Potential neuroprotective drugs in cerebral ischemia: New saturated and polyunsaturated lipids coupled to hydrophilic moieties: Synthesis and biological activity

Journal of Medicinal Chemistry

Volumn 52, Issue 14, 2009, Pages 4358-4369

  Biraboneye, Alain César ^a   Madonna, Sébastien ^a   Laras, Younes ^a   Krantic, Slavica ^c   Maher, Pamela ^b   Kraus, Jean Louis ^a  

^a CNRS   (France)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c Turing Center for Living Systems CENTURI Aix Marseille University   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3,4 DIHYDROXY 5 OXO 2,5 DIHYDROFURAN 2 YL) 2 HYDROXYETHYL 6 OCTADECA 9,12 DIENAMIDOHEXANOIC ACID; 2 (3,7 DIMETHYL 9 (2,6,6, TRIMETHYLCYCLOHEX 1 ENYL)NONA 2,4,6,8 TETRAENAMIDO) 3 HYDROXYPROPANOIC ACID; 2 HYDROXY 1 STEARAMIDOETHYLPHOSPHONIC ACID; 2 [3,4 BIS(BENZYLOXY) 5 OXO 2,5 DIHYDROFURAN 2 YL) 2 HYDROXYETHYL 6 OCTADECA 9,12 DIENAMIDOHEXANOIC ACID; 3 HYDROXY 2 (7 ISOPROPYL 1,4A DIMETHYL 1,2,3,4A,4B,5,6,10,10A DECAHYDROPHENANTHRENE 1 CARBOXAMIDO)PROPANOIC ACID; 3 HYDROXY 2 OCTADECA 3,6,9 TRIENAMIDOPROPANOIC ACID; 3 HYDROXY 2 STEARAMIDOPROPANOIC ACID; 3 HYDROXY 2 [5 (1 HYDROXY 2,6,6 TRIMETHYL 4 OXOCYCLOHEX 2 ENYL) 3 METHYLPENTA 2,4 DIENAMIDO]PROPANOIC ACID; DIMETHYL 2 HYDROXY 1 STEARAMIDOETHYLPHOSPHONIC ACID; ETHYL 2 HEPTADECA 9,12 DIENAMIDO 2 (1H TETRAZOL 5 YL)ACETATE; ETHYL 3 HYDROXY 2 (7 ISOPROPYL 1,4A DIMETHYL 1,2,3,4A,5,6,10,10A DECAHYDROPHENANTHRENE 1 CARBOXAMIDO)PROPANOIC ACID; ETHYL 3 HYDROXY 2 ICOSA 5,8,11,14 TETRAENAMIDOPROPANOIC ACID; ETHYL 3 HYDROXY 2 OCTADECA 3.6.9 TRIENAMIDOPROPANOIC ACID; ETHYL 3 HYDROXY 2 OCTADECA 9,12 DIENAMIDOPROPANOIC ACID; ETHYL 3 HYDROXY 2 STEARAMIDOPROPANOIC ACID; ETHYL 3 HYDROXY 2 [5 (1 HYDROXY 2,6,6 TRIMETHYL 4 OXOCYCLOHEX 2 ENYL) 3 METHYLPENTA 2,4 DIENAMIDO]PROPANOIC ACID; FISETIN; FUNCTIONAL GROUP; GANGLIOSIDE GM1; GANGLIOSIDE GM1 DERIVATIVE; GLUTAMIC ACID; IODOACETIC ACID; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; N [9 (3,4 DIHYDROXY 5 OXO 2,5 DIHYDROFURAN 2 YL) 9 HYDROXY 6 OXONONYL]CERAMIDE; N [9 [3,4 BIS(BENZYLOXY) 5 OXO 2,5 DIHYDROFURAN 2 YL] 9 HYDROXY 6 OXONONYL]STEARAMIDE; NEUROPROTECTIVE AGENT; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

ARTICLE; BIOLOGICAL ACTIVITY; BRAIN CORTEX; BRAIN ISCHEMIA; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROPHILICITY; NERVE CELL NECROSIS; NEUROPROTECTION;

EID: 67650745031     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900227u     Document Type: Article

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