Antibiotic resistance in Mycobacterium tuberculosis. Peroxidase intermediate bypass causes poor isoniazid activation by the S315G mutant of M. tuberculosis catalase-peroxidase (KatG)

Journal of Biological Chemistry

Volumn 284, Issue 24, 2009, Pages 16146-16155

  Suarez, Javier ^a,b   Ranguelova, Kalina ^a,b,d   Schelvis, Johannes P M ^c,e   Magliozzo, Richard S ^a,b  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c NEW YORK UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e MONTCLAIR STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; ANTIBIOTIC RESISTANCE; ARTIFICIAL SUBSTRATES; BINDING AFFINITIES; CATALASE ACTIVITY; CATALASE-PEROXIDASE; CATALYTIC INTERMEDIATES; CATION-RADICAL; ENZYME STRUCTURES; GLOBAL HEALTH; IN-VITRO; M. TUBERCULOSIS; MUTANT ENZYMES; MYCOBACTERIUM TUBERCULOSIS; NICOTINAMIDE ADENINE DINUCLEOTIDE; PEROXIDASE ACTIVITIES; PEROXIDATION; RAPID EVOLUTION; RESONANCE RAMAN SPECTROSCOPY; SPECIFIC INTERACTION; TUBERCULOSIS INFECTION;

AMIDES; BINDING ENERGY; CATALYTIC OXIDATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYMES; HEMOGLOBIN; HYDRAZINE; OXIDATION; PORPHYRINS; RAMAN SPECTROSCOPY;

PLANTS (BOTANY);

ACYLNICOTINAMIDE ADENINE DINUCLEOTIDE; HEME DERIVATIVE; ISONIAZID; KATG PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERICIDAL ACTIVITY; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVATION; DRUG OXIDATION; DRUG PROTEIN BINDING; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENE MUTATION; GENE OVEREXPRESSION; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PEROXIDATION; PRIORITY JOURNAL; RAMAN SPECTROMETRY; ULTRAVIOLET SPECTROPHOTOMETRY; WILD TYPE;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CALORIMETRY; CATALASE; DRUG RESISTANCE, BACTERIAL; ENZYME ACTIVATION; ESCHERICHIA COLI; ISONIAZID; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; PEROXIDASES; SPECTRUM ANALYSIS, RAMAN; SUBSTRATE SPECIFICITY; TEMPERATURE; TITRIMETRY;

MYCOBACTERIUM TUBERCULOSIS;

EID: 67650218401     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.005546     Document Type: Article

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