Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15Ink4b-deficient mice

Oncogene

Volumn 22, Issue 58, 2003, Pages 9265-9274

  Wolff, Linda ^a   Garin, Matthew T ^a   Koller, Richard ^a   Bies, Juraj ^a,e   Liao, Wei ^a,f   Malumbres, Marcos ^b   Tessarollo, Lino ^c   Powell, Douglas ^d   Perella, Christine ^c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c SAIC FREDERICK INC   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e CANCER RESEARCH INSTITUTE   (Slovakia)

^f UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Hypermethylation; Ink4b; Myeloid leukemia; Retrovirus; Tumor suppressor

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2B; CYCLIN DEPENDENT KINASE INHIBITOR; MESSENGER RNA; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; CPG ISLAND; EXON; GENE DELETION; GENE LOCUS; GENE LOSS; GENE TARGETING; LEUKEMIA CELL LINE; METHYLATION; MOUSE; MOUSE STRAIN; MYELOID LEUKEMIA; MYELOMONOCYTIC LEUKEMIA; NEWBORN; NONHUMAN; NULL ALLELE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETROVIRUS; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CPG ISLANDS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; EXONS; GENE DELETION; GENOTYPE; INTRONS; LEUKEMIA, MYELOCYTIC, ACUTE; MICE; MICE, TRANSGENIC; PHENOTYPE; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0742282005     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207092     Document Type: Article

References (31)

1. Amanullah A, Hoffman B and Liebermann DA. (2000). Blood, 96, 475-482.
2. Bonin A, Reid SW and Tessarollo L. (2001). Methods Mol. Biol., 158, 121-134.
3. Cameron EE, Bachman KE, Myohanen S, Herman JG and Baylin SB. (1999a). Nat. Genet., 21, 103-107.
4. Cameron EE, Baylin SB and Herman JG. (1999b). Blood, 94, 2445-2451.
5. Chin L, Pomerantz J and DePinho RA. (1998). Trends Biochem. Sci., 23, 291-296.
6. Drexler HG. (1998). Leukemia, 12, 845-859.
7. Fekete E. (1938). Am. J. Pathol., 14, 557-578.
8. Hannon GJ and Beach D. (1994). Nature, 371, 257-261.
9. Haviernik P, Schmidt M, Hu X and Wolff L. (2003). Oncogene, 22, 1600-1610.
10. Herman JG, Graff JR, Myohanen S, Nelkin BD and Baylin SB. (1996). Proc. Natl. Acad. Sci. USA, 93, 9821-9826.
11. Jones PA and Laird PW. (1999). Nat. Genet., 21, 163-167.
12. Kalbfleisch JD and Prentice RL. (1980). The Statistical Analysis of Failure Time Data. Wiley and Sons: New York, pp. 16-19.
13. Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G and Sherr CJ. (1997). Cell, 91, 649-659.
14. Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF and Morse III HC. (2002). Blood, 100, 238-245.
15. Krimpenfort P, Quon KC, Mooi WJ, Loonstra A and Berns A. (2001). Nature, 413, 83-86.
16. Latres E, Malumbres M, Sotillo R, Martin J, Ortega S, Martin-Caballero J, Flores JM, Cordon-Cardo C and Barbacid M. (2000). EMBO J., 19, 3496-3506.
17. Li L-C and Dahiya R. (2002). Bioinformatics, 18, 1427-1431.
18. Malumbres M, Perez deC I, Santos J, Melendez B, Mangues R, Serrano M, Pellicer A and Fernandez-Piqueras J. (1997). Oncogene, 14, 1361-1370.
19. Nazarov V, Hilbert D and Wolff L. (1994). Virology, 205, 479-485.
20. Rowe WP, Pugh WE and Hartley JW. (1970). Virology, 42, 1136-1139.
21. Ruas M and Peters G. (1998). Biochim. Biophys. Acta, 1378, F115-F177.
22. Ryan KM, Phillips AC and Vousden KH. (2001). Curr. Opin. Cell Biol., 13, 332-337.
23. Schmidt M, Koller R, Haviernik P, Bies J, Maciag K and Wolff L. (2001). Oncogene, 20, 6205-6214.
24. Schmidt M, Nazarov V, Stevens L, Watson R and Wolff L. (2000). Mol. Cell. Biol., 20, 1970-1981.
25. Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW and DePinho RA. (2001). Nature, 413, 86-91.
26. Sherr CJ. (2001). Nat. Rev. Mol. Cell Biol., 2, 731-737.
27. Stirewalt DL and Radich JP. (2000). Hematology, 5, 15-25.
28. Teofili L, Morosetti R, Martini M, Urbano R, Putzulu R, Rutella S, Pierelli L, Leone G and Larocca LM. (2000). Exp. Hematol., 28, 519-526.
29. Tessarollo L. (2001). Methods Mol. Biol., 158, 47-63.
30. Wolff L, Schmidt M, Koller R, Haviernik P, Watson R, Bies J and Maclag K. (2001). Blood Cells Mol. Dis., 27, 422-428.
31. Wolff L, Koller R, Hu X and Anver MR. (2003). J. Virol., 77, 4965-4971.