Effects of pregnanolone and dehydroepiandrosterone on ethanol intake in rats administered ethanol or saline during adolescence

Alcoholism: Clinical and Experimental Research

Volumn 33, Issue 7, 2009, Pages 1252-1264

  Gurkovskaya, Olga V ^a,b   Leonard, Stuart T ^b   Lewis, Peter B ^b,c   Winsauer, Peter J ^b,c  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Pharmacology and Experimental Therapeutics ^*  (United States)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Adolescence; Dehydroepiandrosterone; Ethanol Intake; Pregnanolone; Rats

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; ELTANOLONE; PRASTERONE; SACCHARIN; SODIUM CHLORIDE;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG DOSE INCREASE; DRUG EFFECT; DRUG MECHANISM; FEEDING; FOOD DEPRIVATION; GROUPS BY AGE; LONG EVANS RAT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; TASK PERFORMANCE; TASTE PREFERENCE;

AGE FACTORS; ALCOHOL DRINKING; ANIMALS; DEHYDROEPIANDROSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; MALE; PREGNANOLONE; RATS; RATS, LONG-EVANS; SODIUM CHLORIDE;

RATTUS;

EID: 67650675131     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2009.00951.x     Document Type: Article

References (59)

1. A receptor. Mol Pharmacol 71 : 461 472. (Pubitemid 46147913)
2. Ator NA, Grant KA, Purdy RH, Paul SM, Griffiths RR (1993) Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241 : 237 243. (Pubitemid 23272885)
3. Barbaccia ML, Affricano D, Trabucchi M, Purdy RH, Colombo G, Agabio R, Gessa GL (1999) Ethanol markedly increases "GABAergic" neurosteroids in alcohol-preferring rats. Eur J Pharmacol 384 : R1 R2.
4. Bowen CA, Purdy RH, Grant KA (1999) Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: effect of ethanol training dose and dosing procedure. J Pharmacol Exp Ther 289 : 405 411. (Pubitemid 29156056)
5. Boyle AE, Segal R, Smith BR, Amit Z (1993) Bidirectional effects of GABAergic agonists and antagonists on maintenance of voluntary ethanol intake in rats. Pharmacol Biochem Behav 46 : 179 182.
6. Crews FT, Morrow AL, Criswell H, Breese G (1996) Effects of ethanol on ion channels. Int Rev Neurobiol 39 : 283 367. (Pubitemid 126839977)
7. De Vry J, Slangen JL (1986) Effects of training dose on discrimination and cross-generalization of chlordiazepoxide, pentobarbital and ethanol in the rat. Psychopharmacology (Berl) 88 : 341 345. (Pubitemid 16131121)
8. Engel SR, Purdy RH, Grant KA (2001) Characterization of discriminative stimulus effects of the neuroactive steroid pregnanolone. J Pharmacol Exp Ther 297 : 489 495. (Pubitemid 32377976)
9. Fadalti M, Petraglia F, Luisi S, Bernardi F, Casarosa E, Ferrari E, Luisi M, Saggese G, Genazzani AR, Bernasconi S (1999) Changes of serum allopregnanolone levels in the first 2 years of life and during pubertal development. Pediatr Res 46 : 323 327. (Pubitemid 29400578)
10. Ford MM, Mark GP, Nickel JD, Phillips TJ, Finn DA (2007) Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice. Behav Brain Res 179 : 265 272. (Pubitemid 46497463)
11. Ford MM, Nickel JD, Phillips TJ, Finn DA (2005) Neurosteroid modulators of GABA(A) receptors differentially modulate ethanol intake patterns in male C57BL/6J mice. Alcohol Clin Exp Res 29 : 1630 1640. (Pubitemid 41395612)
12. Frank DW, Gray JE, Weaver RN (1976) Cyclodextrin nephrosis in the rat. Am J Pathol 83 : 367 374.
13. Grant BF, Dawson DA (1997) Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse 9 : 103 110. (Pubitemid 29381588)
14. Grobin AC, Matthews DB, Devaud LL, Morrow AL (1998) The role of GABA(A) receptors in the acute and chronic effects of ethanol. Psychopharmacology (Berl) 139 : 2 19. (Pubitemid 28416878)
15. Harrison NL, Majewska MD, Harrington JW, Barker JL (1987) Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex. J Pharmacol Exp Ther 241 : 346 353. (Pubitemid 17119381)
16. Hawkins JD, Graham JW, Maguin E, Abbott R, Hill KG, Catalano RF (1997) Exploring the effects of age of alcohol use initiation and psychosocial risk factors on subsequent alcohol misuse. J Stud Alcohol 58 : 280 290. (Pubitemid 27176093)
17. Hayashi T, Tadokoro S (1985) Learning retardation and enhanced ethanol preference produced by postnatal pretreatments with ethanol in adult rats. Jpn J Pharmacol 37 : 269 276. (Pubitemid 15134111)
18. Ho A, Chin AJ, Dole VP (1989) Early experience and the consumption of alcohol by adult C57BL/6J mice. Alcohol 6 : 511 515. (Pubitemid 20063153)
19. Imamura M, Prasad C (1998) Modulation of GABA-gated chloride ion influx in the brain by dehydroepiandrosterone and its metabolites. Biochem Biophys Res Commun 243 : 771 775. (Pubitemid 28414155)
20. Janak PH, Redfern JE, Samson HH (1998) The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone. Alcohol Clin Exp Res 22 : 1106 1112. (Pubitemid 28409004)
21. Kang MH, Spigelman I, Olsen RW (1998) Alteration in the sensitivity of GABA(A) receptors to allosteric modulatory drugs in rat hippocampus after chronic intermittent ethanol treatment. Alcohol Clin Exp Res 22 : 2165 2173. (Pubitemid 29031039)
22. Kumar S, Fleming RL, Morrow AL (2004) Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms. Pharmacol Ther 101 : 211 226. (Pubitemid 38340860)
23. A receptor function. Trends Pharmacol Sci 16 : 295 303.
24. Legrain S, Massien C, Lahlou N, Roger M, Debuire B, Diquet B, Chatellier G, Azizi M, Faucounau V, Porchet H, Forette F, Baulieu EE (2000) Dehydroepiandrosterone replacement administration: pharmacokinetic and pharmacodynamic studies in healthy elderly subjects. J Clin Endocrinol Metab 85 : 3208 3217. (Pubitemid 30944527)
25. Leonard ST, Gerak LR, Gurkovskaya O, Moerschbaecher JM, Winsauer PJ (2006) Effects of gamma-hydroxybutyric acid and flunitrazepam on ethanol intake in male rats. Pharmacol Biochem Behav 85 : 780 786. (Pubitemid 46149007)
26. Losel RM, Falkenstein E, Feuring M, Schultz A, Tillmann HC, Rossol-Haseroth K, Wehling M (2003) Nongenomic steroid action: controversies, questions, and answers. Physiol Rev 83 : 965 1016. (Pubitemid 36828929)
27. Mehta AK, Ticku MK (1998) Chronic ethanol administration alters the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one on the binding characteristics of various radioligands of GABAA receptors. Brain Res 805 : 88 94. (Pubitemid 29005124)
28. Mehta AK, Ticku MK (2001) Unsulfated and sulfated neurosteroids differentially modulate the binding characteristics of various radioligands of GABA(A) receptors following chronic ethanol administration. Neuropharmacology 40 : 668 675. (Pubitemid 32323989)
29. Morrow AL, Janis GC, VanDoren MJ, Matthews DB, Samson HH, Janak PH, Grant KA (1999) Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action? Alcohol Clin Exp Res 23 : 1933 1940. (Pubitemid 30027715)
30. Morrow AL, VanDoren MJ, Penland SN, Matthews DB (2001) The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res Brain Res Rev 37 : 98 109. (Pubitemid 34020724)
31. National Research Council (1996) Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington, DC.
32. Negro M, Casanova E, Chinchetru MA, Fernandez-Lopez A, Calvo P (1993) Differential effect of chronic ethanol treatment on barbiturate and steroid modulation of muscimol-binding to rat brain cortex. Neurosci Lett 158 : 83 86. (Pubitemid 23261789)
33. O'Dell LE, Purdy RH, Covey DF, Richardson HN, Roberto M, Koob GF (2005) Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats. Pharmacol Biochem Behav 81 : 543 550. (Pubitemid 40966801)
34. Olsen RW, Liang J, Cagetti E, Spigelman I (2005) Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol. Neurochem Res 30 : 1579 1588. (Pubitemid 41813722)
35. Park-Chung M, Malayev A, Purdy RH, Gibbs TT, Farb DH (1999) Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites. Brain Res 830 : 72 87. (Pubitemid 29251714)
36. Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6 : 2311 2322.
37. Porter JR, Svec F (1995) DHEA diminishes fat food intake in lean and obese zucker rats. Ann N Y Acad Sci 774 : 329 331. (Pubitemid 26140389)
38. Rassnick S, D'Amico E, Riley E, Koob GF (1993) GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol. Alcohol Clin Exp Res 17 : 124 130. (Pubitemid 23080978)
39. Robel P, Baulieu EE (1995) Dehydroepiandrosterone (DHEA) is a neuroactive neurosteroid. Ann N Y Acad Sci 774 : 82 110. (Pubitemid 26140362)
40. Rupprecht R, Holsboer F (1999) Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 22 : 410 416. (Pubitemid 29453646)
41. Samson HH (1986) Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats. Alcohol Clin Exp Res 10 : 436 442. (Pubitemid 16034366)
42. Samson HH, Tolliver GA, Pfeffer AO, Sadeghi KG, Mills FG (1987) Oral ethanol reinforcement in the rat: effect of the partial inverse benzodiazepine agonist RO15-4513. Pharmacol Biochem Behav 27 : 517 519. (Pubitemid 17107023)
43. Sanna E, Talani G, Busonero F, Pisu MG, Purdy RH, Serra M, Biggio G (2004) Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus. J Neurosci 24 : 6521 6530. (Pubitemid 38971700)
44. Schmitt U, Waldhofer S, Weigelt T, Hiemke C (2002) Free-choice ethanol consumption under the influence of GABAergic drugs in rats. Alcohol Clin Exp Res 26 : 457 462. (Pubitemid 34408710)
45. Siegmund S, Vengeliene V, Singer MV, Spanagel R (2005) Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases. Alcohol Clin Exp Res 29 : 1139 1145. (Pubitemid 41060428)
46. Silvers JM, Tokunaga S, Mittleman G, Matthews DB (2003) Chronic intermittent injections of high-dose ethanol during adolescence produce metabolic, hypnotic, and cognitive tolerance in rats. Alcohol Clin Exp Res 27 : 1606 1612. (Pubitemid 37280743)
47. Silvers JM, Tokunaga S, Mittleman G, O'Buckley T, Morrow AL, Matthews DB (2006) Chronic intermittent ethanol exposure during adolescence reduces the effect of ethanol challenge on hippocampal allopregnanolone levels and Morris water maze task performance. Alcohol 39 : 151 158. (Pubitemid 44791809)
48. Sinnott RS, Phillips TJ, Finn DA (2002) Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology (Berl) 162 : 438 447. (Pubitemid 35001908)
49. Slawecki CJ, Betancourt M (2002) Effects of adolescent ethanol exposure on ethanol consumption in adult rats. Alcohol 26 : 23 30. (Pubitemid 34219000)
50. Smith SS, Shen H, Gong QH, Zhou X (2007) Neurosteroid regulation of GABA(A) receptors: focus on the alpha4 and delta subunits. Pharmacol Ther 116 : 58 76. (Pubitemid 47391031)
51. Soderpalm AH, Hansen S (1998) Benzodiazepines enhance the consumption and palatability of alcohol in the rat. Psychopharmacology (Berl) 137 : 215 222. (Pubitemid 28277506)
52. Spivak CE (1994) Desensitization and noncompetitive blockade of GABAA receptors in ventral midbrain neurons by a neurosteroid dehydroepiandrosterone sulfate. Synapse 16 : 113 122. (Pubitemid 24086094)
53. Suzdak PD, Glowa JR, Crawley JN, Schwartz RD, Skolnick P, Paul SM (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234 : 1243 1247. (Pubitemid 17232364)
54. Tokunaga S, Silvers JM, Matthews DB (2006) Chronic intermittent ethanol exposure during adolescence blocks ethanol-induced inhibition of spontaneously active hippocampal pyramidal neurons. Alcohol Clin Exp Res 30 : 1 6. (Pubitemid 43341391)
55. Tolliver GA, Sadeghi KG, Samson HH (1988) Ethanol preference following the sucrose-fading initiation procedure. Alcohol 5 : 9 13. (Pubitemid 18177911)
56. Tolliver GA, Samson HH (1991) The influence of early postweaning ethanol exposure on oral self-administration behavior in the rat. Pharmacol Biochem Behav 38 : 575 580.
57. VanDoren MJ, Matthews DB, Janis GC, Grobin AC, Devaud LL, Morrow AL (2000) Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J Neurosci 20 : 1982 1989. (Pubitemid 30220395)
58. A receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol. Psychopharmacology (Berl) 141 : 77 82. (Pubitemid 29193298)
59. White AM, Ghia AJ, Levin ED, Swartzwelder HS (2000) Binge pattern ethanol exposure in adolescent and adult rats: differential impact on subsequent responsiveness to ethanol. Alcohol Clin Exp Res 24 : 1251 1256. (Pubitemid 30650945)