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Volumn 9, Issue 8, 2009, Pages 1099-1106

The role of natalizumab in hematopoietic stem cell mobilization

Author keywords

Hematopoietic stem cells; Natalizumab; VLA 4

Indexed keywords

ALPHA4 INTEGRIN; ANTIBODY; BETA INTERFERON; CD34 ANTIGEN; CYTOTOXIC AGENT; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MONOCLONAL ANTIBODY; NATALIZUMAB; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

EID: 67650682526     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712590903055011     Document Type: Review
Times cited : (23)

References (64)
  • 1
    • 34250779802 scopus 로고    scopus 로고
    • Natalizumab for multiple sclerosis
    • Ransohoff RM. Natalizumab for multiple sclerosis. N Engl J Med 2007;356:2622-2629
    • (2007) N Engl J Med , vol.356 , pp. 2622-2629
    • Ransohoff, R.M.1
  • 2
    • 17644398787 scopus 로고    scopus 로고
    • Anti-α4 integrin therapy for multiple sclerosis: Mechanisms and rationale
    • Rice GP, Hartung HP, Calabresi PA. Anti-αintegrin therapy for multiple sclerosis: mechanisms and rationale. Neurology 2005;64:1336-1342 (Pubitemid 40570497)
    • (2005) Neurology , vol.64 , Issue.8 , pp. 1336-1342
    • Rice, G.P.A.1    Hartung, H.-P.2    Calabresi, P.A.3
  • 3
    • 0041334132 scopus 로고    scopus 로고
    • Therapeutic value of alpha-4 integrin blockade in inflammatory bowel disease: The role of natalizumab
    • DOI 10.1517/eobt.3.6.995.21264
    • Ghosh S. Therapeutic value of alpha-4 integrin blockade in inflammatory bowel disease:the role of natalizumab. Expert Opin Biol Ther 2003;3:995-1000 (Pubitemid 37093154)
    • (2003) Expert Opinion on Biological Therapy , vol.3 , Issue.6 , pp. 995-1000
    • Ghosh, S.1
  • 5
    • 0032081280 scopus 로고    scopus 로고
    • Mobolization and homing of peripheral blood progenitors is related to reversible downregulation of α4β1 integrin expression and function
    • Prosper F, Stroncek D, Mccarthy JB, et al. Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of α4β1 integrin expression and function. J Clin Invest 1998;101:2456-2467 (Pubitemid 28270440)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.11 , pp. 2456-2467
    • Prosper, F.1    Stroncek, D.2    McCarthy, J.B.3    Verfaillie, C.M.4
  • 6
    • 0033047022 scopus 로고    scopus 로고
    • Homing and mobilization in the stem cell niche
    • DOI 10.1016/S0962-8924(99)01559-7, PII S0962892499015597
    • Whetton AD, Graham GJ. Homing and mobilization in the stem cell niche. Trends Cell Biol 1999;9:233-238 (Pubitemid 29244135)
    • (1999) Trends in Cell Biology , vol.9 , Issue.6 , pp. 233-238
    • Whetton, A.D.1    Graham, G.J.2
  • 7
    • 0026035375 scopus 로고
    • Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis
    • Miyake K, Weissman IL, Greenberger JS, et al. Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis. J Exp Med 1991;173:599-607
    • (1991) J Exp Med , vol.173 , pp. 599-607
    • Miyake, K.1    Weissman, I.L.2    Greenberger, J.S.3
  • 8
    • 0028314503 scopus 로고
    • Roles for integrin very late activation antigen-4 in stroma-dependent erythropoiesis
    • Yanai N, Sekine C, Yagita H, et al. Roles for integrin very late activation antigen-4 in stroma-dependent erythropoiesis. Blood 1994;83:2844-2850 (Pubitemid 24142715)
    • (1994) Blood , vol.83 , Issue.10 , pp. 2844-2850
    • Yanai, N.1    Sekine, C.2    Yagita, H.3    Obinata, M.4
  • 11
    • 0025896309 scopus 로고
    • Differentiation of primitive human multipotent hematopoietic progenitors into single lineage clonogenic progenitors is accompanied by alteration in their interaction with fibronectin
    • Verfaillie CM, Mccarthy JB, Mcglave PB. Differentiation of primitive human multipotent hematopoietic progenitors into single lineage clonogenic progenitors is accompanied by alteration in their interaction with fibronectin. J Exp Med 1991;174:693-703
    • (1991) J Exp Med , vol.174 , pp. 693-703
    • Verfaillie, C.M.1    Mccarthy, J.B.2    Mcglave, P.B.3
  • 12
    • 0026688896 scopus 로고
    • Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells
    • Simmons PJ, Masinovsky B, Longenecker BM, et al. Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. Blood 1992;80:388-395
    • (1992) Blood , vol.80 , pp. 388-395
    • Simmons, P.J.1    Masinovsky, B.2    Longenecker, B.M.3
  • 13
    • 0026779726 scopus 로고
    • Role of β1 and β2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma
    • Teixido J, Hemler ME, Greenberger JS, et al. Role of β1 and β2 integrins in the adhesion of human CD34hi stem cells to bone marrow stroma. J Clin Invest 1992;90:358-367
    • (1992) J Clin Invest , vol.90 , pp. 358-367
    • Teixido, J.1    Hemler, M.E.2    Greenberger, J.S.3
  • 14
    • 0027393054 scopus 로고
    • Expression of integrins and examination of their adhesive function in normal and leukemic hematopoietic cells
    • Liesveld JL, Winslow JM, Frediani KE, et al. Expression of integrins and examination of their adhesive function in normal and leukemic hematopoietic cells. Blood 1993;81:112-121 (Pubitemid 23013684)
    • (1993) Blood , vol.81 , Issue.1 , pp. 112-121
    • Liesveld, J.L.1    Winslow, J.M.2    Frediani, K.E.3    Ryan, D.H.4    Abboud, C.N.5
  • 15
    • 0028146650 scopus 로고
    • Adhesion molecules in hematopoietic cells
    • Kinashi T, Springer TA. Adhesion molecules in hematopoietic cells. Blood Cells 1994;20:25-44
    • (1994) Blood Cells , vol.20 , pp. 25-44
    • Kinashi, T.1    Springer, T.A.2
  • 16
    • 0029561654 scopus 로고
    • + progenitor cells from bone marrow and peripheral blood during G-CSF-enhanced recovery
    • + progenitor cells from bone marrow and peripheral blood during G-CSF-enhanced recovery. Exp Hematol 1995;23:1535-1542
    • (1995) Exp Hematol , vol.23 , pp. 1535-1542
    • Möhle, R.1    Murea, S.2    Kirsch, M.3
  • 18
    • 0032147040 scopus 로고    scopus 로고
    • + progenitors in G0/G1 versus S+G2/M phases of the cell cycle
    • + progenitors in G0/G1 versus S+G2/M phases of the cell cycle. Blood 1998;92:842-848
    • (1998) Blood , vol.92 , pp. 842-848
    • Yamaguchi, M.1    Ikebuchi, K.2    Hirayama, F.3
  • 20
    • 0033896487 scopus 로고    scopus 로고
    • + haematopoietic stem cells is associated with a functional inactivation of the integrin very late antigen 4
    • DOI 10.1046/j.1365-2141.2000.02130.x
    • Lichterfeld M, Martin S, Burkly L, et al. Mobilization of CD34+ haematopoietic stem cells is associated with a functional inactivation of the integrin very late antigen 4. Br J Haematol 2000;110:71-81 (Pubitemid 30625595)
    • (2000) British Journal of Haematology , vol.110 , Issue.1 , pp. 71-81
    • Lichterfeld, M.1    Martin, S.2    Burkly, L.3    Haas, R.4    Kronenwett, R.5
  • 22
    • 0031440743 scopus 로고    scopus 로고
    • Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice
    • Craddock CF, Nakamoto B, Andrews RG, et al. Antibodies to VLA4 integrin mobilize long-term repopulating cells and augment cytokine-induced mobilization in primates and mice. Blood 1997;90:4779-4788 (Pubitemid 28007191)
    • (1997) Blood , vol.90 , Issue.12 , pp. 4779-4788
    • Craddock, C.F.1    Nakamoto, B.2    Andrews, R.G.3    Priestley, G.V.4    Papayannopoulou, T.5
  • 23
    • 0032147025 scopus 로고    scopus 로고
    • Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells
    • Vermeulen M, Lepesteur F, Gagnerault MC, et al. Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells. Blood 1998;92:894-900 (Pubitemid 28355472)
    • (1998) Blood , vol.92 , Issue.3 , pp. 894-900
    • Vermeulen, M.1    Le Pesteur, F.2    Gagnerault, M.-C.3    Mary, J.-Y.4    Sainteny, F.5    Lepault, F.6
  • 24
    • 0032055189 scopus 로고    scopus 로고
    • Anti-VLA4/VCAM-1-induced mobilization requires cooperative signaling through the kit/mkit ligand pathway
    • Papayannopoulou T, Priestley GV, Nakamoto B. Anti-VLA4/VCAM-1-induced mobilization requires cooperative signaling through the kit/mkit ligand pathway. Blood 1998;91:2231-2239 (Pubitemid 28155495)
    • (1998) Blood , vol.91 , Issue.7 , pp. 2231-2239
    • Papayannopoulou, T.1    Priestley, G.V.2    Nakamoto, B.3
  • 25
    • 0028971211 scopus 로고
    • The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen
    • Papayannopoulou T, Craddock C, Nakamoto B, et al. The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen. Proc Natl Acad Sci USA 1995;92:9647-9651
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9647-9651
    • Papayannopoulou, T.1    Craddock, C.2    Nakamoto, B.3
  • 26
    • 0028836388 scopus 로고
    • Dynamic regulation of integrins
    • Faull RJ, Ginsberg MH. Dynamic regulation of integrins. Stem Cells 1995;13:38-46
    • (1995) Stem Cells , vol.13 , pp. 38-46
    • Faull, R.J.1    Ginsberg, M.H.2
  • 27
    • 0032523064 scopus 로고    scopus 로고
    • Integrin signaling: The platelet paradigm
    • Shattil SJ, Kashiwagi H, Pampori N. Integrin signaling: the platelet paradigm. Blood 1998;91:2645-2657
    • (1998) Blood , vol.91 , pp. 2645-2657
    • Shattil, S.J.1    Kashiwagi, H.2    Pampori, N.3
  • 28
    • 0029820264 scopus 로고    scopus 로고
    • Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity
    • Huttenlocher A, Ginsberg MH, Horwitz AF. Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J Cell Biol 1996;134:1551-1562 (Pubitemid 26318026)
    • (1996) Journal of Cell Biology , vol.134 , Issue.6 , pp. 1551-1562
    • Huttenlocher, A.1    Ginsberg, M.H.2    Horwitz, A.F.3
  • 29
    • 0031750553 scopus 로고    scopus 로고
    • Modulation of integrin activity is vital for morphogenesis
    • DOI 10.1083/jcb.141.4.1073
    • Martin-Bermudo MD, Dunin-Borkowski OM, Brown NH. Modulation of integrin activity is vital for morphogenesis. J Cell Biol 1998;141:1073-1081 (Pubitemid 28243973)
    • (1998) Journal of Cell Biology , vol.141 , Issue.4 , pp. 1073-1081
    • Martin-Bermudo, M.D.1    Dunin-Borkowski, O.M.2    Brown, N.H.3
  • 30
    • 43549090004 scopus 로고    scopus 로고
    • + hematopoietic progenitor cells in humans
    • This paper reports data demonstrating the mobilizing effect of natalizumab in humans
    • + hematopoietic progenitor cells in humans. Blood 2008;111:3893-3895 • This paper reports data demonstrating the mobilizing effect of natalizumab in humans.
    • (2008) Blood , vol.111 , pp. 3893-3895
    • Zohren, F.1    Toutzaris, D.2    Klaerner, V.3
  • 31
    • 43549101765 scopus 로고    scopus 로고
    • Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab
    • This paper includes data demonstrating the mobilizing effect of natalizumab in humans
    • Bonig H, Wundes A, Chang KH, et al. Increased numbers of circulating hematopoietic stem/progenitor cells are chronically maintained in patients treated with the CD49d blocking antibody natalizumab. Blood 2008;111:3439-3441 • This paper includes data demonstrating the mobilizing effect of natalizumab in humans.
    • (2008) Blood , vol.111 , pp. 3439-3441
    • Bonig, H.1    Wundes, A.2    Chang, K.H.3
  • 32
    • 49449091143 scopus 로고    scopus 로고
    • Impact of mobilization and remobilization strategies on achieving sufficient stem cell yields for autologous transplantation
    • Pusic I, Jiang SY, Landua S, et al. Impact of mobilization and remobilization strategies on achieving sufficient stem cell yields for autologous transplantation. Biol Blood Marrow Transplant 2008;14:1045-1056
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 1045-1056
    • Pusic, I.1    Jiang, S.Y.2    Landua, S.3
  • 33
    • 33644863567 scopus 로고    scopus 로고
    • A single dose of 6 or 12 mg of pegfilgrastim for peripheral blood progenitor cell mobilization results in similar yields of CD34+progenitors in patients with multiple myeloma
    • DOI 10.1111/j.1537-2995.2006.00699.x
    • Bruns I, Steidl U, Kronenwett R, et al. A single dose of 6 or 12 mg of pegfilgrastim for peripheral blood progenitor cell mobilization results in similar yields of CD34+ progenitors in patients with multiple myeloma. Transfusion 2006;46:180-185 (Pubitemid 43381751)
    • (2006) Transfusion , vol.46 , Issue.2 , pp. 180-185
    • Bruns, I.1    Steidl, U.2    Kronenwett, R.3    Fenk, R.4    Graef, T.5    Rohr, U.-P.6    Neumann, F.7    Fischer, J.8    Scheid, C.9    Hubel, K.10    Haas, R.11    Kobbe, G.12
  • 35
    • 40249093217 scopus 로고    scopus 로고
    • + cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: Compassionate use data
    • + cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data. Bone Marrow Transplant 2008;41:331-338
    • (2008) Bone Marrow Transplant , vol.41 , pp. 331-338
    • Calandra, G.1    Mccarty, J.2    Mcguirk, J.3
  • 36
    • 53749085874 scopus 로고    scopus 로고
    • A phase II study of plerixafor (AMD3100) plus G-CSF for autologous hematopoietic progenitor cell mobilization in patients with Hodgkin lymphoma
    • Cashen A, Lopez S, Gao F, et al. A phase II study of plerixafor (AMD3100) plus G-CSF for autologous hematopoietic progenitor cell mobilization in patients with Hodgkin lymphoma. Biol Blood Marrow Transplant 2008;14:1253-1261
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 1253-1261
    • Cashen, A.1    Lopez, S.2    Gao, F.3
  • 39
    • 27644561433 scopus 로고    scopus 로고
    • Selective adhesion-molecule therapy and inflammatory bowel disease - A tale of Janus?
    • Podolsky DK. Selective adhesion-molecule therapy and inflammatory bowel disease - a tale of Janus? N Engl J Med 2005;353:1965-1968
    • (2005) N Engl J Med , vol.353 , pp. 1965-1968
    • Podolsky, D.K.1
  • 40
    • 33646373639 scopus 로고    scopus 로고
    • Natalizumab: Immune effects and implications for therapy
    • DOI 10.1002/ana.20877
    • Hauser SL, Weiner HL. Natalizumab: immune effects and implications for therapy. Ann Neurol 2006;59:731-732 (Pubitemid 43673148)
    • (2006) Annals of Neurology , vol.59 , Issue.5 , pp. 731-732
    • Hauser, S.L.1    Weiner, H.L.2
  • 41
    • 33644604292 scopus 로고    scopus 로고
    • Selective treatment of multiple sclerosis
    • Ropper AH. Selective treatment of multiple sclerosis. N Engl J Med 2006;354:965-967
    • (2006) N Engl J Med , vol.354 , pp. 965-967
    • Ropper, A.H.1
  • 46
    • 0037413468 scopus 로고    scopus 로고
    • Natalizumab for active Crohn's disease
    • Ghosh S, Goldin E, Gordon FH, et al. Natalizumab for active Crohn's disease. N Engl J Med 2003;348:24-32
    • (2003) N Engl J Med , vol.348 , pp. 24-32
    • Ghosh, S.1    Goldin, E.2    Gordon, F.H.3
  • 47
  • 48
    • 33644604292 scopus 로고    scopus 로고
    • Selective treatment of multiple sclerosis
    • Ropper AH. Selective treatment of multiple sclerosis. N Engl J Med 2006;354:965-7
    • (2006) N Engl J Med , vol.354 , pp. 965-967
    • Ropper, A.H.1
  • 49
    • 67650653334 scopus 로고    scopus 로고
    • Available from
    • Available from: http://investor.biogenidec. com/phoenix.zhtml?c=148682 & p=irol-TPME
  • 51
    • 22844439662 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis
    • DOI 10.1056/NEJMoa051782
    • Kleinschmidt-Demasters BK, Tyler KL. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 2005;353:369-374 (Pubitemid 41132341)
    • (2005) New England Journal of Medicine , vol.353 , Issue.4 , pp. 369-374
    • Kleinschmidt-DeMasters, B.K.1    Tyler, K.L.2
  • 52
    • 55449137632 scopus 로고    scopus 로고
    • Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis
    • Krumbholz M, Meinl I, Kümpfel T, et al. Natalizumab disproportionately increases circulating pre-B and B cells in multiple sclerosis. Neurology 2008;71:1350-1354
    • (2008) Neurology , vol.71 , pp. 1350-1354
    • Krumbholz, M.1    Meinl, I.2    Kümpfel, T.3
  • 53
    • 61549130275 scopus 로고    scopus 로고
    • Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function
    • Khatri BO, Man S, Giovannoni G, et al. Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function. Neurology 2009;72:402-409
    • (2009) Neurology , vol.72 , pp. 402-409
    • Khatri, B.O.1    Man, S.2    Giovannoni, G.3
  • 56
    • 0037413468 scopus 로고    scopus 로고
    • Natalizumab for active Crohn's disease
    • Ghosh S, Goldin E, Gordon FH. Natalizumab for active Crohn's disease. N Engl J Med 2003;348:24-32
    • (2003) N Engl J Med , vol.348 , pp. 24-32
    • Ghosh, S.1    Goldin, E.2    Gordon, F.H.3
  • 59
    • 84856368019 scopus 로고    scopus 로고
    • Oral small molecule inhibitor of VLA-4 overcomes adhesion mediated chemotherapy resistance of acute myeloid leukemia (AML) blasts in vitro, without impairment of normal blood cell recovery when combined with chemotherapy in vivo
    • Oral Presentation 858, San Francisco: Annual Meeting of the American Society of Hematology, 2008 abstract 858. ASH Annual Meeting Abstracts
    • Becker PS, Appelbaum FR, Chien S. Oral small molecule inhibitor of VLA-4 overcomes adhesion mediated chemotherapy resistance of acute myeloid leukemia (AML) blasts in vitro, without impairment of normal blood cell recovery when combined with chemotherapy in vivo. Oral Presentation 858, San Francisco: Annual Meeting of the American Society of Hematology, 2008 [abstract 858]. Blood (ASH Annual Meeting Abstracts) 2008;112
    • (2008) Blood , pp. 112
    • Becker, P.S.1    Appelbaum, F.R.2    Chien, S.3
  • 60
    • 39149106436 scopus 로고    scopus 로고
    • Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia
    • DOI 10.1038/sj.leu.2405017, PII 2405017
    • Matsunaga T, Fukai F, Miura S, et al. Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia. Leukemia 2008;22:353-60 This paper describes VLA 4-mediated therapy of leukemia. (Pubitemid 351250540)
    • (2008) Leukemia , vol.22 , Issue.2 , pp. 353-360
    • Matsunaga, T.1    Fukai, F.2    Miura, S.3    Nakane, Y.4    Owaki, T.5    Kodama, H.6    Tanaka, M.7    Nagaya, T.8    Takimoto, R.9    Takayama, T.10    Niitsu, Y.11
  • 61
    • 59649089647 scopus 로고    scopus 로고
    • Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia
    • Becker PS, Kopecky KJ, Wilks AN, et al. Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia. Blood 2009;113:866-874
    • (2009) Blood , vol.113 , pp. 866-874
    • Becker, P.S.1    Kopecky, K.J.2    Wilks, A.N.3
  • 62
    • 58249120680 scopus 로고    scopus 로고
    • Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma
    • Noborio-Hatano K, Kikuchi J, Takatoku M, et al. Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma. Oncogene 2009;28:231-242
    • (2009) Oncogene , vol.28 , pp. 231-242
    • Noborio-Hatano, K.1    Kikuchi, J.2    Takatoku, M.3
  • 63
    • 33745828642 scopus 로고    scopus 로고
    • The role of the α4 integrin-paxillin interaction in regulating leukocyte trafficking
    • Rose DM. The role of the α4 integrin-paxillin interaction in regulating leukocyte trafficking. Exp Mol Med 2006;38:191-195 (Pubitemid 44033230)
    • (2006) Experimental and Molecular Medicine , vol.38 , Issue.3 , pp. 191-195
    • Rose, D.M.1
  • 64
    • 65649141536 scopus 로고    scopus 로고
    • Concurrent blockade of α4-integrin and CXCR4 in hematopoietic stem/progenitor cell mobilization
    • Bonig H, Watts KL, Chang KH, et al. Concurrent blockade of α4-integrin and CXCR4 in hematopoietic stem/progenitor cell mobilization. Stem Cells 2009;27:836-837
    • (2009) Stem Cells , vol.27 , pp. 836-837
    • Bonig, H.1    Watts, K.L.2    Chang, K.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.