D.L.5
Shaw Jr., B.W.6
Langnas, A.N.7
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58
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51749104615
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The impact of longitudinal intestinal lengthening and tailoring (LILT) on liver function in short bowel syndrome
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The authors reported a cohort of 55 patients with SBS managed with LILT. After LILT, all patients with liver fibrosis who could be weaned from parenteral nutrition showed a normalization of liver enzymes. They consider that preoperative liver biopsy is mandatory in order to differentiate reversible liver fibrosis from end-stage liver disease
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Reinshagen K, Zahn K, Buch C, et al. The impact of longitudinal intestinal lengthening and tailoring (LILT) on liver function in short bowel syndrome. Eur J Pediatr Surg 2008; 18:249-253. The authors reported a cohort of 55 patients with SBS managed with LILT. After LILT, all patients with liver fibrosis who could be weaned from parenteral nutrition showed a normalization of liver enzymes. They consider that preoperative liver biopsy is mandatory in order to differentiate reversible liver fibrosis from end-stage liver disease.
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(2008)
Eur J Pediatr Surg
, vol.18
, pp. 249-253
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Reinshagen, K.1
Zahn, K.2
Buch, C.3
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59
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33847123937
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First report of the international serial transverse enteroplasty data registry: Indications, efficacy, and complications
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International STEP Data Registry. This is the first report of the International STEP Data Registry including the first 38 patients in 19 centers from three countries. Median follow-up was of 12.6 months (range 0-66.9 months). Mean small intestine length was substantially increased (68 ± 44 cm versus 115 ± 87 cm, P < 0.0001, n = 27). Late outcomes included progression to transplantation (n = 3) and mortality (n = 3). For the SBS cohort, enteral tolerance was notably increased from 31 ± 31% to 67 ± 37% of calories (P < 0.01, n = 21)
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Modi BP, Javid PJ, Jaksic T, et al., International STEP Data Registry. First report of the international serial transverse enteroplasty data registry: indications, efficacy, and complications. J Am Coll Surg 2007; 204:365-367. This is the first report of the International STEP Data Registry including the first 38 patients in 19 centers from three countries. Median follow-up was of 12.6 months (range 0-66.9 months). Mean small intestine length was substantially increased (68 ± 44 cm versus 115 ± 87 cm, P < 0.0001, n = 27). Late outcomes included progression to transplantation (n = 3) and mortality (n = 3). For the SBS cohort, enteral tolerance was notably increased from 31 ± 31% to 67 ± 37% of calories (P < 0.01, n = 21).
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(2007)
J Am Coll Surg
, vol.204
, pp. 365-367
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Modi, B.P.1
Javid, P.J.2
Jaksic, T.3
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60
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43449093153
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Repeat surgical bowel lengthening with the STEP procedure
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DOI 10.1097/TP.0b013e31817268ca, PII 0000789020080515000014
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Andres AM, Thompson J, Grant W, et al. Repeat surgical bowel lengthening with the STEP procedure. Transplantation 2008; 85:1294-1299. Repeat lengthening with STEP was performed 16 times in 14 patients leading to discontinuation of TPN in almost half of these carefully selected patients and does not preclude intestinal transplantation. (Pubitemid 351670480)
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(2008)
Transplantation
, vol.85
, Issue.9
, pp. 1294-1299
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Andres, A.M.1
Thompson, J.2
Grant, W.3
Botha, J.4
Sunderman, B.5
Antonson, D.6
Langnas, A.7
Sudan, D.8
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61
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47949114969
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Regression of hepatic fibrosis after intestinal transplantation in total parenteral nutrition liver disease
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From four patients who underwent isolated intestinal transplantation having significant liver fibrosis, the authors consider that significant hepatic fibrosis and liver dysfunction may regress after intestinal transplantation and fibrosis regresses more rapidly in portal areas. This suggests that some patients with IFALD may safely undergo isolated intestinal transplant without the need for concurrent liver transplantation and its attendant higher morbidity and mortality
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Fiel MI, Sauter B, Wu HS, et al. Regression of hepatic fibrosis after intestinal transplantation in total parenteral nutrition liver disease. Clin Gastroenterol Hepatol 2008; 6:926-933. From four patients who underwent isolated intestinal transplantation having significant liver fibrosis, the authors consider that significant hepatic fibrosis and liver dysfunction may regress after intestinal transplantation and fibrosis regresses more rapidly in portal areas. This suggests that some patients with IFALD may safely undergo isolated intestinal transplant without the need for concurrent liver transplantation and its attendant higher morbidity and mortality.
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(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 926-933
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Fiel, M.I.1
Sauter, B.2
Wu, H.S.3
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62
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55549091429
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Neonatal onset intestinal failure: An Italian Multicenter Study
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Working Group on Neonatal Gastroenterology of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition.
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Salvia G, Guarino A, Terrin G, et al., Working Group on Neonatal Gastroenterology of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition. Neonatal onset intestinal failure: an Italian Multicenter Study. J Pediatr 2008; 153:674-676.
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(2008)
J Pediatr
, vol.153
, pp. 674-676
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Salvia, G.1
Guarino, A.2
Terrin, G.3
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63
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39849084782
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Chronic biochemical cholestasis in patients receiving home parenteral nutrition: Prevalence and predisposing factors
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This study shows that chronic biochemical cholestasis is common in patients receiving home parenteral nutrition. By multivariate analysis, it shows that high parenteral calorie intake and lack of a colon in continuity with small intestine are independently associated with an increased risk of chronic biochemical cholestasis
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Lloyd DA, Zabron AA, Gabe SM. Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors. Aliment Pharmacol Ther 2008; 27:552-560. This study shows that chronic biochemical cholestasis is common in patients receiving home parenteral nutrition. By multivariate analysis, it shows that high parenteral calorie intake and lack of a colon in continuity with small intestine are independently associated with an increased risk of chronic biochemical cholestasis.
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(2008)
Aliment Pharmacol Ther
, vol.27
, pp. 552-560
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Lloyd, D.A.1
Zabron, A.A.2
Gabe, S.M.3
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64
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36549035270
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The optimal timing of intestinal transplantation for children with intestinal failure: A Markov analysis
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A Markov analytic model was used to determine life expectancy and quality-adjusted life years on a theoretical cohort of 4-year-old patients for two treatment strategies: standard care consisting of parenteral nutrition and referral to transplantation according to accepted guidelines and early listing for isolated small intestine transplantation. Children with SBS dependent on parenteral nutrition should be considered for intestinal transplantation earlier than what is current practice
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Lopushinsky SR, Fowler RA, Kulkarni GS, et al. The optimal timing of intestinal transplantation for children with intestinal failure: a Markov analysis. Ann Surg 2007; 246:1092-1099. A Markov analytic model was used to determine life expectancy and quality-adjusted life years on a theoretical cohort of 4-year-old patients for two treatment strategies: standard care consisting of parenteral nutrition and referral to transplantation according to accepted guidelines and early listing for isolated small intestine transplantation. Children with SBS dependent on parenteral nutrition should be considered for intestinal transplantation earlier than what is current practice.
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(2007)
Ann Surg
, vol.246
, pp. 1092-1099
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Lopushinsky, S.R.1
Fowler, R.A.2
Kulkarni, G.S.3
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65
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33846874750
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Sources of the very-long-chain unsaturated omega-3 fatty acids: Eicosapentaenoic acid and docosahexaenoic acid
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Racine RA, Deckelbaum RJ. Sources of the very-long-chain unsaturated omega-3 fatty acids: eicosapentaenoic acid and docosahexaenoic acid. Curr Opin Clin Nutr Metab Care 2007; 10:123-128.
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(2007)
Curr Opin Clin Nutr Metab Care
, vol.10
, pp. 123-128
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Racine, R.A.1
Deckelbaum, R.J.2
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