LEKTI-1 in sickness and in health

International Journal of Cosmetic Science

Volumn 31, Issue 4, 2009, Pages 247-254

  Roelandt, T ^a   Thys, B ^b   Heughebaert, C ^a   De Vroede, A ^a   De Paepe, K ^c   Roseeuw, D ^a   Rombaut, B ^b   Hachem, J P ^a  

^a UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c Dienst Dermatologie ^*

Author keywords

LEKTI; Serine protease; Serine protease inhibitors; SPINKS; Stratum corneum

Indexed keywords

KALLIKREIN; LYMPHO EPITHELIAL KAZAL TYPE 1 INHIBITOR; LYMPHO EPITHELIAL KAZAL TYPE 2 INHIBITOR; SERINE PROTEINASE; STRATUM CORNEUM CHYMOTRYPTIC ENZYME; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ATOPIC DERMATITIS; DESQUAMATION; GENE; HOMEOSTASIS; HUMAN; KERATINOCYTE; NETHERTON DISEASE; PATHOGENESIS; PERMEABILITY BARRIER; REVIEW; SPINK5 GENE; STRATUM CORNEUM;

ANTI-BACTERIAL AGENTS; DERMATITIS, ATOPIC; HUMANS; KALLIKREINS; PROTEINASE INHIBITORY PROTEINS, SECRETORY; RECOMBINANT PROTEINS; SERINE PROTEINASE INHIBITORS; SKIN PHYSIOLOGICAL PHENOMENA;

EID: 67650727443     PISSN: 01425463     EISSN: 14682494     Source Type: Journal    
DOI: 10.1111/j.1468-2494.2009.00516.x     Document Type: Review

References (46)

1. Hachem, J.P. The two compartment model of the stratum corneum: biochemical aspects and pathophysiological implications. Verh. K. Acad. Geneeskd. Belg. 68, 287 317 (2006).
2. Elias, P.M. Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers. Exp. Dermatol. 5, 191 201 (1996). (Pubitemid 26316184)
3. Elias, P.M. Menon, G.K. Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv. Lipid Res. 24, 1 26 (1991).
4. Demerjian, M., Hachem, J.P., Tschachler, E. et al. Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2. Am. J. Pathol. 172, 86 97 (2008). (Pubitemid 351186371)
5. Elias, P.M., Cullander, C., Mauro, T., Rassner, U., Komuves, L., Brown, B.E. Menon, G.K. The secretory granular cell: the outermost granular cell as a specialized secretory cell. J. Investig. Dermatol. Symp. Proc. 3, 87 100 (1998). (Pubitemid 29135201)
6. Ishida-Yamamoto, A., Simon, M., Kishibe, M. et al. Epidermal lamellar granules transport different cargoes as distinct aggregates. J. Invest. Dermatol. 122, 1137 1144 (2004). (Pubitemid 38651088)
7. Ishida-Yamamoto, A., Deraison, C., Bonnart, C. et al. LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum. J. Invest. Dermatol. 124, 360 366 (2005). (Pubitemid 40175883)
8. Hachem, J.P., Wagberg, F., Schmuth, M. et al. Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome. J. Invest. Dermatol. 126, 1609 1621 (2006). (Pubitemid 43910378)
9. Magert, H.J., Standker, L., Kreutzmann, P. et al. LEKTI, a novel 15-domain type of human serine proteinase inhibitor. J. Biol. Chem. 274, 21499 21502 (1999).
10. Bitoun, E., Micheloni, A., Lamant, L. et al. LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome. Hum. Mol. Genet. 12, 2417 2430 (2003). (Pubitemid 37220407)
11. Wingens, M., van Bergen, B.H., Hiemstra, P.S. et al. Induction of SLPI (ALP/HUSI-I) in epidermal keratinocytes. J. Invest. Dermatol. 111, 996 1002 (1998). (Pubitemid 29115165)
12. Schalkwijk, J., Wiedow, O. Hirose, S. The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core. Biochem. J. 340 (Pt 3 569 577 (1999). (Pubitemid 29312852)
13. Molhuizen, H.O., Alkemade, H.A., Zeeuwen, P.L., de Jongh, G.J., Wieringa, B. Schalkwijk, J. SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking. J. Biol. Chem. 268, 12028 12032 (1993).
14. Chen, C.S., Lyons-Giordano, B., Lazarus, G.S. Jensen, P.J. Differential expression of plasminogen activators and their inhibitors in an organotypic skin coculture system. J. Cell Sci. 106 (Pt 1 45 53 (1993).
15. Zeeuwen, P.L., Van Vlijmen-Willems, I.M., Jansen, B.J. et al. Cystatin M/E expression is restricted to differentiated epidermal keratinocytes and sweat glands: a new skin-specific proteinase inhibitor that is a target for cross-linking by transglutaminase. J. Invest. Dermatol. 116, 693 701 (2001). (Pubitemid 32467647)
16. Gonzalez, R., Matthew, A.D. Lange, P.H. Deviation of the prostatic urethra in pelvic masses. Surg. Gynecol. Obstet. 148, 429 430 (1979). (Pubitemid 9137842)
17. Walden, M., Kreutzmann, P., Drogemuller, K., John, H., Forssmann, W.G. Hans-Jurgen, M. Biochemical features, molecular biology and clinical relevance of the human 15-domain serine proteinase inhibitor LEKTI. Biol. Chem. 383, 1139 1141 (2002). (Pubitemid 35215060)
18. Hachem, J.P., Crumrine, D., Fluhr, J., Brown, B.E., Feingold, K.R. Elias, P.M. pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J. Invest. Dermatol. 121, 345 353 (2003). (Pubitemid 36969909)
19. Caubet, C., Jonca, N., Brattsand, M. et al. Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J. Invest. Dermatol. 122, 1235 1244 (2004). (Pubitemid 38651099)
20. Hansson, L., Stromqvist, M., Backman, A., Wallbrandt, P., Carlstein, A. Egelrud, T. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. J. Biol. Chem. 269, 19420 19426 (1994).
21. Egelrud, T. Lundstrom, A. A chymotrypsin-like proteinase that may be involved in desquamation in plantar stratum corneum. Arch. Dermatol. Res. 283, 108 112 (1991).
22. Stefansson, K., Brattsand, M., Ny, A., Glas, B. Egelrud, T. Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum. Biol. Chem. 387, 761 768 (2006). (Pubitemid 43964798)
23. Hachem, J.P., Man, M.Q., Crumrine, D. et al. Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J. Invest. Dermatol. 125, 510 520 (2005).
24. Ohman, H. Vahlquist, A. The pH gradient over the stratum corneum differs in X-linked recessive and autosomal dominant ichthyosis: a clue to the molecular origin of the "acid skin mantle"? J. Invest. Dermatol. 111, 674 677 (1998). (Pubitemid 28452332)
25. Hanson, K.M., Behne, M.J., Barry, N.P., Mauro, T.M., Gratton, E. Clegg, R.M. Two-photon fluorescence lifetime imaging of the skin stratum corneum pH gradient. Biophys. J. 83, 1682 1690 (2002). (Pubitemid 34977738)
26. Mitsudo, K., Jayakumar, A., Henderson, Y. et al. Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: a kinetic analysis. Biochemistry 42, 3874 3881 (2003). (Pubitemid 36402680)
27. Egelrud, T., Brattsand, M., Kreutzmann, P. et al. hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6. Br. J. Dermatol. 153, 1200 1203 (2005). (Pubitemid 41779577)
28. Deraison, C., Bonnart, C., Lopez, F. et al. LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction. Mol. Biol. Cell 18, 3607 3619 (2007). (Pubitemid 47378698)
29. Tartaglia-Polcini, A., Bonnart, C., Micheloni, A. et al. SPINK5, the defective gene in netherton syndrome, encodes multiple LEKTI isoforms derived from alternative pre-mRNA processing. J. Invest. Dermatol. 126, 315 324 (2006). (Pubitemid 43323166)
30. Jayakumar, A., Kang, Y., Henderson, Y. et al. Consequences of C-terminal domains and N-terminal signal peptide deletions on LEKTI secretion, stability, and subcellular distribution. Arch. Biochem. Biophys. 435, 89 102 (2005). (Pubitemid 40170020)
31. Elias, P.M. The skin barrier as an innate immune element. Semin. Immunopathol. 29, 3 14 (2007). (Pubitemid 47596384)
32. Elias, P.M. Stratum corneum defensive functions: an integrated view. J. Invest. Dermatol. 125, 183 200 (2005). (Pubitemid 41648149)
33. Braff, M.H. Gallo, R.L. Antimicrobial peptides: an essential component of the skin defensive barrier. Curr. Top. Microbiol. Immunol. 306, 91 110 (2006). (Pubitemid 47400319)
34. Wu, Z., Bartels, J. Schröder, J. Lympho-Epithelial-Kazal-type- Inhibitor 2 (LEKTI-2), a novel epithelial peptide antibiotic. Exp. Dermatol. 17, 260 (2008).
35. Chavanas, S., Bodemer, C., Rochat, A. et al. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat. Genet. 25, 141 142 (2000). (Pubitemid 30394980)
36. Fartasch, M., Williams, M.L. Elias, P.M. Altered lamellar body secretion and stratum corneum membrane structure in Netherton syndrome: differentiation from other infantile erythrodermas and pathogenic implications. Arch. Dermatol. 135, 823 832 (1999). (Pubitemid 29330807)
37. Powell, J., Dawber, R.P., Ferguson, D.J. Griffiths, W.A. Netherton's syndrome: increased likelihood of diagnosis by examining eyebrow hairs. Br. J. Dermatol. 141, 544 546 (1999). (Pubitemid 29448422)
38. Higuchi, K., Hara, J., Okamoto, R., Kawashima, M. Imokawa, G. The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. Biochem. J. (350 Pt) 3, 747 756 (2000). (Pubitemid 30763695)
39. Taieb, A. Hypothesis: from epidermal barrier dysfunction to atopic disorders. Contact Derm. 41, 177 180 (1999). (Pubitemid 29427906)
40. Walley, A.J., Chavanas, S., Moffatt, M.F. et al. Gene polymorphism in Netherton and common atopic disease. Nat. Genet. 29, 175 178 (2001). (Pubitemid 32952654)
41. Kato, A., Fukai, K., Oiso, N., Hosomi, N., Murakami, T. Ishii, M. Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population. Br. J. Dermatol. 148, 665 669 (2003). (Pubitemid 36629743)
42. Vasilopoulos, Y., Cork, M.J., Murphy, R. et al. Genetic association between an AACC insertion in the 3′UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis. J. Invest. Dermatol. 123, 62 66 (2004). (Pubitemid 38833464)
43. Palmer, C.N., Irvine, A.D., Terron-Kwiatkowski, A. et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat. Genet. 38, 441 446 (2006).
44. Rodriguez, E., Baurecht, H., Novak, N., Illig, T., Irvine, A.D. Weidinger, S. Analysis of gene-gene interaction within the filaggrin pathway (abstract 479). IID, Kyoto. J. Invest. Dermatol. (2008).
45. Komatsu, N., Saijoh, K., Kuk, C. et al. Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients. Exp. Dermatol. 16, 513 519 (2007). (Pubitemid 46845395)
46. Hachem, J.P., Houben, E., Crumrine, D. et al. Serine protease signaling of epidermal permeability barrier homeostasis. J. Invest. Dermatol. 126, 2074 2086 (2006). (Pubitemid 44244852)