Local conformations and competitive binding affinities of single-and double-stranded primer-template DNA at the polymerization and editing active sites of DNA polymerases

Journal of Biological Chemistry

Volumn 284, Issue 25, 2009, Pages 17180-17193

  Datta, Kausiki ^a   Johnson, Neil P ^b   LiCata, Vince J ^c   von Hippel, Peter H ^a  

^a UNIVERSITY OF OREGON   (United States)

^b INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^c LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2-AMINOPURINE; ACTIVE SITE; AT-WAVELENGTH; CIRCULAR DICHROISM SPECTRA; COMPETITIVE BINDING; CONFORMATIONAL CHANGE; CONTROL EXPERIMENTS; DNA POLYMERASE; DNA REPLICATIONS; DNA SYNTHESIS; EQUILIBRIUM DISTRIBUTIONS; EXONUCLEASE; PRIMER STRAND; TEMPLATE STRAND; X-RAY STRUCTURE;

BINDING ENERGY; BINDING SITES; DICHROISM; GENES; NUCLEIC ACIDS; POLYMERS;

DNA;

2 AMINOPURINE; ADENINE; DNA BASE; DNA FRAGMENT; DNA POLYMERASE; DOUBLE STRANDED DNA; KLENOW DNA POLYMERASE; KLENTAQ DNA POLYMERASE; PRIMER DNA; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA BINDING; DNA CONFORMATION; DNA SEQUENCE; DNA SYNTHESIS; DNA TEMPLATE; ENZYME ACTIVE SITE; GENE CONSTRUCT; GENETIC LINKAGE; NOMENCLATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; SPECTROFLUOROMETRY;

BASE SEQUENCE; BINDING, COMPETITIVE; CALCIUM; CATALYTIC DOMAIN; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DNA; DNA POLYMERASE I; DNA PRIMERS; DNA, SINGLE-STRANDED; DNA-DIRECTED DNA POLYMERASE; MACROMOLECULAR SUBSTANCES; MAGNESIUM; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION;

EID: 67650559447     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.007641     Document Type: Article

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