Ecabet sodium prevents esophageal lesions induced by the reflux of gastric juice in rats

Inflammopharmacology

Volumn 15, Issue 2, 2007, Pages 90-94

  Okuyama, K ^a   Saito, N ^a   Kume, E ^a   Noto, T ^a   Nagasaki, M ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Ecabet sodium; Esophageal lesion; Esophageal mucus; Reflux of gastric juice

Indexed keywords

12 SULFODEHYDROABIETIC ACID; HISTAMINE H2 RECEPTOR ANTAGONIST; HYDROCHLORIC ACID; OMEPRAZOLE; PEPSIN A; PROTON PUMP INHIBITOR; RANITIDINE; REBAMIPIDE; TEPRENONE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ESOPHAGUS INJURY; GASTROESOPHAGEAL REFLUX; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PYLORUS LIGATION; RAT; STOMACH JUICE;

ANIMALS; ANTI-ULCER AGENTS; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ESOPHAGEAL DISEASES; ESOPHAGUS; GASTRIC JUICE; GASTROESOPHAGEAL REFLUX; MALE; MUCOUS MEMBRANE; OMEPRAZOLE; PEPSIN A; RANITIDINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34247548296     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-006-1538-0     Document Type: Article

References (15)

1. Anson, M. L. (1938). The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin. J. Gen. Physiol. 22, 78-189.
2. Armstrong, D., Talley, N. J., Lauritsen, K., Moum, B., Lind, T., Tunturi-Hihnala, H. et al. (2004). The role of acid suppression in patients with endoscopy-negative reflux disease: the effect of treatment with esomeprazole or omeprazole. Aliment Pharmacol. Ther. 20, 413-421.
3. Castell, D. O., Kahrilas, P. J., Richter, J. E., Vakil, N. B., Johnson, D. A., Zuckerman, S. et al. (2002). Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis. Am. J. Gastroenterol. 97, 575-583.
4. Corne, S. J., Morrissey, S. M., Woods, R. J. (1974). A method for the quantitative estimation of gastric barrier mucus. J. Physiol. 242, 116P-117P.
5. Folin, O., Ciocalteau, V. (1927). On tyrosine and tryptophane determinations in proteins. J. Biol. Chem, LXXIII, 627-650.
6. Goldberg, H. I., Dodds, W. J., Gee, S., Montgomery, C., Zboralske, F. F. (1969). Role of acid and pepsin in acute experimental esophagitis. Gastroenterology 56, 223-230.
7. Inatomi, N., Nagaya, H., Takami, K., Shino, A., Satoh, H. (1991). Effects of a proton pump inhibitor, AG-1749 (lansoprazole), on reflux esophagitis and experimental ulcers in rats. Jpn. J. Pharmacol. 55, 437-451.
8. Inn, H., Yamane, K., Jinnin, M., Asano, Y., Yazawa, N., Kubo, M. et al. (2002). Pharma Medica 20, 191-201.
9. Ito, Y., Nakamura, S., Onoda, Y., Sugawara, Y., Takaiti, O. (1993a). Effects of the new anti-ulcer drug ecabet sodium (TA-2711) on pepsin activity. I. Inactivation of enzyme protein. Jpn. J. Pharmacol. 62, 169-174.
10. Ito, Y., Onoda, Y., Nakamura, S., Tagawa, K., Fukushima, T., Sugawara, Y. et al. (1993b). Effects of the new anti-ulcer drug ecabet sodium (TA-2711) on pepsin activity. II. Interaction with substrate protein. Jpn. J. Pharmacol, 62,175-181.
11. Kinoshita, M., Endo, M., Yasoshima, A., Saito, N., Yamasaki, K., Chishima, S. (1999a). Ecabet sodium, a novel locally-acting anti-ulcer agent, protects the integrity of the gastric mucosal gel layer from pepsin-induced disruption in the rat. Aliment Pharmacol. Ther. 13, 687-694.
12. Kinoshita, M., Kume, E., Igarashi, S., Saito, N., Narita, H. (1999b). Role of salivary mucin in the protection of rat esophageal mucosa from acid and pepsin-induced injury. Am. J. Physiol. 277, G796-800.
13. Lanas, A. I., Blas, J. M., Ortego, J., Soria, J., Sainz, R. (1997). Adaptation of esophageal mucosa to acid- and pepsin-induced damage: role of nitric oxide and epidermal growth factor. Dig. Dis. Sci. 42, 1003-1012.
14. Lillemoe, K. D., Johnson, L. F., Harmon, J. W. (1982). Role of the components of the gastroduodenal contents in experimental acid esophagitis. Surgery 92, 276-284.
15. Omura, N., Kashiwagi, H., Chen, G., Yano, F., Suzuki, Y., Aoki, T. (2000). Effects of ecabet sodium on experimentally induced reflux esophagitis. J. Gastroenterol. 35, 504-509.