In Vivo Imaging of Acute Cardiac Rejection in Human Patients Using 99mTechnetium Labeled Annexin V

American Journal of Transplantation

Volumn 1, Issue 3, 2001, Pages 270-277

  Kown, Murray H ^a   Strauss, H William ^a   Blankenberg, Francis G ^a   Berry, Gerald J ^a   Stafford Cecil, Sandy ^a   Tait, Jonathan F ^b   Goris, Michael L ^a   Robbins, Robert C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Stanford University Medical School ^*

Author keywords

Acute rejection; Apoptosis; Heart transplantation; Nuclear imaging

Indexed keywords

DIAGNOSTIC AGENT; LIPOCORTIN 5; TECHNETIUM;

APOPTOSIS; ARTICLE; BIOPSY; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMAN; MALE; MIDDLE AGED; NICK END LABELING; PATHOLOGY; SCINTISCANNING;

ANNEXIN A5; APOPTOSIS; BIOPSY; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IN SITU NICK-END LABELING; MALE; MIDDLE AGED; TECHNETIUM;

EID: 0035453221     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-6143.2001.001003270.x     Document Type: Article

References (42)

1. Hosenpud JD, Bennett LE, Keck BM, Fiol B, Boucek MM, Novick RJ. The Registry of the International Society for Heart and Lung Transplantation: sixteenth official report - 1999. J Heart Lung Transplant 1999; 18: 611.
2. Barry WH. Mechanisms of immune-mediated myocyte injury. Circulation 1994; 89: 2421.
3. Hetts SW. To die or not to die: an overview of apoptosis and its role in disease [see comments]. J Am Med Assoc 1998; 279: 300.
4. Kabelitz D. Apoptosis, graft rejection, and transplantation tolerance. Transplantation 1998; 65: 869.
5. Kageyama Y, Li XK, Suzuki S et al. Apoptosis is involved in acute cardiac allograft rejection in rats. Ann Thorac Surg 1998; 65: 1604.
6. Shaddy RE. Apoptosis in heart transplantation. Coron Artery Dis 1997; 8: 617.
7. Akiyama K, Gluckman TL, Terhakopian A et al. Apoptosis in experimental myocardial infarction in situ and in the perfused heart in vitro. Tissue Cell 1997; 29: 733.
8. Gopal S, Narasimhan U, Day JD et al. The Quilty lesion enigma: focal apoptosis/necrosis and lymphocyte subsets in human cardiac allografts. Pathol Int 1998; 48: 191.
9. Majno G, Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death [see comments]. Am J Pathol 1995; 146: 3.
10. Laguens RP, Meckert PM, Martino JS, Perrone S, Favaloro R. Identification of programmed cell death (apoptosis) in situ by means of specific labeling of nuclear DNA fragments in heart biopsy samples during acute rejection episodes. J Heart Lung Transplant 1996; 15: 911.
11. Szabolcs M, Michler RE, Yang X et al. Apoptosis of cardiac myocytes during cardiac allograft rejection. Relation to induction of nitric oxide synthase. Circulation 1996; 94: 1665.
12. Zwaal RF, Schroit AJ. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997; 89: 1121.
13. Blankenberg FG, Strauss HW. Non-invasive diagnosis of acute heart-or lung-transplant rejection using radiolabeled annexin V. Pediatr Radiol 1999; 29: 299.
14. van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry 1998; 31: 1.
15. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 1994; 84: 1415.
16. Vriens PW, Blankenberg FG, Stoot JH et al. The use of technetium Tc 99m annexin V for in vivo imaging of apoptosis during cardiac allograft rejection. J Thorac Cardiovasc Surg 1998; 116: 844.
17. Valantine HA, Schroeder JS. Cardiac transplantation. Intensive Care Med 1989; 15: 283.
18. Billingham ME. Endomyocardial biopsy diagnosis of acute rejection in cardiac allografts. Prog Cardiovasc Dis 1990; 33: 11.
19. Moidl R, Chevtchik O, Simon P et al. Noninvasive monitoring of peak filling rate with acoustic quantification echocardiography accurately detects acute cardiac allograft rejection. J Heart Lung Transplant 1999; 18: 194.
20. Hoff SJ, Stewart JR, Frist WH et al. Noninvasive detection of acute rejection in a new experimental model of heart transplantation. Ann Thorac Surg 1993; 56: 1074.
21. Carrier M. Noninvasive assessment of cardiac transplant rejection. A critical look at the approach to acute rejection. Can J Surg 1991; 34: 569.
22. Ravanat C, Archipoff G, Beretz A, Freund G, Cazenave JP, Freyssinet JM. Use of annexin-V to demonstrate the role of phosphatidylserine exposure in the maintenance of haemostatic balance by endothelial cells. Biochem J 1992; 282: 7.
23. Tait JF, Smith C. Site-specific mutagenesis of annexin V: role of residues from Arg-200 to Lys-207 in phospholipid binding. Arch Biochem Biophys 1991; 288: 141.
24. Kasina S, Rao TN, Srinivasan A et al. Development and biologic evaluation of a kit for preformed chelate technetium-99m radiolabeling of an antibody Fab fragment using a diamide dimercaptide chelating agent. J Nucl Med 1991; 32: 1445.
25. Billingham ME, Cary NR, Hammond ME et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant 1990; 9: 587.
26. Phelps E, Wu P, Bretz J, Baker JRJ. Thyroid cell apoptosis. A new understanding of thyroid autoimmunity. Endocrinol Metab Clin North Am 2000; 29: 375-388.
27. Ohtsuki K, Akashi K, Aoka Y et al. Technetium-99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis. Eur J Nucl Med 1999; 26: 1251.
28. Puig M, Ballester M, Matias-Guiu X et al. Burden of myocardial damage in cardiac allograft rejection: scintigraphic evidence of myocardial injury and histologic evidence of myocyte necrosis and apoptosis. J Nucl Cardiol 2000; 7: 132-139.
29. van Heerde WL, Robert-Offerman S, Dumont E et al. Markers of apoptosis in cardiovascular tissues: focus on Annexin V. Cardiovasc Res 2000; 45: 549.
30. Bergese SD, Klenotic SM, Wakely ME, Sedmak DD, Orosz CG. Apoptosis in murine cardiac grafts. Transplantation 1997; 63: 320.
31. Kanoh M, Takemura G, Misao J et al. Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair. Circulation 1999; 99: 2757.
32. Sloop GD, Roa JC, Delgado AG, Balart JT, Hines IIM, Hill JM. Histologic sectioning produces TUNEL reactivity. Arch. Pathol Lab Med 1999; 123: 529.
33. Jollow KC, Sundstrom JB, Gravanis MB, Kanter K, Herskowitz A, Ansari AA. Apoptosis of mononuclear cell infiltrates in cardiac allograft biopsy specimens questions studies of biopsy-cultured cells. Transplantation 1997; 63: 1482.
34. Brunner-La Rocca HP, Sutsch G, Schneider J, Follath F, Kiowski W. Natural course of moderate cardiac allograft rejection (International Society for Heart Transplantation grade 2) early and late after transplantation. Circulation 1996; 94: 1334.
35. Frigerio M, Bonacina E, Gronda E et al. A semiquantitative approach to the evaluation of acute cardiac allograft rejection at endomyocardial biopsy. J Heart Lung Transplant 1997; 16: 1087.
36. Hausen B, Rohde R, Demertzis S, Albes JM, Wahlers T, Schafers HJ. Strategies for routine biopsies in heart transplantation based on 8-year results with more than 13,000 biopsies. Eur J Cardiothorac Surg 1995; 9: 592.
37. Hutter JA, Wallwork J, English TA. Management of rejection in heart transplant recipients: does moderate rejection always require treatment? J Heart Transplant 1990; 9: 87.
38. Novitzky D, Rose AG, Cooper DK, Reichart B. Interpretation of endomyocardial biopsy after heart transplantation. Potentially confusing factors. S Afr Med J 1986; 70: 789.
39. Winters GL, Loh E, Schoen FJ. Natural history of focal moderate cardiac allograft rejection. Is treatment warranted? Circulation 1995; 91: 1975.
40. Winters GL. The challenge of endomyocardial biopsy interpretation in assessing cardiac allograft rejection. Curr Opin Cardiol 1997; 12: 146.
41. Ciliberto GR, Mascarello M, Gronda E et al. Acute rejection after heart transplantation: noninvasive echocardiographic evaluation. J Am Coll Cardiol 1994; 23: 1156.
42. White JA, Guiraudon C, Pflugfelder PW, Kostuk WJ. Routine surveillance myocardial biopsies are unnecessary beyond one year after heart transplantation. J Heart Lung Transplant 1995; 14: 1052.