Ochratoxin A reduces NMDA receptor subunits 2A and 2B concentrations in rat hippocampus: Partial protective effect of melatonin

Human and Experimental Toxicology

Volumn 22, Issue 6, 2003, Pages 335-339

  Delibas, Namik ^a   Altuntas, Irfan ^a   Yonden, Zafer ^a   Ozcelik, Nurten ^a  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Hippocampus; Melatonin; NMDA receptor; Ochratoxin A; Rat

Indexed keywords

MELATONIN; MYCOTOXIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OCHRATOXIN; RECEPTOR SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; COGNITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; FOOD CONTAMINATION; FUNGUS; HIPPOCAMPUS; LEARNING; MALE; MEMORY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HIPPOCAMPUS; MALE; MELATONIN; OCHRATOXINS; PROTECTIVE AGENTS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

ANIMALIA; FUNGI; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0038489162     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327103ht357oa     Document Type: Article

References (25)

1. Ozcelik N, Kosar A, Soysal D. Ochratoxin A in human serum samples collected in Isparta, Turkey from healthy individuals suffering from different urinary disorders. Toxicol Lett 2001; 121: 9-13.
2. Gekle M, Mildenberger S, Freudinger R, Silbernagl S. The mycotoxin ochratoxin A impairs protein uptake in cells derived from the proximal tubule of the kidney (opposum kidney cells) 1. J Pharmacol Exp Therap 1994; 271: 1-6.
3. Bozic Z, Duanncic V, Belicza M, Kraus O, Skiljarov I. Balkan endemic nephropathy: still a mysterious disease. Eur J Epidemiol 1995; 11: 235-38.
4. Gautier JC, Holzhaeuser D, Markovic J, Gremaud E, Schilter B, Turesky RJ. Oxidative damage and stress response from ochratoxin A exposure in rats. Free Rad Biol Med 2001; 30: 1089-98.
5. Belmadani A, Tramu G, Betbeder AM, Steyn PS, Creppy EE. Regional selectivity to ochratoxin A, distribution and cytotoxicity in rat brain. Arch Toxicol 1998; 72: 656-62.
6. Belmadani A, Steyn PS, Tramu G, Betbeder AM, Baudrimont I, Creppy EE. Selective toxicity of ochratoxin A in primary cultures from different brain regions. Arch Toxicol 1999; 73: 108-14.
7. Monyer H, Sprengel R, Schoepfer R. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 1992; 256: 1217-21.
8. Eckles SK, Clayton D, Bickford P. Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression. Brain Res Mol Brain Res 2000; 78: 154-62.
9. Monyer H, Burnashev N, Laurie DJ, Sakman B, Seeburg PH. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 1994; 12: 529-40.
10. Reiter RJ. Oxidative damage in the central nervous system: protection by melatonin. Progr Neurobiol 1998; 56: 359-84.
11. Antolin I, Rodriguez C, Sainz R. Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes. FASEB J 1996; 10: 882-90.
12. Monnet FT, Sorg O, Honegger P, Zurich MG, Huggett AC, Schilter B. Effects of the naturally occurring food mycotoxin ochratoxin A on brain cells in culture. Neurotoxicology 1997; 18: 831-40.
13. Subramanian S, Kanthasamy A, Balasubramanian N, Sekar N, Govindasamy S. Ochratoxin A toxicity on carbohydrate metabolism in rats. Bull Environ Contam Toxicol 1989; 43: 180-84.
14. Atroshi F, Rizzo A, Sankari S, Biese I, Westermarck T, Veijalainen P. Liver enzyme activities of rats exposed to ochratoxin A and T-2 toxin with antioxidants. Bull Environ Contam Toxicol 2000; 64: 586-92.
15. Ohta Y, Kongo M, Sasaki E, Nishida K, Ishiguro I. Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats. J Pineal Res 2000; 28: 119-26.
16. Lowry O, Rosenbrough N, Farr L. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
17. Petzinger E, Ziegler K. Ochratoxin A from a toxicological perspective. J Vet Pharmacol Therap 2000; 23: 91-98.
18. Creppy EE, Lugnier AA, Fasiolo F, Heller K, Roschenthaler R, Dirheimer G. In vitro inhibition of yeast phenylalanyl-tRNA synthetase by ochratoxin A. Chem Biol Interact 1979; 24: 257-61.
19. Dirheimer G, Creppy EE. Mechanism of action of ochratoxin A. IARC Scientific Publication 1991; 115: 171-86.
20. Bunge I, Dirheimer G, Roschenthaler R. In vivo and in vitro inhibition of protein synthesis in Bacillus stearothermophilus by ochratoxin A. Biochem Biophys Res Commun 1978; 83: 398-405.
21. Baudrimont I, Ahouandjivo R, Creppy EE. Prevention of lipid peroxidation induced by ochratoxin A in Vero cells in culture by several agents. Chem Biol Interact 1997; 104: 29-40.
22. Klann E. Cell permeable scavengers of superoxide prevent long-term potentiation in hippocampal area CA1. J Neurophysiol 1998; 80: 452-57.
23. Zeman M, Buyse J, Lamosova D, Herichova I, Decuypere E. Role of melatonin in the control of growth and growth hormone secretion in poultry. Dom Anim Endocrinol 1999; 17: 199-207.
24. Liu F, Ng TB, Fung MC. Pineal indoles stimulate the gene expression of immunomodulating cytokines. J Neural Transm 2001; 108: 397-405.
25. Jung KY, Takeda M, Kim DK, Tojo A, Narikawa S, Yoo BS, Hosoyamada M, Cha SH, Sekine T, Endou H. Characterization of ochratoxin A transport by human organic anion transporters. Life Sci 2001; 69: 2123-35.