Synthesis, antimalarial evaluation and molecular modeling studies of hydroxyethylpiperazines, potential aspartyl protease inhibitors, Part 2

European Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2009, Pages 3816-3820

  Cunico, Wilson ^a,b   Gomes, Claudia R B ^a   Facchinetti, Victor ^a   Moreth, Marcele ^a   Penido, Carmen ^a   Henriques, Maria G M O ^a   Varotti, Fernando P ^a,c   Krettli, Luisa G ^a   Krettli, Antoniana U ^a,c   da Silva, Franklin S ^a   Caffarena, Ernesto R ^a   de Magalhães, Camila S ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Hydroxyethylamine; Malaria; Protease inhibitor

Indexed keywords

ASPARTIC PROTEINASE INHIBITOR; CHLOROQUINE; LOPINAVIR; PIPERAZINE DERIVATIVE; PLASMEPSIN II;

ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; ASPARTIC ACID ENDOPEPTIDASES; CELL LINE; ERYTHROCYTES; ETHANOLAMINES; HUMANS; MACROPHAGES; MALARIA, FALCIPARUM; MODELS, MOLECULAR; MONOCYTES; MURINAE; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTOZOAN PROTEINS;

EID: 67650627751     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.041     Document Type: Article

References (20)

1. Cunico W., Carvalho S.A., Gomes C.R.B., and Marques G.H. Rev. Bras. Farm. 89 (2008) 49
2. Coombs G.H., Goldberg D.E., Klemba M., Berry C., Kay J., and Mottram J.C. Trends Parasitol. 17 (2001) 532
3. Ersmark K., Samuelsson B., and Hallberg A. Med. Res. Rev. 26 (2006) 626
4. Boss C., Richard-Bildstein S., Weller T., Fischli W., Meyer S., and Binkert C. Curr. Med. Chem. 10 (2003) 883
5. Parikh S., Gut J., Istvan E., Goldberg D.E., Havlir D.V., and Rosenthal P.J. Antimicrob. Agents Chemother. 49 (2005) 2983
6. Andrews K.T., Fairlie D.P., Madala P.K., Ray J., Wyatt D.M., Hilton P.M., Melville L.A., Beattie L., Gardioner D.L., Reid R.C., Stoermer M.J., Skinner-Adams T., Berry C., and McCarthy J.S. Antimicrob. Agents Chemother. 50 (2006) 639
7. Hidaka K., Kimura T., Tsuchiya Y., Kamiya M., Ruben A.J., Freire E., Hayashi Y., and Kiso Y. Bioorg. Med. Chem. Lett. 17 (2007) 3048
8. Abdel-Rahman H.M., Kimura T., Hidaka K., Kiso A., Nezami A., Freire E., Hayashi Y., and Kiso Y. Biol. Chem. 385 (2004) 1035
9. Noteberg D., Hamelink E., Hultén J., Wahlgren M., Vrang L., Samuelsson B., and Hallberg A. J. Med. Chem. 46 (2003) 734
10. Muthas D., Noteberg D., Sabnis Y.A., Hamelink E., Vrang L., Samuelsson B., Karlén A., and Hallberg A. Bioorg. Med. Chem. 13 (2005) 5371
11. Cunico W., Ferreira M.L.G., Ferreira T.G., Penido C., Henriques M.G.M.O., Krettli L.G., Varotti F.P., and Krettli A.U. Lett. Drug Des. Discov. 5 (2008) 178
12. Cunico W., Gomes C.R.B., Moreth M., Manhanini D.P., Figueiredo I.H., Penido C., Henriques M.G.M.O., Varotti F.P., and Krettli A.U. Eur. J. Med. Chem. 44 (2009) 1363
13. Cunico W., Cechinel C.A., Bonacorso H.G., Martins M.A.P., Zanatta N., de Souza M.V.N., Freitas I.O., Soares R.P.P., and Krettli A.U. Bioorg. Med. Chem. Lett. 16 (2006) 649
14. de Andrade-Neto V.F., Goulart M.O.F., da Silva Filho J.F., da Silva M.J., Pinto M.C.F.R., Pinto A.V., Zalis M.G., Carvalho L.H., and Krettli A.U. Bioorg. Med. Chem. Lett. 14 (2004) 1145
15. Desjardins R.E., Canfield C.J., Haynes J.D., and Chulay J.D. Antimicrob. Agents Chemother. 16 (1979) 710
16. Ferrari M., Fornasiero M.C., and Isetta A.M. J. Immunol. Methods 131 (1990) 165
17. Morris G.M., Goodsell D.S., Halliday R.S., Huey R., Hart W.E., Belew R.K., and Olson A.J. J. Comput. Chem. 19 (1998) 1639
18. Kasam V., Zimmermann M., Maa A., Schwichtenberg H., Wolf A., Jacq N., Breton V., and Hofmann-Apitius M. J. Chem. Inf. Model. 47 (2007) 1818
19. Åqvist J., Medina C., and Samuelsson J.E. Prot. Eng. 7 (1994) 385
20. Solomon V.R., Puri S.K., Srivastava K., and Katti S.B. Bioorg. Med. Chem. 13 (2005) 2157