Dehydroepiandrosterone replacement administration: Pharmacokinetic and pharmacodynamic studies in healthy elderly subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 9, 2000, Pages 3208-3217

  Legrain, Sylvie ^a   Massien, Christine ^b   Lahlou, Najiba ^c   Roger, Marc ^c   Debuire, Brigitte ^d,e   Diquet, Bertrand ^d,e   Chatellier, Gilles ^e   Azizi, Michel ^b   Faucounau, Veronique ^f   Porchet, Herve ^g   Forette, Françoise ^f,h   Baulieu, Etienne Emile ⁱ  

^a BICHAT HOSPITAL   (France)

^b HÔPITAL BROUSSAIS   (France)

^c HÔPITAL SAINT VINCENT DE PAUL   (France)

^d HÔPITAL PAUL BROUSSE   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f Fondation Nationale De Gérontologie   (France)

^g Debiopharm   (France)

^h Paris Descartes University   (France)

ⁱ PSL Research University   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANEDIOL; ESTRADIOL; ESTRONE; PRASTERONE; PRASTERONE SULFATE; TESTOSTERONE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG HALF LIFE; FEMALE; HORMONE SUBSTITUTION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL;

EID: 0033694517     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.9.3208     Document Type: Article

References (47)

1. An adrenal-secreted 'androgen:' Dehydroisoandrosterone sulfate. Its metabolism and a tentative generalization on the metabolism of other steroid conjugates in man
2. Dehydroepiandrosterone and androsterone levels in human plasma. Effect of age and sex; day-to-day and diurnal variation
3. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations througthout adulthood
4. Serum dehydroepiandrosterone sulfate levels as an individual marker
5. Dehydropepiandrosterone sulfate and aging
6. The conversion in vivo of dehydroisoandrosterone sulfate to androsterone and etiocholanolone glucuronidates
7. Metabolism and interconversion of dehydroisoandrosterone and dehydroisoandrosterone sulfate
8. Marked decline in serum concentrations of adrenal C19 sex steroids precursors and conjugated androgen metabolites during aging
9. Panhypopituitarism as a model to study the metabolism of dehydroepiandrosterone (DHEA) in Humans
10. Dehydroepiandrosterone (DHEA) is a neuroactive neurosteroid
11. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids
12. Dehydroepiandrosterone (DHEA): A fountain of youth?
13. Dehydroepiandrosterone metabolism
14. Decreased adrenal androgen sensitivity to ACTH during aging
15. Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women
16. Activation of immune function by dehydroepiandrosterone (DHEA) in age-advanced men
17. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age
18. Dehydroepiandrosterone replacement in women with adrenal insufficiency
19. Actions of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) in the central nervous system (CNS): Effects on cognition and emotion in animals and humans
20. The epidemiology of DHEAS and cardiovascular disease
21. Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community based study
22. Plasma dehydroepiandrosterone sulfate in nursing home men
23. Replacement of DHEA in aging men and women: Potential remedial effects
24. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women
25. Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women
26. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: Contribution of the DHEAge study to a sociobiomedical
27. Inhibin and follicle-stimulating hormone levels in gonadotroph adenomas: Evidence of a positive correlation with tumour volume in men
28. Truncated AUC evaluates effectively the bioequivalence of drugs with long half-lives
29. Circandian variations of plasma testosterone and estrogens in normal men. A study by frequent sampling
30. Metabolism of dehydroepiandrosterone sulfate (DS) in normal women and women with high DS concentrations
31. In vivo studies of steroid dynamics in man
32. Steroid prehormones
33. Sex difference in the metabolism of dehydroepiandrosterone sulfate
34. Sex differences in the twenty-four-hour mean plasma concentration of dehydroioandrosterone (DHA) and dehydroisoandrosterone sulfate (DHAS) and the DHA to DHAS ratio in normal adults
35. The use of constant infusion of unlabeled dehydroepiandrosterone for the assessment of its metabolic clearance rate, its half-life, and its conversion into estrogens
36. Dehydroepiandrosterone: Kinetics of metabolism in normal men and women
37. Oral dehydroepiandrosterone for adrenal androgen replacement: Pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression
38. High bioavailability of DHEA administered percutaneously in the rat
39. Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects
40. Pattern of plasma dehydroepiandrosterone sulfate levels in humans from birth to adulthood: Evidence for testicular production
41. Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: Differences related to age and sex
42. Pharmaco-kinetics and dynamics of DHEA in the elderly. DHEA did not accumulate after repeated administration
43. Bone loss in elderly women prevented by ultralow doses of parenteral 17β-estradiol
44. Endogenous hormones and the risk of hip and vertebral fractures among older women
45. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen
46. 3H: A new '17β-hydroxyl pathway.'
47. Studies on testosterone metabolism. IV. Urinary 5α- and β-androstanediols and testosterone glucuronide from testosterone and dehydroisoandrosterone sulfate in normal people and hirsute women