Brain regional distribution of GABAA receptors exhibiting atypical GABA agonism: Roles of receptor subunits

Neurochemistry International

Volumn 55, Issue 6, 2009, Pages 389-396

  Halonen, Lauri M ^a   Sinkkonen, Saku T ^a   Chandra, Dev ^b   Homanics, Gregg E ^b   Korpi, Esa R ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

35S TBPS autoradiography; Cerebellum; GABAA receptor; Gaboxadol; Partial agonism; Thalamus; THIP

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; RECEPTOR SUBUNIT; SULFUR 35; TERT BUTYLBICYCLOPHOSPHOROTHIOATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN CELL; BRAIN TISSUE; CELL GRANULE; CONTROLLED STUDY; FOREBRAIN; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RECEPTOR BINDING; THALAMUS; TISSUE DISTRIBUTION;

ANIMALS; AUTORADIOGRAPHY; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; BRAIN; BRAIN MAPPING; GAMMA-AMINOBUTYRIC ACID; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURAL INHIBITION; PROTEIN SUBUNITS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SULFUR RADIOISOTOPES;

MUS; RATTUS;

EID: 67650236312     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.04.008     Document Type: Article

References (49)

1. A receptor channel. J. Gen. Physiol. 129 (2007) 145-159
2. A receptors. Curr. Pharm. Des. 13 (2007) 3169-3177
3. A receptors reduces actions of alcohol and other drugs. J. Pharmacol. Exp. Ther. 304 (2003) 30-36
4. A receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol. Eur. J. Pharmacol. 541 (2006) 158-162
5. A receptors suggest differential targeting of receptor subtypes. J. Neurosci. 19 (1999) 2960-2973
6. A receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 15230-15235
7. A receptors comprised of α1β3 and β3 subunits expressed in human embryonic kidney 293 cells. Br. J. Pharmacol. 120 (1997) 899-909
8. Ebert B., Wafford K.A., Whiting P.J., Krogsgaard-Larsen P., and Kemp J.A. Molecular pharmacology of γ-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different α, β, and γ receptor subunit combinations. Mol. Pharmacol. 46 (1994) 957-963
9. A receptor subtypes requires the γ2 subunit and gephyrin. Nat. Neurosci. 1 (1998) 563-571
10. A receptors. Nat. Rev. Neurosci. 6 (2005) 215-229
11. - uptake in rat cerebrocortical membranes. Mol. Pharmacol. 39 (1991) 394-398
12. A receptors. J. Biol. Chem. 284 (2009) 7889-7896
13. A receptor α subunit. Mol. Pharmacol. 44 (1993) 87-92
14. Korpi E.R., Kuner T., Seeburg P.H., and Luddens H. Selective antagonist for the cerebellar granule cell-specific γ-aminobutyric acid type A receptor. Mol. Pharmacol. 47 (1995) 283-289
15. Kralic J.E., Sidler C., Parpan F., Homanics G.E., Morrow A.L., and Fritschy J.M. Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of γ-aminobutyric acid type A receptor α1 subunit knockout mice. J. Comp. Neurol. 495 (2006) 408-421
16. A agonists and partial agonists: THIP (gaboxadol) as a non-opioid analgesic and a novel type of hypnotic. Biochem. Pharmacol. 68 (2004) 1573-1580
17. A receptors from mice lacking the γ2 subunit. J. Physiol. 527 (2000) 11-31
18. A/benzodiazepine receptor subtypes. J. Neurosci. 15 (1995) 6957-6962
19. Mäkelä R., Uusi-Oukari M., Homanics G.E., Quinlan J.J., Firestone L.L., Wisden W., and Korpi E.R. Cerebellar γ-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines. Mol. Pharmacol. 52 (1997) 380-388
20. Mihalek R.M., Banerjee P.K., Korpi E.R., Quinlan J.J., Firestone L.L., Mi Z.P., Lagenaur C., Tretter V., Sieghart W., Anagnostaras S.G., Sage J.R., Fanselow M.S., Guidotti A., Spigelman I., Li Z., DeLorey T.M., Olsen R.W., and Homanics G.E. Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor δ subunit knockout mice. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 12905-12910
21. A receptors: molecular determinants and significance in health and disease. Neurochem. Int. 52 (2008) 588-595
22. A receptors in the crosshairs of hormones and ethanol. Neurochem. Int. 52 (2008) 60-64
23. A receptors. Eur. J. Neurosci. 26 (2007) 657-665
24. A receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J. Chem. Neuroanat. 3 (1990) 59-76
25. Peng, Z., Chandra, D., Homanics, G.E., Olsen, R.W., Houser, C.R., 2007. Multiple changes in GABAA receptor subunit localization in the thalamus of an α4 subunit-deficient mouse. Program No. 350.1/F5. 2007 Neuroscience Meeting Planner. Society for Neuroscience, San Diego, CA, 2007 (online).
26. A receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101 (2000) 815-850
27. A receptor: agonist/antagonist efficacy of 4-PIOL. Eur. J. Pharmacol. 409 (2000) 233-242
28. Richerson G.B., and Wu Y. Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore. J. Neurophys. 90 (2003) 1363-1374
29. A receptors. J. Neurochem. 105 (2008) 338-350
30. A receptor subtypes. Pharmacol. Rev. 47 (1995) 181-234
31. Sinkkonen S.T., Mihalek R.M., Homanics G.E., Lüddens H., and Korpi E.R. Altered atypical coupling of γ-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines. Mol. Brain Res. 86 (2001) 179-183
32. Sinkkonen S.T., Uusi-Oukari M., Tupala E., Sarkioja T., Tiihonen J., Panula P., Lüddens H., and Korpi E.R. Characterization of γ-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions. Mol. Brain Res. 86 (2001) 168-178
33. A receptors in a genetic mouse model of anxiety. Neurochem. Int. 44 (2004) 539-547
34. Aergic inhibition in a mouse model. Eur. J. Neurosci. 20 (2004) 2168-2178
35. 35S]t-butylbicyclophosphorothionate binding sites modulated by several allosteric ligands of γ-aminobutyric acid type A receptors. Mol. Pharmacol. 48 (1995) 385-391
36. A receptors. Trends Pharmacol. Sci. 16 (1995) 162-168
37. 35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to γ-aminobutyric acid-A and ion recognition sites. Mol. Pharmacol. 23 (1983) 326-336
38. A receptors: functional selectivity for extrasynaptic receptors is dependent on the absence of γ2. J. Pharmacol. Exp. Ther. 316 (2006) 1351-1359
39. 35S]-t-butylbicyclophosphorothionate binding sites in cortex and cerebellum. Pharmacol. Biochem. Behav. 21 (1984) 151-158
40. Tossman U., Jonsson G., and Ungerstedt U. Regional distribution and extracellular levels of amino acids in rat central nervous system. Acta Physiol. Scand. 127 (1986) 533-545
41. A receptor. Neuroscience 95 (2000) 795-806
42. A receptor α1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J. Neurosci. 21 (2001) 3009-3016
43. Wafford K.A., and Ebert B. Gaboxadol-a new awakening in sleep. Curr. Opin. Pharmacol. 6 (2006) 30-36
44. A receptors containing the α4 subunit. Mol. Pharmacol. 50 (1996) 670-678
45. A δ-subunit-containing receptors. Eur. J. Neurosci. 25 (2007) 1893-1899
46. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12 (1992) 1040-1062
47. A receptor α6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition. Neuropharmacology 43 (2002) 530-549
48. A receptor channel-lining residues probed in cysteine mutants. Biophys. J. 69 (1995) 1858-1867
49. Zhang, N., Chandra, D., Homanics, G.E., Houser, C.R., 2007. Ultrastructural localization of the δ subunit of the GABAA receptor in the mouse thalamus and its alterations in α4 subunit-deficient mice. Program No. 350.2/F6. 2007 Neuroscience Meeting Planner. Society for Neuroscience, San Diego, CA, 2007 (online).