Preparation, characterization, and in vitro cytotoxicity study of cationic PCL-Pluronic-PCL (PCFC) nanoparticles for gene delivery

Journal of Biomedical Materials Research - Part A

Volumn 90, Issue 2, 2009, Pages 506-513

  Zhao, Jian ^a   Gou, MaLing ^a   Dai, Mei ^a   Li, XingYi ^a   Cao, Mei ^a   Huang, MeiJuan ^a   Wen, YanJun ^a   Kan, Bing ^a   Qian, ZhiYong ^a   Wei, YuQuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Cationic nanoparticles; Cytotoxicity; DNA degradation; DNA delivery; Poly( caprolactone) pluronic poly( caprolactone)

Indexed keywords

ACIDIC DEGRADATION; CAPROLACTONE; CATIONIC NANOPARTICLES; CETYL TRIMETHYL AMMONIUM BROMIDES; DNA DEGRADATION; DNA DELIVERY; ENZYMATIC DEGRADATION; GENE DELIVERY; IN-VITRO; MODIFIED EMULSION; PLURONIC; POLY(E-CAPROLACTONE); POTENTIAL APPLICATIONS; RELEASE BEHAVIORS;

AMMONIUM COMPOUNDS; CYTOTOXICITY; DEGRADATION; DNA; DRUG THERAPY; EMULSIFICATION; GENE TRANSFER; GENES; NUCLEIC ACIDS; PROTONIC CERAMIC FUEL CELLS (PCFC); RING OPENING POLYMERIZATION;

NANOPARTICLES;

CATION; COPOLYMER; DNA; NANOPARTICLE; POLYCAPROLACTONE;

ARTICLE; BACTERIAL GENE; CYTOTOXICITY; EMULSION; ENZYMATIC DEGRADATION; EVAPORATION; GENE TARGETING; IN VITRO STUDY; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; RING OPENING; SURFACE PROPERTY; SYNTHESIS;

CATIONS; CELL LINE; DNA; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MATERIALS TESTING; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; NANOTECHNOLOGY; PLASMIDS; POLYESTERS; POLYETHYLENES; POLYPROPYLENES;

EID: 67650497919     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31950     Document Type: Article

References (33)

1. Perez C, Sanchez A, Putnam D, Ting D, Langer R, Alonso MJ. Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J Control Release 2001;75:211-224.
2. Dachs GU, Dougherty GJ, Stratford IJ, Chaplin DJ. Targeting gene therapy to cancer: A review. Oncol Res 1997;9:313-325.
3. Edelstein ML, Abedi MR, Wixon J, Edelstein RM. Gene therapy clinical trials worldwide. 1989-2004 - An overview. J Gene Med 2004;6:597-602.
4. Roth JA, Cristiano RJ. Gene therapy for cancer: What have we done and where are we going? J Natl Cancer Inst 1997;89: 21-39.
5. Yang H, Kao WYJ. Dendrimers for biomedical and pharmaceutial applications. J Biomater Sci Polym Ed 2006;17:3-19.
6. Yang H, Lopina ST. Penicillin V-conjugated PEG-PAMAM star polymers. J Biomater Sci Polym Ed 2003;14:1043-1056.
7. Li J, Yang C, Li HZ, Wang X, Goh SH, Ding JL, Wang DY, Leong KW. Cationic supramolecules composed of multiple oligoethylenimine-Grafted b-cyclodextrins threaded on a polymer chain for efficient gene delivery. Adv Mater 2006;18: 2969-2974.
8. Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: The art of turning infectious agents into vehicles of therapeutics. Nature Med 2001;7:33-40.
9. Ando S, Putnam D, Pack DW, Langer R. PLGA microspheres containing plasmid DNA: Preservation of super-coiled DNA via cryopreparation and carbohydrate stabilization. J Pharm Sci 1999;88:126-130.
10. Park TG, Jeong JH, Kim SW. Current status of polymeric gene delivery systems. Adv Drug Deliv Rev 2006;58:467-486.
11. Dang JM, Leong KW. Natural polymers for gene delivery and tissue engineering. Adv Drug Deliv Rev 2006;58:487-499.
12. Smedt SCD, Demeester J, Hennink WE. Cationic polymer based gene delivery systems. Pharm Res 2000;17:113-125.
13. Han SO, Mahato RI, Sung YK, Kim SW. Development of bio-materials for gene therapy. Mol Ther 2000;2:302-317.
14. Singh M, Briones M, Ott G, O'Hagan DT. Cationic microparticles: A potent delivery sustem for DNA vaccines. Proc Natl Acad Sci USA 2000;97:811-816.
15. Langer R, Tirrell DA. Designing materials for biology and medicine. Nature 2004;428:487-492.
16. Edlund U, Albertsson AC. Degradable polymer microspheres for controlled drug delivery. Adv Polym Sci 2002;157:67-112.
17. Holland SJ, Tighe BF, Gould PL. Polymers for biodegradable medical devices. I. The potential of polyesters as controlled macromolecular release systems. J Control Release 1986;4: 155-180.
18. Kabanov AV, Lemieux P, Vinogradov S, Alakhov V. Pluronic (R) block copolymers: Novel functional molecules for gene therapy. Adv Drug Deliv Rev 2002;54:223-233.
19. Otsuka H, Nagasaki Y, Kataoka K. PEGylated nanoparticles for biological and pharmaceutical applications. Adv Drug Deliv Rev 2003;55:403-419.
20. Moghimi SM, Hunter AC, Murray JC. Long-circulating and target-specific nanoparticles: Theory to oractice. Pharmacol Rev 2001;53:283-318.
21. Huang MJ, Gou ML, Huang AL, Kan B, Yang JL, Tu MJ, Wei YQ, Qian ZY. One-step preparation of PCL-PEG-PCL (PCEC) nanoparticles for plasmid DNA delivery. J Biomed Mater Res A 2008;86:979-986.
22. St. Paul. DNA condensation. Curr Opin Struct Biol 1996;6: 334-341.
23. Cui ZR, Qiu F, Sloat BR. Lecithin-based cationic nanoparticles as a potential DNA delivery system. Int J Pharm 2006;313: 206-213.
24. Singh M, Ugozzoli M, Briones M, Kazzaz J, Soenawan E, O'Hagan DT. The effect of CTAB concentration in cationic PLG microparticles on DNA adsorption and in vivo performance. Pharm Res 2003;20:247-251.
25. Briones M, Singh M, Ugozzoli M, Kazzaz J, Klakamp S, Ott G, O'Hagan D. The preparation, characterization, and evaluation of cationic microparticles for DNA vaccine delivery. Pharm Res 2001;18:709-712.
26. Cui ZR, Mumper RJ. Topical immunization using nanoengineered genetic vaccines. J Control Release 2002;81:173-184.
27. Prabha S, Zhou WZ, Panyam J, Labhasetwar V. Size-dependency of nanoparticle-mediated gene transfection: Studies with fractionated nanoparticles. Int J Pharm 2002;244:105-115.
28. Pang SW, Park HY, Jang YS, Kim WS, Kim JH. Effects of charge density and particles size of poly(styrene/(dimethylamino) ethyl methacrylate) nanoparticles for gene delivery in 293 cells. Colloids Surf B 2002;26:213-222.
29. Ha JC, Kim SY, Lee YM. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (Pluronic)/poly(ε-caprolactone) (PCL) amphiphilic block copolymeric nanospheres. I. Preparation and characterization. J Control Release 1999;62:381-399.
30. Liu CB, Gong CY, Pan YF, Zhang YD, Wang JW, Wang YS, Wang K, Gou ML, Tu MJ, Wei YQ, Qian ZY. Synthesis and characterization of a thermosensitive hydrogel based on biodegradable amphiphilic PCL-Pluronic (L35)-PCL block copolymers. Colloid Surf A 2007;302(1-3):430-438.
31. Xiang JJ, Tang JQ, Zhu SG, Nie XM, Lu HB, Shen SR, Li XL, Tang K, Zhou M, Li GY. IONP-PLL: A novel non-viral vector for efficient gene delivery. J Gene Med 2003;5:803-817.
32. Kim TH, Jin H, Kim HW, Cho MH, Cho CS. Mannosylated chitosan nanoparticle-based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells. Mol Cancer Ther 2006;5:1723-1732.
33. Jia WJ, Liu JG, Zhang YD, Wang JW, Wang J, Sun CY, Pan YF, Yu C, Li GZ, Zhang H, Gou ML, Tu MJ, Qian ZY. Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres. J Drug Target 2007;15:140-145.