Nucleocytoplasmic transport of luciferase gene mRNA requires CRM1/Exportin1 and RanGTPase

Medical Molecular Morphology

Volumn 42, Issue 2, 2009, Pages 70-81

  Kimura, Tominori ^a,b   Hashimoto, Iwao ^a,b   Nishikawa, Masao ^b   Yamada, Hisao ^b  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

CRM1 Exportin1; HIV 1 Rev; Luciferase gene mRNA; Nucleocytoplasmic transport; RanGTPase; TsBN2 cells

Indexed keywords

DIGOXIGENIN; EXPORTIN 1; LUCIFERASE; MESSENGER RNA; RAN PROTEIN; RNA DIRECTED DNA POLYMERASE;

ANIMAL CELL; ARTICLE; CHROMOSOME CONDENSATION; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE, TUMOR; CELL NUCLEUS; FATTY ACIDS, UNSATURATED; GENES, REV; HELA CELLS; HIV-1; HUMANS; KARYOPHERINS; LUCIFERASES, FIREFLY; NUCLEAR EXPORT SIGNALS; NUCLEAR PORE COMPLEX PROTEINS; RAN GTP-BINDING PROTEIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSFECTION;

EID: 67650670688     PISSN: 18601480     EISSN: 18601499     Source Type: Journal    
DOI: 10.1007/s00795-009-0441-3     Document Type: Article

References (43)

1. V.C. Bond M.B. Huang B. Person R. Hairston X.Y. Ye M. Saltarelli 1997 Effects of the human immunodeficiency virus type 1 Rev protein on reporter gene and host T-cell gene expression Cell Mol Biol (Noisy-Le-Grand) 43 995 1005
2. T. Kimura I. Hashimoto A. Yamamoto M. Nishikawa J.I. Fujisawa 2000 Rev-dependent association of the intron-containing HIV-1 gag mRNA with the nuclear actin bundles and the inhibition of its nucleocytoplasmic transport by latrunculin-B Genes Cells 5 289 307 (Pubitemid 30253179)
3. N. Custodio M. Carmo-Fonseca F. Geraghty H.S. Pereira F. Grosveld M. Antoniou 1999 Inefficient processing impairs release of RNA from the site of transcription EMBO J 18 2855 2866 (Pubitemid 29233957)
4. A. Kohler E. Hurt 2007 Exporting RNA from the nucleus to the cytoplasm Nat Rev Mol Cell Biol 8 761 773 (Pubitemid 47462133)
5. M.S. Rodriguez C. Dargemont F. Stutz 2004 Nuclear export of RNA Biol Cell 96 639 655 (Pubitemid 39562237)
6. M. Fornerod M. Ohno M. Yoshida I.W. Mattaj 1997 CRM1 is an export receptor for leucine-rich nuclear export signals Cell 90 1051 1060 (Pubitemid 27408519)
7. K. Stade C.S. Ford C. Guthrie K. Weis 1997 Exportin 1 (Crm1p) is an essential nuclear export factor Cell 90 1041 1050 (Pubitemid 27408518)
8. E. Izaurralde U. Kutay C. von Kobbe I.W. Mattaj D. Gorlich 1997 The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus EMBO J 16 6535 6547 (Pubitemid 27483278)
9. M.H. Malim S. Bohnlein J. Hauber B.R. Cullen 1989 Functional dissection of the HIV-1 Rev trans-activator: derivation of a trans-dominant repressor of Rev function Cell 58 205 214 (Pubitemid 19180092)
10. D.A. Mann I. Mikaelian R.W. Zemmel S.M. Green A.D. Lowe T. Kimura M. Singh P.J. Butler M.J. Gait J. Karn 1994 A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression J Mol Biol 241 193 207
11. U. Fischer J. Huber W.C. Boelens I.W. Mattaj R. Luhrmann 1995 The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs Cell 82 475 483
12. J.H. Ho G. Kallstrom A.W. Johnson 2000 Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit J Cell Biol 151 1057 1066
13. T.I. Moy P.A. Silver 2002 Requirements for the nuclear export of the small ribosomal subunit J Cell Sci 115 2985 2995 (Pubitemid 34905663)
14. A. Herold L. Teixeira E. Izaurralde 2003 Genome-wide analysis of nuclear mRNA export pathways in Drosophila EMBO J 22 2472 2483 (Pubitemid 36604986)
15. C.M. Brennan I.E. Gallouzi J.A. Steitz 2000 Protein ligands to HuR modulate its interaction with target mRNAs in vivo J Cell Biol 151 1 14
16. B.C. Jang U. Munoz-Najar J.H. Paik K. Claffey M. Yoshida T. Hla 2003 Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression J Biol Chem 278 2773 2776 (Pubitemid 36801177)
17. F. Higashino M. Aoyagi A. Takahashi M. Ishino M. Taoka T. Isobe M. Kobayashi Y. Totsuka T. Kohgo M. Shindoh 2005 Adenovirus E4orf6 targets pp32/LANP to control the fate of ARE-containing mRNAs by perturbing the CRM1-dependent mechanism J Cell Biol 170 15 20 (Pubitemid 40994091)
18. N. Kudo N. Matsumori H. Taoka D. Fujiwara E.P. Schreiner B. Wolff M. Yoshida S. Horinouchi 1999 Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region Proc Natl Acad Sci U S A 96 9112 9117 (Pubitemid 29374716)
19. T. Kimura I. Hashimoto T. Nagase J. Fujisawa 2004 CRM1-dependent, but not ARE-mediated, nuclear export of IFN-alpha1 mRNA J Cell Sci 117 2259 2270 (Pubitemid 38807494)
20. J.R. de Wet K.V. Wood M. DeLuca D.R. Helinski S. Subramani 1987 Firefly luciferase gene: structure and expression in mammalian cells Mol Cell Biol 7 725 737 (Pubitemid 17004537)
21. A. van Ooyen J. van den Berg N. Mantei C. Weissmann 1979 Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence Science 206 337 344 (Pubitemid 10244190)
22. H. Tang G.M. Gaietta W.H. Fischer M.H. Ellisman F. Wong-Staal 1997 A cellular cofactor for the constitutive transport element of type D retrovirus Science 276 1412 1415 (Pubitemid 27235408)
23. H.P. Bogerd A. Echarri T.M. Ross B.R. Cullen 1998 Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1 J Virol 72 8627 8635 (Pubitemid 28471801)
24. T. Kimura I. Hashimoto M. Nishikawa J.I. Fujisawa 1996 A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression Biochimie (Paris) 78 1075 1080 (Pubitemid 27193129)
25. T. Kimura A. Ohyama 1994 Interaction with the Rev response element along an extended stem I duplex structure is required to complete human immunodeficiency virus type 1 rev-mediated trans-activation in vivo J Biochem 115 945 952 (Pubitemid 24159921)
26. Kimura T, Hashimoto I (2004) Functional links between the steps in mRNA biogenesis and nuclear export. In: Pandalai SG (ed) Recent research developments in molecular and cellular biology. Research Signpost, Kerala, pp 197-208
27. C.A. Saavedra C.M. Hammell C.V. Heath C.N. Cole 1997 Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p Genes Dev 11 2845 2856 (Pubitemid 27481685)
28. Kimura T, Hashimoto I, Nishikawa M (2003) HIV-1 Rev protein: an RNA adapter between the cis-acting viral target site and the cellular CRM1/XPO1 nuclear export factor. In: Pandalai SG (ed) Recent research developments in biochemistry. Research Signpost, Kerala, pp 519-548
29. B. Wolff J.J. Sanglier Y. Wang 1997 Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA Chem Biol 4 139 147 (Pubitemid 27161752)
30. G.C. Otero M.E. Harris J.E. Donello T.J. Hope 1998 Leptomycin B inhibits equine infectious anemia virus Rev and feline immunodeficiency virus rev function but not the function of the hepatitis B virus posttranscriptional regulatory element J Virol 72 7593 7597 (Pubitemid 28377894)
31. M. Fornerod J. van Deursen S. van Baal A. Reynolds D. Davis K.G. Murti J. Fransen G. Grosveld 1997 The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88 EMBO J 16 807 816 (Pubitemid 27089527)
32. T. Nishimoto E. Eilen C. Basilico 1978 Premature of chromosome condensation in a ts DNA- mutant of BHK cells Cell 15 475 483 (Pubitemid 9052417)
33. T. Kadowaki D. Goldfarb L.M. Spitz A.M. Tartakoff M. Ohno 1993 Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily EMBO J 12 2929 2937
34. H. Nishitani M. Ohtsubo K. Yamashita H. Iida J. Pines H. Yasudo Y. Shibata T. Hunter T. Nishimoto 1991 Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis EMBO J 10 1555 1564 (Pubitemid 21905620)
35. S.A. Richards K.L. Carey I.G. Macara 1997 Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export Science 276 1842 1844
36. D. Gorlich U. Kutay 1999 Transport between the cell nucleus and the cytoplasm Annu Rev Cell Dev Biol 15 607 660 (Pubitemid 32250388)
37. N. Kudo B. Wolff T. Sekimoto E.P. Schreiner Y. Yoneda M. Yanagida S. Horinouchi M. Yoshida 1998 Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1 Exp Cell Res 242 540 547 (Pubitemid 28359835)
38. A.S. Zolotukhin B.K. Felber 1999 Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev J Virol 73 120 127 (Pubitemid 28565353)
39. P. Gruter C. Tabernero C. von Kobbe C. Schmitt C. Saavedra A. Bachi M. Wilm B.K. Felber E. Izaurralde 1998 TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus Mol Cell 1 649 659 (Pubitemid 128379243)
40. C. Saavedra B. Felber E. Izaurralde 1997 The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export Curr Biol 7 619 628 (Pubitemid 27408859)
41. I.W. Mattaj L. Englmeier 1998 Nucleocytoplasmic transport: the soluble phase Annu Rev Biochem 67 265 306 (Pubitemid 28411131)
42. I. Popa M.E. Harris J.E. Donello T.J. Hope 2002 CRM1-dependent function of a cis-acting RNA export element Mol Cell Biol 22 2057 2067 (Pubitemid 34224614)
43. G.C. Otero T.J. Hope 1998 Splicing-independent expression of the herpes simplex virus type 1 thymidine kinase gene is mediated by three cis-acting RNA subelements J Virol 72 9889 9896 (Pubitemid 28520855)