Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 27, 2009, Pages 11125-11130

  Page, Lesley J ^a   Ji, Young Suk ^a   Bazhenova, Lyudmila ^a   Fleming, Sheila M ^b   Wood, Malcolm ^a   Jiang, Yun ^c   Guo, Ling T ^c   Mizisin, Andrew P ^c   Kisilevsky, Robert ^d   Shelton, G Diane ^c   Balch, William E ^a   Kelly, Jeffery W ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d QUEEN S UNIVERSITY   (Canada)

Author keywords

Amyloid; FAF mouse; Proteostasis; Sporadic inclusion body myositis

Indexed keywords

AMYLOID; CELL PROTEIN; GELSOLIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; FAMILIAL AMYLOIDOSIS; HOMEOSTASIS; HOMOZYGOSITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN SYNTHESIS;

AMYLOID; AMYLOIDOSIS, FAMILIAL; ANIMALS; CAPILLARIES; GELSOLIN; HOMEOSTASIS; HOMOZYGOTE; HUMANS; INTRACELLULAR SPACE; MICE; MICE, TRANSGENIC; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE WEAKNESS; MUTANT PROTEINS; MYOSITIS, INCLUSION BODY; PEPTIDE FRAGMENTS; PHENOTYPE; PROTEIN STRUCTURE, QUATERNARY; VACUOLES;

MUS;

EID: 67650497775     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811753106     Document Type: Article

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