Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2009, Pages 3798-3804

  Husain, Asif ^a   Ahmad, Ausaf ^b   Alam, M M ^a   Ajmal, Mohd ^a   Ahuja, Priyanka ^a  

^a HAMDARD UNIVERSITY   (India)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

1,3,4 Oxadiazole; Analgesic; Antiinflammatory; Fenbufen; Lipid peroxidation; Ulcerogenic

Indexed keywords

3 [5 (3,4 DIMETHOXYPHENYL) 1,3,4 OXADIAZOL 2 YL] 1 (BIPHENYL 4 YL)PROPAN 1 ONE; 3 [5 (4 METHOXYPHENYL) 1,3,4 OXADIAZOL 2 YL] 1 (BIPHENYL 4 YL)PROPAN 1 ONE; ACETIC ACID; CARRAGEENAN; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DICLOFENAC; FENBUFEN; MALONALDEHYDE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INFRARED SPECTROSCOPY; LIPID PEROXIDATION; MASS SPECTROMETRY; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ULCEROGENESIS; WRITHING TEST;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE INHIBITORS; FEMALE; LIPID PEROXIDATION; MALE; MICE; OXADIAZOLES; PAIN MEASUREMENT; PHENYLBUTYRATES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; STOMACH; ULCER;

EID: 67650461974     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.04.009     Document Type: Article

References (27)

1. Sorbera L.A., Lesson P.A., Castanar J., and Castanar R.M. Drugs Future 26 (2001) 133-140
2. Palomer A., Cabre F., Pascual J., Campos J., Trugillo M.A., Entrena A., Gallo M.A., Garcia L., Macleon D., and Espinosa A. J. Med. Chem. 45 (2002) 1402-1411
3. Allison M.C., Howatson A.G., Torrance C.J., Lee F.D., and Russell R.I.G. N. Engl. J. Med. 327 (1992) 749-754
4. Verrico M.M., Weber R.J., McKaveney T.P., Ansani N.T., and Towers A.L. Ann. Pharmacother. 37 (2003) 1203-1213
5. Dogne J.M., Supuran C.T., and Pratico D. J. Med. Chem. 48 (2005) 2251-2257
6. In: Testa B., and Jenner P. (Eds). Drug Metabolism, Chemical and Biochemical Aspect (1976), Marcel Dekker Inc, New York 138
7. Khan M.S.Y., and Husain A. Pharmazie 57 (2002) 448-452
8. Husain A., Khan M.S.Y., Hasan S.M., and Alam M.M. Eur. J. Med. Chem. 40 (2005) 1394-1404
9. Amir M., and Shikha K. Eur. J. Med. Chem. 39 (2004) 535-545
10. Kalgutkar A.S., Marnett A.B., Crews B.C., Remmel R.P., and Marnett L.J. J. Med. Chem. 43 (2000) 2860-2870
11. Kalgutkar A.S., Crews B.C., Rowlinson S.W., Garner C., Seibert K., and Marnett L.J. Science 280 (1998) 1268-1270
12. Duflos M., Nourrisson M.R., Brelet J., Courant J., Le Baut G., Grimaud N., and Petit J.Y. Eur. J. Med. Chem. 36 (2001) 545-553
13. Burbuliene M.M., Jakubkiene V., Mekuskiene G., Udrenaite E., Smicius R., and Vainilavicius P. Farmaco 59 (2004) 767-774
14. Nargund I.V.G., Reddy G.R.N., and Hariprasad V. J. Pharm. Sci. 83 (2006) 246-248
15. Narayana B., Vijayaraj K.K., Ashalatha B.V., and Kumari N.S. Arch. Pharm. (Weinheim) 338 (2005) 373-377
16. Zarghi A., Tabatabai S.A., Faizi M., Ahadian A., Navabi P., Zanganeh V., and Shafiee A. Bioorg. Med. Chem. Lett. 15 (2005) 1863-1865
17. Tan T.M., Chen Y., Kong K.H., Bai J., Li Y., Lim S.G., Ang T.H., and Lam Y. Bioorg. Med. Chem. Lett. 16 (2006) 5036-5040
18. Srivastava R.M., Almeida L.A., Vianna O.S., Silva M.J., Catanho M.T., and Morris J.O. Bioorg. Med. Chem. 11 (2003) 1821-1827
19. Maslat A.O., Abussaud M., Tashtoush H., and Al-Talib M. Pol. J. Pharmacol. 54 (2002) 55-59
20. Yadav M.R., Shirude S.T., Puntambekar D.S., Patel P.J., Prajapati H.B., Parmar A., Balaraman R., and Giridhar R. Acta Pharm. 57 (2007) 13-30
21. Winter C.A., Risley E.A., and Nuss G.W. Proc. Soc. Exp. Biol. Med. 111 (1962) 544-547
22. Seigmund E., Cadmus R., and Lu G. Proc. Soc. Exp. Biol. Med. 95 (1957) 729-733
23. Cioli V., Putzolu S., Rossi V., Barcellona P.S., and Corradino C. Toxicol. Appl. Pharmacol. 50 (1979) 283-289
24. Pohle T., Brzozowski T., Becker J.C., Vander Voort I.R., Markmann A., Konturek S.J., Moniczewski A., Domschke W., and Konturek J.W. Aliment. Pharmacol. Ther. 15 (2001) 677-687
25. Ohkawa H., Ohishi N., and Yagi K. Anal. Biochem. 95 (1979) 351-358
26. Jashim Uddin M., Praveen Rao P.N., and Knaus E.K. Bioorg. Med. Chem. 12 (2004) 5929-5940
27. Furniss B., Hannaford A.H., Smith P.W.G., and Tatchell A.R. Vogel's Text Book of Practical Organic Chemistry. fifth ed (1998), Addison Wesley Longman, New Delhi p. 1077