Splicing-independent expression of the herpes simplex virus type 1 thymidine kinase gene is mediated by three cis-acting RNA subelements

Journal of Virology

Volumn 72, Issue 12, 1998, Pages 9889-9896

  Otero, Glen C ^a   Hope, Thomas J ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; LEPTOMYCIN B; MESSENGER RNA; RNA; THYMIDINE KINASE;

ARTICLE; ENZYME ACTIVITY; GENE MAPPING; GENETIC TRANSCRIPTION; HEPATITIS B VIRUS; HERPES SIMPLEX VIRUS 1; NONHUMAN; PRIORITY JOURNAL; RNA SPLICING; RNA TRANSPORT;

EID: 0031773603     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.12.9889-9896.1998     Document Type: Article

References (30)

1. Bordonaro, M., and J. L. Nordstrom. 1994. Different mechanisms are responsible for the low accumulation of transcripts from intronless and 3′ splice site deleted genes. Biochem. Biophys. Res. Commun. 203:128-132.
2. Bray, M., S. Prasad, J. W. Dubay, E. Hunter, K.-T. Jeang, D. Rekosh, and M.-L. Hammarskjold. 1994. A small element from Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc. Natl. Acad. Sci. USA 91:1256-1260.
3. Buchman, A. R., and P. Berg. 1988. Comparison of intron-dependent and intron-independent gene expression. Mol. Cell. Biol. 8:4395-4405.
4. Donello, J. E., A. A. Beeche, G. J. Smith, G. R. Lucero, and T. J. Hope. 1996. The hepatitis B virus posttranscriptional regulatory element is composed of two subelements. J. Virol. 70:4345-4351.
5. Donello, J. E., J. E. Loeb, and T. J. Hope. 1998. The woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. J. Virol. 72:5085-5092.
6. Ernst, R. K., M. Bray, D. Rekosh, and M.-L. Hammarskjöld. 1997. Secondary structure and mutational analysis of the Mason-Pfizer monkey virus RNA constitutive transport element. RNA 3:210-222.
7. Ernst, R. K., M. Bray, D. Rekosh, and M.-L. Hammarskjöld. 1997. A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA. Mol. Cell. Biol. 17:135-144.
8. Fornerod, M., M. Ohno, M. Yoshida, and I. W. Mattaj. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90:1051-1060. [Comments.]
9. Fukuda, M., S. Asano, T. Nakamura, M. Adachi, M. Yoshida, M. Yanagida, and E. Nishida. 1997. CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390:308-311.
10. Greenspan, D. S., and S. M. Weissman. 1985. Synthesis of predominantly unspliced cytoplasmic RNAs by chimeric herpes simplex virus type 1 thymidine kinase-human β-globin genes. Mol. Cell. Biol. 5:1894-1900.
11. Hope, T. J. 1997. Viral RNA export. Chem. Biol. 4:335-344.
12. Hope, T. J., B. L. Bond, D. McDonald, N. P. Klein, and T. G. Parslow. 1991. Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type 1 Rex are functionally interchangeable and share an essential peptide motif. J. Virol. 65:6001-6007.
13. Hope, T. J., X. Huang, D. McDonald, and T. Parslow. 1990. Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif. Proc. Natl. Acad. Sci. USA 87:7787-7791.
14. Huang, J., and T. J. Liang. 1993. A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products. Mol. Cell. Biol. 13:7476-7486.
15. Huang, M. T. F., and C. M. Gorman. 1990. Intervening sequences increase efficiency of RNA 3′ processing and accumulation of cytoplasmic RNA. Nucleic Acids Res. 18:937-947.
16. Huang, Z.-M., and T. S. B. Yen. 1994. Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm. J. Virol. 68:3193-3199.
17. Huang, Z.-M., and T. S. B. Yen. 1995. Role of the hepatitis B virus post-transcriptional regulatory element in export of intronless transcripts. Mol. Cell. Biol. 15:3864-3869.
18. Liu, X., and J. E. Mertz. 1995. hnRNP L binds a cis-acting RNA sequence element that enables intron-independent gene expression. Genes Dev. 9:1766-1780.
19. Mancuso, V. A., T. J. Hope, L. Zhu, D. Derse, T. Phillips, and T. G. Parslow. 1994. Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus. J. Virol. 68: 1998-2001.
20. Ossareh-Nazari, B., F. Bachelerie, and C. Dargemont. 1997. Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science 278:141-144.
21. Otero, G. C., M. E. Harris, J. E. Donello, and T. J. Hope. 1998. Leptomycin B inhibits equine infectious anemia virus Rev and feline immunodeficiency virus Rev function but not the function of the hepatitis B virus posttranscriptional regulatory element. J. Virol. 72:7593-7597.
22. Pasquinelli, A., R. K. Ernst, E. Lund, C. Grimm, M. L. Zapp, D. Rekosh, M.-L. Hammarskjold, and J. E. Dahlberg. 1997. The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway. EMBO J. 16:7500-7510.
23. Saavedra, C., B. Felber, and E. Izaurralde. 1997. The simian retrovirus-1 CTE, unlike the HIV-1 RRE, utilises factors required for the export of cellular mRNAs. Curr. Biol. 7:619-628.
24. Sandri-Goldin, R. M. 1998. ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif. Genes Dev. 12:868-879.
25. Taagepera, S., D. McDonald, J. E. Loeb, L. L. Whitaker, A. McElroy, J. Y. J. Wang, and T. J. Hope. 1998. Nuclear-cytoplasmic shuttling of c-abl tyrosine kinase. Proc. Natl. Acad. Sci. USA 95:7457-7462.
26. Tabernero, C., A. S. Zolotukhin, A. Valentin, G. N. Pavlakis, and B. K. Felber. 1996. The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function. J. Virol. 70:5998-6011.
27. Wagner, M. J., J. A. Sharp, and W. C. Summers. 1981. Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1. Proc. Natl. Acad. Sci. USA 78:1441-1445.
28. Wolff, B., J. J. Sanglier, and Y. Wang. 1997. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem. Biol. 4:139-147.
29. Yu, X.-M., G. W. Gelembiuk, C.-Y. Wang, W.-S. Ryu, and J. E. Mertz. 1991. Expression from herpesvirus promoters does not relieve the intron requirement for cytoplasmic accumulation of human β-globin mRNA. Nucleic Acids Res. 19:7231-7234.
30. Zolotukhin, A. S., A. Valentin, G. N. Pavlakis, and B. K. Felber. 1994. Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes. J. Virol. 68:7944-7952.