Resveratrol-induced Apoptosis in Human Breast Cancer Cells Is Mediated Primarily through the Caspase-3-dependent Pathway

Archives of Medical Research

Volumn 39, Issue 2, 2008, Pages 162-168

  Alkhalaf, Moussa ^a   El Mowafy, Abdulla ^b   Renno, Waleed ^a   Rachid, Ousama ^a   Ali, Ahmed ^a   Al Attyiah, Rajaa ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RESVERATROL;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER PREVENTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; WESTERN BLOTTING;

ANTIOXIDANTS; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; FEMALE; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; STILBENES;

EID: 37349014774     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2007.09.003     Document Type: Article

References (36)

1. Gehm B.D., McAndrews J.M., Chien P.Y., and Jameson J.L. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci USA 94 (1997) 14138-14143
2. Jang M., Cai L., Udeani G.O., Slowing K.V., Thomas C.F., Beecher C.W., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 (1997) 218-220
3. Baur J.A., and Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5 (2006) 493-506
4. Delmas D., Lancon A., Colin D., Jannin B., and Latruffe N. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets 7 (2006) 423-442
5. Renaud S., and de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339 (1992) 1523-1526
6. Pervaiz S. Chemotherapeutic potential of the chemopreventive phytoalexin resveratrol. Drug Resist Update 7 (2004) 333-344
7. Clement M.V., Hirpara J.L., Chawdhury S.H., and Pervaiz S. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signalingdependent apoptosis in human tumor cells. Blood 92 (1998) 996-1002
8. Hsieh T.C., and Wu J.M. Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines. Exp Cell Res 249 (1999) 109-115
9. Schneider Y., Duranton B., Gosse F., Schleiffer R., Seiler N., and Raul F. Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis. Nutr Cancer 39 (2001) 102-107
10. Scarlatti F., Sala G., Somenzi G., Signorelli P., Sacchi N., and Ghidoni R. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J 17 (2003) 2339-2341
11. El-Mowafy A.M., and Alkhalaf M. Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. Carcinogenesis 24 (2003) 869-873
12. Alkhalaf M., and Jaffal S. Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: novel cellular mechanisms involving ERKs/p53 cascade. Free Radic Biol Med 41 (2006) 318-325
13. Alkhalaf M. Resveratrol-induced growth inhibition in MDA-MB-231 breast cancer cells is associated with MAPK signaling and protein translation. Eur J Cancer Prev 16 (2007) 334-341
14. Tessitore L., Davit A., Sarotto I., and Caderni G. Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. Carcinogenesis 21 (2000) 1619-1622
15. Bhat K.P., Lantvit D., Christov K., Mehta R.G., Moon R.C., and Pezzuto J.M. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 61 (2001) 7456-7463
16. Banerjee S., Bueso-Ramos C., and Aggarwal B.B. Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 62 (2002) 4945-4954
17. Oliver F.J., de la Rubia G., Rolli V., Ruiz-Ruiz M.C., de Murcia G., and Murcia J.M. Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant. J Biol Chem 273 (1998) 33533-33539
18. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., and Earnshaw W.C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371 (1994) 346-347
19. Nicholson D.W., Ali A., Thornberry N.A., Vaillancourt J.P., Ding C.K., Gallant M., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376 (1995) 37-43
20. Chen L., Smith L., Wang Z., and Smith J.B. Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination. Mol Pharmacol 64 (2003) 334-345
21. Phelps M., Darley M., Primrose J.N., and Blaydes J.P. p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. Cancer Res 63 (2003) 2616-2623
22. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
23. Signorelli P., and Ghidoni R. Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutr Biochem 16 (2005) 449-466
24. Holmes-McNary M., and Baldwin Jr. A.S. Chemopreventive properties of transresveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Res 60 (2000) 3477-3483
25. Bernhard D., Tinhofer I., Tonko M., Hubl H., Ausserlechner M.J., Greil R., et al. Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells. Cell Death Differ 7 (2000) 834-842
26. Tinhofer I., Bernhard D., Senfter M., Anether G., Loeffler M., Kroemer G., et al. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. FASEB J 15 (2001) 1613-1615
27. Opipari Jr. A.W., Tan L., Boitano A.E., Sorenson D.R., Aurora A., and Liu J.R. Resveratrol induced autophagocytosis in ovarian cancer cells. Cancer Res 64 (2004) 696-703
28. Dörrie J., Gerauer H., Wachter Y., and Zunino S.J. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res 61 (2001) 4731-4739
29. Shimizu T., Nakazato T., Xian M.J., Sagawa M., Ikeda Y., and Kizaki M. Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways. Biochem Pharmacol 71 (2006) 742-750
30. Sareen D., van Ginkel P.R., Takach J.C., Mohiuddin A., Darjatmoko S.R., Albert D.M., et al. Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells. Invest. Ophthalmol Vis Sci 47 (2006) 3708-3716
31. Mohan J., Gandhi A.A., Bhavya B.C., Rashmi R., Karunagaran D., Indu R., et al. Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. J Biol Chem 281 (2006) 17599-17611
32. Pozo-Guisado E., Merino J.M., Mulero-Navarro S., Lorenzo-Benayas M.J., Centeno F., Alvarez-Barrientos A., et al. Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. Int J Cancer 115 (2005) 74-84
33. Nakagawa H., Kiyozuka Y., Uemura Y., Senzaki H., Shikata N., Hioki K., et al. Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator. J Cancer Res Clin Oncol 127 (2001) 258-264
34. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., and Nagata S. A caspase activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391 (1998) 43-50
35. Janicke R.U., Sprengart M.L., Wati M.R., and Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273 (1998) 9357-9360
36. Pozo-Guisado E., Alvarez-Barrientos A., Mulero-Navarro S., Santiago-Josefat B., and Fernandez-Salguero P.M. The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: cell-specific alteration of the cell cycle. Biochem Pharmacol 64 (2002) 1375-1386