Metabolic Fate of a New Anti-ulcer Drug (+)-(1R,4aS,10aH)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-l-phenanthrenecarboxylic Acid 6-Sodium Salt Pentahydrate (TA-2711). II. Distribution in the Rat Stomach

Journal of Pharmacobio-Dynamics

Volumn 14, Issue 9, 1991, Pages 547-554

  Ito, Yutaka ^a   Sugawara, Yoichi ^a   Takaiti, Osasi ^a   Nakamura, Susumu ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

(+) (1R,4aS,10aR) 1,2,3,4,4a,9,10,10a octahydro 1,4a dimethyl 7 (1 methylethyl) 6 sulfo 1 phenanthrenecarboxylic acid 6 sodium salt pentahydrate (TA 2711); antiulcer drug; distribution; gastric mucosa; gastric ulcer; microautoradiography; rat

Indexed keywords

12 SULFODEHYDROABIETIC ACID; ACETIC ACID; ALCOHOL; ANTIULCER AGENT; RADIOISOTOPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG BINDING; DRUG DISTRIBUTION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STOMACH; STOMACH ULCER;

ANIMALS; ANTI-ULCER AGENTS; AUTORADIOGRAPHY; DITERPENES; DITERPENES, ABIETANE; MALE; RATS; RATS, INBRED STRAINS; STOMACH; STOMACH ULCER; TISSUE DISTRIBUTION;

EID: 0026072554     PISSN: 0386846X     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb1978.14.547     Document Type: Article

References (11)

1. Y. Onoda, T. Magaribuchi and H. Tamaki: Effects of 12-sulfodehydroabietic acid monosodium salt (TA-2711), a new anti-ulcer agent, on gastric secretion and experimental ulcers in rats, Jpn. J. Pharmacol., 51, 65-73 (1989).
2. Y. Ito, T. Fukushima, Y. Sugawara, O. Takaiti and S. Nakamura: Metabolic fate of a new anti-ulcer drug (+)- (1R, 4aS, 10aR)-1, 2, 3, 4, 4a, 9, 10, 10a-octahydro-1, 4a-dimethyl-7-(1 -methylethyl)-6-sulf o-1 -phenanthr enecarboxylic acid 6-sodium salt pentahydrate (TA-2711). I. Disposition, metabolism and protein binding in rats and dogs, J. Pharmacobio-Dyn., 14, 533-546 (1991).
3. T. Tsuchiya, H. Tsuchida, S. Tojo, K. Naito and M. Otsuka: Microautoradiographic distribution of 14C-diltiazem in the dog kidney after renal arterial injection, Chem. Pharm. Bull., 26, 752-756 (1978).
4. Y. Onoda, M. Takido, T. Magaribuchi and H. Tamaki: Effects of 12-sulfodehydroabietic acid monosodium salt (TA-2711), a new anti-ulcer agent, on gastric mucosal lesions induced by necrotizing agents and gastric mucosal defensive factors in rats, Jpn. J. Pharmacol., 52, 631-638 (1990).
5. Y. Ito, S. Nakamura, Y. Sugawara and O. Takaiti: The interaction between a new anti-ulcer drug TA-2711 and albumin and the formation of the complex resistant to peptic hydrolysis, Jpn. J. Pharmacol., 55, 86P (1991).
6. B. A. Hills, B. D. Butler and L. M. Lichtenberger: Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach, Am. J. Physiol., 244, G561-568 (1983).
7. A. Ogiso, E. Kitazawa, S. Kobayashi, T. Komai, N. Matsunuma and S. Kataumi: Plaunotol (CS-684), A new anti-ulcer agent, Annu. Rep. Sankyou Res. Lab., 37, 1-39 (1985).
8. H. Tanabe, J. Sato, M. Yamamoto, T. Ota, K. Okabe, T. Ohba and T. Naruchi: Metabolic fate of anti-ulcer drug TEI-5103 (II): distribution, foeto-placental transfer and excretion into milk in Rats, Xenobio. Metabol. Dispos., 3, 13-23 (1988).
9. K. Hoshina, H. Tanabe, N. Yamazaki, M. Yamamoto, T. Ohba, T. Takesita and T. Maruchi: Effect of 3-[p-trans-4-aminoethylcyclohexylcarbonyl)phenyl]propionic acid hydrochloride on gastric mucosa directly from the lumen, Arzneim.-Forsch., 37, 1289-1295 (1987).
10. R. Nagashima, Y. Hinohara, T. Hirano, Y. Tohiro and H. Kamiyama: Selective binding of sucralfate to ulcer lesion. II. Experiments in rats with gastric ulcer receiving 14C-sucralfate or potassium 14C-sucrose sulfate, Arzneim.-Forsch., 30, 84-88 (1980).
11. R. Nagashima, N. Yoshida and N. Terao: Sucralfate, a basic aluminum salt of sucrose sulfate. II. Inhibition of peptic hydrolysis as it results from sucrose sulfate interaction with protein substrate, serum albumins, Arzneim.-Forsch., 30, 73-76 (1980).