Hexokinase-mitochondrial interaction in cardiac tissue: Implications for cardiac glucose uptake, the 18FDG lumped constant and cardiac protection

Journal of Bioenergetics and Biomembranes

Volumn 41, Issue 2, 2009, Pages 187-193

  Southworth, Richard ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Akt; Apoptosis; Hexokinase; Lumped constant; Mitochondria

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLUCOSE TRANSPORTER 4; HEXOKINASE; INSULIN; PROTEIN KINASE B;

APOPTOSIS; ENZYME INHIBITION; GLUCOSE TRANSPORT; HEART MUSCLE; HEART PROTECTION; HUMAN; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN PHOSPHORYLATION; REVIEW;

ANIMALS; CARDIOTONIC AGENTS; FLUORODEOXYGLUCOSE F18; GLUCOSE; GLUCOSE-6-PHOSPHATE; HEXOKINASE; HUMANS; INSULIN; MITOCHONDRIA, HEART; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; PROTO-ONCOGENE PROTEINS C-AKT; RADIOPHARMACEUTICALS;

EID: 67650665535     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-009-9207-9     Document Type: Review

References (70)

1. S Abraham B Borrebaek IL Chaikoff 1964 Effect of Dietary Carbohydrate on Glucokinase and Mannokinase Activities of Various Rat Tissues J. Nutr. 83 273 288
2. K Anflous-Pharayra ZJ Cai WJ Craigen 2007 VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles Biochim Biophys Acta 1767 136 42
3. H Ardehali RL Printz RR Whitesell JM May DK Granner 1999 Functional Interaction between the N- and C-terminal Halves of Human Hexokinase II J. Biol. Chem. 274 15986 15989
4. H Ardehali Y Yano RL Printz S Koch RR Whitesell JM May DK Granner 1996 Functional Organization of Mammalian Hexokinase II J. Biol. Chem. 271 1849 1852
5. KK Arora CR Filburn PL Pedersen 1993 Structure/function relationships in hexokinase Site-directed mutational analyses and characterization of overexpressed fragments implicate different functions for the N- and C-terminal halves of the enzyme. J. Biol. Chem. 268 18259 18266
6. KK Arora PL Pedersen 1988 Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP J Biol Chem 263 17422 17428 (Pubitemid 19029327)
7. DD Belke TS Larsen EM Gibbs DL Severson 2001 Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter Am J Physiol Endocrinol Metab 280 E420 427
8. H BeltrandelRio JE Wilson 1992 Interaction of mitochondrially bound rat brain hexokinase with intramitochondrial compartments of ATP generated by oxidative phosphorylation and creatine kinase Archives of Biochemistry and Biophysics 299 116 124
9. G Beutner A Ruck B Riede D Brdiczka 1998 Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases Biochimica et Biophysica Acta (BBA)/Biomembranes 1368 7 18 (Pubitemid 28031936)
10. MJ Birnbaum 2004 On the InterAktion between Hexokinase and the Mitochondrion. 7 781 782
11. B Borrebaek JT Haviken 1985 Some observations on mitochondrial-bound hexokinase and creatine kinase of the heart Biochem Med 33 170 9
12. Crane PD, William MP, Leon DB, Oldendorf WH (1983) Kinetics of Transport and Phosphorylation of 2-Fluoro-2-Deoxy-d-Glucose in Rat Brain. In Journal of Neurochemistry, pp. 160-167 (Pubitemid 13151621)
13. DAE Cross DR Alessi P Cohen M Andjelkovich BA Hemmings 1995 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 785 789 (Pubitemid 26004411)
14. WS da Silva WS Da Silva A Gomez-Puyou MT De Gomez-Puyou R Moreno-Sanchez FG de Felice L de Meis MF Oliveira A Galina 2004 Mitochondrial Bound Hexokinase Activity as a Preventive Antioxidant Defense: steady-state ADP formation as a regulatory mechanism of mambrane potential and reactive oxygen species generation in mitochondria J Biol Chem 279 39846 39855 (Pubitemid 39258256)
15. KA Davey PB Garlick A Warley R Southworth 2007 Immunogold labeling study of the distribution of GLUT-1 and GLUT-4 in cardiac tissue following stimulation by insulin or ischemia Am J Physiol Heart Circ Physiol 292 H2009 19
16. M de Cerqueira Cesar JE Wilson 1998 Further Studies on the Coupling of Mitochondrially Bound Hexokinase to Intramitochondrially Compartmented ATP, Generated by Oxidative Phosphorylation Archives of Biochemistry and Biophysics 350 109 117 (Pubitemid 28371175)
17. S Desagher J-C Martinou 2000 Mitochondria as the central control point of apoptosis Trends in Cell Biology 10 369 377 (Pubitemid 30612469)
18. T Doenst Q Han GW Goodwin PH Guthrie H Taegtmeyer 1998 Insulin does not change the intracellular distribution of hexokinase in rat heart Am J Physiol 275 E558 67
19. T Doenst H Taegtmeyer 1998 Profound underestimation of glucose uptake by [18F]2-deoxy-2-fluoroglucose in reperfused rat heart muscle Circulation 97 2454 62
20. PT Fueger S Heikkinen DP Bracy CM Malabanan RR Pencek M Laakso DH Wasserman 2003 Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice Am J Physiol Endocrinol Metab 285 E958 63
21. PT Fueger RS Lee-Young J Shearer DP Bracy S Heikkinen M Laakso JN Rottman DH Wasserman 2007 Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II Diabetes 56 2476 84
22. PB Garlick RA Medina R Southworth PK Marsden 1999 Differential uptake of FDG and DG during post-ischaemic reperfusion in the isolated, perfused rat heart Eur J Nucl Med 26 1353 8
23. A Gimenez-Cassina F Lim T Cerrato GM Palomo J Diaz-Nido 2009 Mitochondrial Hexokinase II Promotes Neuronal Survival and Acts Downstream of Glycogen Synthase Kinase-3 J. Biol. Chem. 284 3001 3011
24. N Goldin L Arzoine A Heyfets A Israelson Z Zaslavsky T Bravman V Bronner A Notcovich V Shoshan-Barmatz E Flescher 2008 Methyl jasmonate binds to and detaches mitochondria-bound hexokinase Oncogene 27 4636 4643
25. K Gottlob N Majewski S Kennedy E Kandel RB Robey N Hay 2001 Inhibition of early apoptotic events by Akt PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase Genes & Development 15 1406 1418 (Pubitemid 32524647)
26. SM Gray V Adams Y Yamashita SP Le J Goddardfinegold ERB McCabe 1994 Hexokinase Binding in Ischemic and Reperfused Piglet Brain Biochemical Medicine and Metabolic Biology 53 145 148
27. AE Halseth DP Bracy DH Wasserman 1999 Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo Am J Physiol Endocrinol Metab 276 E70 77
28. P Herrero Z Kisrieva-Ware CS Dence B Patterson AR Coggan D-H Han Y Ishii P Eisenbeis RJ Gropler 2007 PET Measurements of Myocardial Glucose Metabolism with 1-11C-Glucose and Kinetic Modeling J Nucl Med 48 955 964 (Pubitemid 46909924)
29. G Heusch R Schulz SH Rahimtoola 2005 Myocardial hibernation: a delicate balance Am J Physiol Heart Circ Physiol 288 H984 999
30. AK Jonassen MN Sack OD Mjos DM Yellon 2001 Myocardial Protection by Insulin at Reperfusion Requires Early Administration and Is Mediated via Akt and p70s6 Kinase Cell-Survival Signaling Circulation Research 89 1191 1198 (Pubitemid 34627878)
31. M Juhaszova S Wang DB Zorov HB Nuss M Gleichmann MP Mattson SJ Sollott 2008 The identity and regulation of the mitochondrial permeability transition pore: where the known meets the unknown Ann N Y Acad Sci 1123 197 212
32. MJ Knuuti P Nuutila U Ruotsalainen M Teras M Saraste R Harkonen A Ahonen U Wegelius A Haapanen J Bergman 1993 The Value of Quantitative Analysis of Glucose Utilization in Detection of Myocardial Viability by PET J Nucl Med 34 2068 2075 (Pubitemid 24002945)
33. IF Kodde J van der Stok RT Smolenski JW de Jong 2007 Metabolic and genetic regulation of cardiac energy substrate preference Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology 146 26 39 (Pubitemid 46186082)
34. JS Lewis P Herrero TL Sharp JA Engelbach Y Fujibayashi R Laforest A Kovacs RJ Gropler MJ Welch 2002 Delineation of Hypoxia in Canine Myocardium Using PET and Copper(II)-Diacetyl-bis(N4-Methylthiosemicarbazone) J Nucl Med 43 1557 1569 (Pubitemid 35285882)
35. AJ Liedtke B Renstrom SH Nellis 1992 Correlation between [5-3H]glucose and [U-14C]deoxyglucose as markers of glycolysis in reperfused myocardium Circulation Research 71 689 700
36. M Lindén P Gellerfors B Dean Nelson 1982 Pore protein and the hexokinase-binding protein from the outer membrane of rat liver mitochondria are identical FEBS Letters 141 189 192
37. X Liu CS Kim FT Kurbanov RB Honzatko HJ Fromm 1999 Dual Mechanisms for Glucose 6-Phosphate Inhibition of Human Brain Hexokinase J. Biol. Chem. 274 31155 31159
38. RM Lynch KE Fogarty FS Fay 1991 Modulation of hexokinase association with mitochondria analyzed with quantitative three-dimensional confocal microscopy J. Cell Biol. 112 385 395 (Pubitemid 21925994)
39. N Majewski V Nogueira P Bhaskar PE Coy JE Skeen K Gottlob NS Chandel CB Thompson RB Robey N Hay 2004 Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak Molecular Cell 16 819 830 (Pubitemid 39586539)
40. J Manchester X Kong J Nerbonne OH Lowry JC Lawrence Jr 1994 Glucose transport and phosphorylation in single cardiac myocytes: rate-limiting steps in glucose metabolism Am J Physiol 266 E326 33
41. T Matsui T Nagoshi EG Hong I Luptak K Hartil L Li N Gorovits MJ Charron JK Kim R Tian 2006 Effects of chronic Akt activation on glucose uptake in the heart Am J Physiol Endocrinol Metab 290 E789 97
42. T Matsui A Rosenzweig 2005 Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt Journal of Molecular and Cellular Cardiology 38 63 71 (Pubitemid 40038652)
43. T Matsui J Tao F del Monte K-H Lee L Li M Picard TL Force TF Franke RJ Hajjar A Rosenzweig 2001 Akt Activation Preserves Cardiac Function and Prevents Injury After Transient Cardiac Ischemia In Vivo Circulation 104 330 335 (Pubitemid 32666956)
44. S Miyamoto AN Murphy JH Brown 2008 Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II Cell Death Differ 15 521 9
45. HE Morgan MJ Henderson DM Regen CR Park 1961 Regulation of Glucose Uptake in Muscle. I. The effects of insulin and anoxia on glucose transport and phosphorylation in the isolated, perfused heart of normal rats J. Biol. Chem. 236 253 261
46. M Mueckler 1994 Facilitative glucose transporters European Journal of Biochemistry 219 713 725 (Pubitemid 24050938)
47. 99mTechnetium Labeled Annexin V. In American Journal of Transplantation, pp. 270-277 (Pubitemid 33674171)
48. M Muzi SD Freeman RC Burrows RW Wiseman JM Link KA Krohn MM Graham AM Spence 2001 Kinetic characterization of hexokinase isoenzymes from glioma cells: Implications for FDG imaging of human brain tumors Nuclear Medicine and Biology 28 107 116 (Pubitemid 32276074)
49. DD Newmeyer S Ferguson-Miller 2003 Mitochondria: Releasing Power for Life and Unleashing the Machineries of Death Cell 112 481 490 (Pubitemid 36263081)
50. CK Ng JE Holden TR DeGrado DM Raffel ML Kornguth SJ Gatley 1991 Sensitivity of myocardial fluorodeoxyglucose lumped constant to glucose and insulin American Journal of Physiology 260 H593 603
51. J Pastorino J Hoek 2008 Regulation of hexokinase binding to VDAC Journal of Bioenergetics and Biomembranes 40 171 182
52. JG Pastorino JB Hoek N Shulga 2005 Activation of Glycogen Synthase Kinase 3{beta} Disrupts the Binding of Hexokinase II to Mitochondria by Phosphorylating Voltage-Dependent Anion Channel and Potentiates Chemotherapy-Induced Cytotoxicity Cancer Res 65 10545 10554 (Pubitemid 41743749)
53. JG Pastorino N Shulga JB Hoek 2002 Mitochondrial Binding of Hexokinase II Inhibits Bax-induced Cytochrome c Release and Apoptosis J. Biol. Chem. 277 7610 7618 (Pubitemid 34953160)
54. RR Russell 3rd R Bergeron GI Shulman LH Young 1999 Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR American Journal of Physiology 277 H643 9
55. RR Russell 3rd JM Mrus JI Mommessin H Taegtmeyer 1992 Compartmentation of hexokinase in rat heart A critical factor for tracer kinetic analysis of myocardial glucose metabolism. J Clin Invest 90 1972 7
56. AP Santiago EA Chaves MF Oliveira A Galina APSA Santiago EA Chaves MF Oliveira A Galina 2008 Reactive oxygen species generation is modulated by mitochondrial kinases: correlation with mitochondrial antioxidant peroxidases in rat tissues Biochimie 90 1566 77
57. S Sebastian JE Wilson A Mulichak RM Garavito 1999 Allosteric Regulation of Type I Hexokinase: A Site-Directed Mutational Study Indicating Location of the Functional Glucose 6-Phosphate Binding Site in the N-Terminal Half of the Enzyme Archives of Biochemistry and Biophysics 362 203 210 (Pubitemid 29394348)
58. Sokoloff L, Reivich M, Kennedy C, Rosiers MHD, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M (1977) The 14C-deoxyglucose method for the measurement of local cerebral glucose utlisation: theory, procedure, and normal values in the conscious and anesthetised albino rat. In Journal of Neurochemistry, pp. 897-916. (Pubitemid 8098854)
59. R Southworth KA Davey A Warley PB Garlick 2007 A reevaluation of the roles of hexokinase I and II in the heart Am J Physiol Heart Circ Physiol 292 H378 86
60. R Southworth JL Dearling RA Medina AA Flynn RB Pedley PB Garlick 2002 Dissociation of glucose tracer uptake and glucose transporter distribution in the regionally ischaemic isolated rat heart: application of a new autoradiographic technique Eur J Nucl Med Mol Imaging 29 1334 41
61. R Southworth PB Garlick 2003 Dobutamine responsiveness, PET mismatch, and lack of necrosis in low-flow ischemia: is this hibernation in the isolated rat heart? Am J Physiol Heart Circ Physiol 285 H316 24
62. Southworth R, Parry CR, Parkes HG, Medina RA, Garlick PB (2003) Tissue-specific differences in 2-fluoro-2-deoxyglucose metabolism beyond FDG-6-P: a 19F NMR spectroscopy study in the rat. In NMR in Biomedicine, pp. 494-502. (Pubitemid 38072570)
63. WC Stanley FA Recchia GD Lopaschuk 2005 Myocardial Substrate Metabolism in the Normal and Failing Heart Physiol. Rev. 85 1093 1129 (Pubitemid 40894649)
64. D Sui JE Wilson 1997 Structural Determinants for the Intracellular Localization of the Isozymes of Mammalian Hexokinase: Intracellular Localization of Fusion Constructs Incorporating Structural Elements from the Hexokinase Isozymes and the Green Fluorescent Protein Archives of Biochemistry and Biophysics 345 111 125 (Pubitemid 27374215)
65. R Tian ED Abel 2001 Responses of GLUT4-Deficient Hearts to Ischemia Underscore the Importance of Glycolysis Circulation 103 2961 2966 (Pubitemid 32578135)
66. SR Underwood JJ Bax J v Dahl MY Henein AC van Rossum ER Schwarz J-L Vanoverschelde EE v d Wall W Wijns 2004 Imaging techniques for the assessment of myocardial hibernation: Report of a Study Group of the European Society of Cardiology Eur Heart J 25 815 836 (Pubitemid 38684148)
67. C Vogt H Yki-Jarvinen P Iozzo R Pipek M Pendergrass J Koval H Ardehali R Printz D Granner R DeFronzo 1998 Effects of Insulin on Subcellular Localization of Hexokinase II in Human Skeletal Muscle in Vivo J Clin Endocrinol Metab 83 230 234 (Pubitemid 28498341)
68. JE Wilson 2003 Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function J Exp Biol 206 2049 2057 (Pubitemid 36761808)
69. V Zaha R Nitschke H Gobel U Fischer-Rasokat C Zechner T Doenst 2005 Discrepancy between GLUT4 translocation and glucose uptake after ischemia Mol Cell Biochem 278 129 37
70. CJ Zuurbier O Eerbeek AJ Meijer 2005 Ischemic preconditioning, insulin, and morphine all cause hexokinase redistribution Am J Physiol Heart Circ Physiol 289 H496 9