Biochemical features, molecular biology and clinical relevance of the human 15-domain serine proteinase inhibitor LEKTI

Biological Chemistry

Volumn 383, Issue 7-8, 2002, Pages 1139-1141

  Walden, Michael ^a   Kreutzmann, Peter ^a   Drögemüller, Katrin ^a   John, Harald ^a   Forssmann, Wolf Georg ^a   Mägert, Hans Jürgen ^a  

^a IPF PHARMACEUTICALS GMBH   (Germany)

Author keywords

Asthma; Atopy; Kazal type; Netherton syndrome; Skin disease

Indexed keywords

SERINE PROTEINASE INHIBITOR; TRYPSIN; CARRIER PROTEIN; SPINK5 PROTEIN, HUMAN;

ASTHMA; ATOPY; BIOCHEMISTRY; CHROMOSOME 5Q; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION; GENE LOCATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC LINKAGE; HEMOFILTRATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; INHIBITION KINETICS; LINKAGE ANALYSIS; MOLECULAR BIOLOGY; MOUTH MUCOSA; NETHERTON DISEASE; PARATHYROID GLAND; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN ISOLATION; SHORT SURVEY; THYMUS; TONSIL; TRACHEA; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; REVIEW; TISSUE DISTRIBUTION;

CARRIER PROTEINS; HUMANS; MOLECULAR BIOLOGY; MUTATION; PROTEIN STRUCTURE, TERTIARY; SERINE PROTEINASE INHIBITORS; TISSUE DISTRIBUTION;

EID: 0036660696     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.124     Document Type: Short Survey

References (26)

1. Baumann, H., Morella, K.K., Campos, S.P., Cao, Z., and Jahreis, G.P. (1992). Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes. J. Biol. Chem. 267, 19744-19751.
2. Bergad, P.L., Shih, H.M., Towle, H.C., Schwarzenberg, S.J., and Berry, S.A. (1995). Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two gamma-activated sites. J. Biol. Chem. 270, 24903-24910.
3. Bode, W., and Huber, R. (1992). Natural protein proteinase inhibitors and their interaction with proteinases. Eur. J. Biochem. 204, 433-451.
4. Brattsand, M., and Egelrud, T. (1999). Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J. Biol. Chem. 274, 30033-30040.
5. 1-Antitrypsin: structure, variation and disease. Essays Med. Biochem. 4, 83-119.
6. Chavanas, S., Garner, C., Bodemer, C., Ali, M., Teillac, D.H., Wilkinson, J., Bonafe, J.L., Paradisi, M., Kelsell, D.P., Ansai, S.I. et al. (2000a). Localization of the Netherton syndrome gene to chromosome 5q32, by linkage analysis and homozygosity mapping. Am. J. Hum. Genet. 66, 914-921.
7. Chavanas, S., Bodemer, C., Rochat, A., Hamel-Teillac, D., Ali, M., Irvine, A.D., Bonafe, J.L., Wilkinson, J., Tal̈eb, A., Barrandon, Y., Harper, J.I., de Prost, Y., and Hovnanian, A. (2000b). Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nature Genet. 25, 141-142.
8. Cookson, W.O.C., and Moffat, M.F. (2000). Genetics of asthma and allergic disease. Hum. Mol. Genet. 9, 2359-2364.
9. Fritz, H. (1980). Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects. In: Protein Degradation in Health and Disease, Excerpta Médica (Ciba Foundation, Symposium 1975), pp. 351-379.
10. Greene, L.J., and Bartelt, D.C. (1969). The structure of the bovine pancreatic secretory trypsin inhibitor - Kazal's inhibitor. II. The order of the tryptic peptides. J. Biol. Chem. 244, 2646-2657.
11. Kazal, L.A., Spicer, D.S., and Brahinsky, R.A. (1948). Isolation of a crystalline trypsin inhibitor-anticoagulant protein from the pancreas. J. Am. Chem. Soc. 70, 3034-3040.
12. Kel, A., Kel-Margoulis, O., Babenko, V., and Wingender, E. (1999). Recognition of NFATp/AP-1 composite elements within genes induced upon the activation of immune cells. J. Mol. Biol. 288, 37353-37617.
13. Leung, D., Abbenante, G., and Fairlie, D.P. (2000). Protease inhibitors: current status and future prospects. J. Med. Chem. 43, 305-341.
14. Lo, K., Landau, N.R., and Smale, S.T. (1991). LyF-1, a transcriptional regulator that interacts with a novel class of promoters for lymphocyte-specific genes. Mol. Cell. Biol. 11, 5229-5243.
15. Mägert, H.J., Ständker, L., Kreutzmann, P., Zucht, H.D., Reinecke, M., Sommerhoff, C.P., Fritz, H., and Forssmann, W.G. (1999). LEKTI, a novel 15-domain type of human serine proteinase inhibitor. J. Biol. Chem. 274, 21499-21502.
16. Marks, W.H., and Ohlsson, K. (1982). Isolation and partial characterization of the pancreatic secretory trypsin inhibitor in the rat. Biochim. Biophys. Acta 717, 91-97.
17. Molnar, A., and Georgopoulos, K. (1994). The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins. Mol. Cell. Biol. 14, 8292-8303.
18. Ponnappan, U. (1998). Regulation of transcription factor NF-κB in immune senescence. Front. Biosci. 3, D152-168.
19. Seife, C. (1997). Blunting nature's Swiss army knife. Science 277, 1602-1603.
20. Sliva, D., Wood, T.J., Schindler, C., Lobie, P.E., and Norstedt, G. (1994). Growth hormone specifically regulates serine protease inhibitor gene transcription via gamma-activated sequence-like DNA elements. J. Biol. Chem. 269, 26208-26214.
21. Smith, D.L., Smith, J.G., Wong, S.W., and deShazo, R.D. (1995). Netherton's syndrome: a syndrome of elevated IgE and characteristic skin and hair findings. J. Allergy Clin. Immunol. 95, 116-123.
22. Sommerhoff, C.P., Sollner, C., Mentele, R., Piechottka, G.P., Auerswald, E.A., and Fritz, H. (1994). A Kazal-type inhibitor of human mast cell tryptase: isolation from the medical leech Hirudo medicinalis, characterization, and sequence analysis. Biol. Chem. Hoppe-Seyler 375, 685-694.
23. Walley, A.J., Chavanas, S., Moffatt, M.F., Esnouf, R.M., Ubhi, B., Lawrence, R., Wong, K., Abecasis, G.R., Jones, E.Y., Harper, J.I., Hovnanian, A., and Cookson, W.O. (2001). Gene polymorphism in Netherton and common atopic disease. Nature Genet. 29, 175-178.
24. Walter, M.A., Spillett, D.J., Thomas, P., Weissenbach, J., and Goodfellow, P.N. (1994). A method for constructing radiation hybrid maps of whole genomes. Nature Genet. 7, 22-28.
25. Wang, J.Y., Nishiyama, K., Araki, K., Kitamura, D., and Watanabe, T. (1987). Purification of an octamer sequence (ATG-CAAAT)-binding protein from human B cells. Nucleic Acids Res. 15, 10105-10116.
26. Zweidler-Mckay, P.A., Grimes, H.L., Flubacher, M.M., and Tsichlis, P.N. (1996). Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor. Mol. Cell. Biol. 16, 4024-4034.