Ubiquitylation on canonical and non-canonical sites targets the transciption factor neurogenin for ubiquitin-mediated proteolysis

Journal of Biological Chemistry

Volumn 284, Issue 23, 2009, Pages 15458-15468

  Vosper, Jonathan M D ^a,b   McDowell, Gary S ^a   Hindley, Christopher J ^a   Fiore Heriche, Christelle S ^a   Kucerova, Romana ^a   Horan, Ian ^a   Philpott, Anna ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIXES; CYSTEINE RESIDUES; ISOPEPTIDE BOND; LYSINE RESIDUES; N-TERMINAL; NATIVE PROTEINS; NEURONAL DIFFERENTIATION; POLYUBIQUITIN; POLYUBIQUITYLATION; PROTEASOME; UBIQUITIN; UBIQUITIN LIGASES; UBIQUITIN-MEDIATED PROTEOLYSIS; UBIQUITYLATION; XENOPUS LAEVIS;

AMINO ACIDS; DEGRADATION; ENZYMES; TRANSCRIPTION FACTORS;

BIODEGRADATION;

LYSINE; NEUROGENIN 1; POLYUBIQUITIN; PROTEASOME; UBIQUITIN PROTEIN LIGASE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; METHIONINE; NERVE PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; UBIQUITIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL ANALYSIS; CONTROLLED STUDY; COVALENT BOND; ENZYME INHIBITION; INTERPHASE; MITOSIS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RESIDUE ANALYSIS; UBIQUITINATION; XENOPUS LAEVIS; ACETYLATION; ANIMAL; ANIMAL EMBRYO; CYTOLOGY; ENZYME SPECIFICITY; FEMALE; METABOLISM; OOCYTE; PHYSIOLOGY; XENOPUS;

ANURA; XENOPUS LAEVIS;

ACETYLATION; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; EMBRYO, NONMAMMALIAN; FEMALE; LYSINE; METHIONINE; MITOSIS; NERVE TISSUE PROTEINS; OVUM; SUBSTRATE SPECIFICITY; UBIQUITIN; XENOPUS;

EID: 67650106548     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809366200     Document Type: Article

References (30)

1. Glickman, M. H., and Ciechanover, A. (2002) Physiol. Rev. 82, 373-428
2. Ciechanover, A., and Ben-Saadon, R. (2004) Trends Cell Biol. 14, 103-106
3. Cadwell, K., and Coscoy, L. (2005) Science 309, 127-130
4. Breitschopf, K., Bengal, E., Ziv, T., Admon, A., and Ciechanover, A. (1998) EMBO J. 17, 5964-5973
5. Carvalho, A. F., Pinto, M. P., Grou, C. P., Alencastre, I. S., Fransen, M., Sá-Miranda, C., and Azevedo, J. E. (2007) J. Biol. Chem. 282, 31267-31272
6. Williams, C., van den Berg, M., Sprenger, R. R., and Distel, B. (2007) J. Biol. Chem. 282, 22534-22543
7. Ravid, T., and Hochstrasser, M. (2007) Nat Cell Biol. 9, 422-427
8. Tait, S. W., de Vries, E., Maas, C., Keller, A. M., D'Santos, C. S., and Borst, J. (2007) J. Cell Biol. 179, 1453-1466
9. Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M. Z., Zubiaga, A., Hua, X., Fan, G., and Greenberg, M. E. (2001) Cell 104, 365-376
10. Salic, A., Lee, E., Mayer, L., and Kirschner, M. W. (2000) Mol. Cell 5, 523-532
11. Vosper, J. M., Fiore-Heriche, C. S., Horan, I., Wilson, K., Wise, H., and Philpott, A. (2007) Biochem. J. 407, 277-284
12. Butt, T. R., Khan, M. I., Marsh, J., Ecker, D. J., and Crooke, S. T. (1988) J. Biol. Chem. 263, 16364-16371
13. Raiborg, C., Bache, K. G., Gillooly, D. J., Madshus, I. H., Stang, E., and Stenmark, H. (2002) Nat. Cell Biol. 4, 394-398
14. Rubenstein, P., Smith, P., Deuchler, J., and Redman, K. (1981) J. Biol. Chem. 256, 8149-8155
15. Palmiter, R. D. (1977) J. Biol. Chem. 252, 8781-8783
16. Chau, V., Tobias, J. W., Bachmair, A-, Marriott, D., Ecker, D. J., Gonda, D. K., and Varshavsky, A. (1989) Science 243, 1576-1583
17. Ciechanover, A. (2005) in Ubiquitin-Proteasome Protocols (Patterson, C., and Cyr, D. M., eds) pp. 255-270, Humana Press, New York
18. Polevoda, B., and Sherman, F. (2003) J. Mol. Biol. 325, 595-622
19. Kuo, M. L., den Besten, W., Bertwistle, D., Roussel, M. F., and Sherr, C. J. (2004) Genes-Dev. 18, 1862-1874
20. Meinnel, T., Peynot, P., and Giglione, C. (2005) Biochimie 87,701-712
21. Hershko, A., Ganoth, D., Pehrson, J., Palazzo, R. E., and Cohen, L.-H. (1991) J. Biol. Chem. 266, 16376-16379
22. Lindon, C., Albagli, O., Domeyne, P., Montarras, D., and Pinset, C. (2000) Mol. Cell. Biol. 20, 8923-8932
23. Murray, A. W., and Kirschner, M. W. (1989) Nature 339, 275-280
24. Passmore, L. A., and Barford, D. (2004) Biochem. J. 379, 513-525
25. Lingbeck, J. M., Trausch-Azar, J. S., Ciechanover, A., and Schwartz, A.L. (2003) J. Biol. Chem. 278, 1817-1823
26. Hoyt, M. A., and Coffino, P. (2004) Cell Mol Life Sci. 61, 1596-1600
27. Sadeh, R., Breitschopf, K., Bercovich, B., Zoabi, M., Kravtsova-Ivantsiv, Y., Kornitzer, D., Schwartz, A., and Ciechanover, A. (2008) Proc. Natl Acad. Sci. U. S. A. 105, 15690-15695
28. Tintignac, L. A., Lagirand, J., Batonnet, S., Sirri, V., Leibovitch, M. P., and Leibovitch, S. A. (2005) J. Biol. Chem. 280, 2847-2856
29. Rodway, H., Llanos, S., Rowe, J., and Peters, G. (2004) Oncogene 23, 6186-6192
30. Pollice, A., Vivo, M., and La Mantia, G. (2008) FEBS Lett 582, 3257-3262