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Volumn 297, Issue 1, 2009, Pages

Endofacial competitive inhibition of the glucose transporter 1 activity by gossypol

Author keywords

Glucose transport; GLUT1 transporter; Transporter inhibition

Indexed keywords

CYTOCHALASIN B; GLUCOSE TRANSPORTER 1; GOSSYPOL;

EID: 67650083307     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00501.2008     Document Type: Article
Times cited : (25)

References (59)
  • 1
    • 0036685357 scopus 로고    scopus 로고
    • Interactions of ATP, oestradiol, genistein and the anti-oestrogens, faslodex (ICI 182780) and tamoxifen, with the human erythrocyte glucose transporter, GLUT1
    • Afzal I, Cunningham P, Naftalin RJ. Interactions of ATP, oestradiol, genistein and the anti-oestrogens, faslodex (ICI 182780) and tamoxifen, with the human erythrocyte glucose transporter, GLUT1. Biochem J 365: 707-719, 2002.
    • (2002) Biochem J , vol.365 , pp. 707-719
    • Afzal, I.1    Cunningham, P.2    Naftalin, R.J.3
  • 2
    • 0018199174 scopus 로고
    • Asymmetry of the hexose transfer system in human erythrocytes. Comparison of the effects of cytochalasin B, phloretin and maltose as competitive inhibitors
    • Basketter DA, Widdas WF. Asymmetry of the hexose transfer system in human erythrocytes. Comparison of the effects of cytochalasin B, phloretin and maltose as competitive inhibitors. J Physiol 278: 389-401, 1978.
    • (1978) J Physiol , vol.278 , pp. 389-401
    • Basketter, D.A.1    Widdas, W.F.2
  • 5
    • 0010980331 scopus 로고
    • Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein
    • Birnbaum MJ, Haspel HC, Rosen OM. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc Natl Acad Sci USA 83: 5784-5788, 1986.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 5784-5788
    • Birnbaum, M.J.1    Haspel, H.C.2    Rosen, O.M.3
  • 7
    • 0022979710 scopus 로고
    • ATP regulation of the human red cell sugar transporter
    • Carruthers A. ATP regulation of the human red cell sugar transporter. J Biol Chem 261: 11028-11037, 1986.
    • (1986) J Biol Chem , vol.261 , pp. 11028-11037
    • Carruthers, A.1
  • 8
    • 0025036574 scopus 로고
    • Facilitated diffusion of glucose
    • Carruthers A. Facilitated diffusion of glucose. Physiol Rev 70: 1135-1176, 1990.
    • (1990) Physiol Rev , vol.70 , pp. 1135-1176
    • Carruthers, A.1
  • 9
    • 0029845798 scopus 로고    scopus 로고
    • Human erythrocyte sugar transport is incompatible with available carrier models
    • Cloherty EK, Heard KS, Carruthers A. Human erythrocyte sugar transport is incompatible with available carrier models. Biochemistry 35: 10411-10421, 1996.
    • (1996) Biochemistry , vol.35 , pp. 10411-10421
    • Cloherty, E.K.1    Heard, K.S.2    Carruthers, A.3
  • 10
    • 0022442571 scopus 로고
    • Membrane structural/functional perturbations induced by gossypol. Effects on membrane order, liposome permeability, and insulin-sensitive hexose transport
    • De Peyster A, Hyslop PA, Kuhn CE, Sauerheber RD. Membrane structural/functional perturbations induced by gossypol. Effects on membrane order, liposome permeability, and insulin-sensitive hexose transport. Biochem Pharmacol 35: 3293-3300, 1986.
    • (1986) Biochem Pharmacol , vol.35 , pp. 3293-3300
    • De Peyster, A.1    Hyslop, P.A.2    Kuhn, C.E.3    Sauerheber, R.D.4
  • 11
    • 0017829107 scopus 로고
    • Cytochalasin B and the kinetics of inhibition of biological transport: A case of asymmetric binding to the glucose carrier
    • Deves R, Krupka RM. Cytochalasin B and the kinetics of inhibition of biological transport: a case of asymmetric binding to the glucose carrier. Biochim Biophys Acta 510: 339-348, 1978.
    • (1978) Biochim Biophys Acta , vol.510 , pp. 339-348
    • Deves, R.1    Krupka, R.M.2
  • 13
    • 0029031013 scopus 로고
    • Antiproliferative activity of gossypol and gossypolone on human breast cancer cells
    • Gilbert NE, O'Reilly JE, Chang CJ, Lin YC, Brueggemeier RW. Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. Life Sci 57: 61-67, 1995.
    • (1995) Life Sci , vol.57 , pp. 61-67
    • Gilbert, N.E.1    O'Reilly, J.E.2    Chang, C.J.3    Lin, Y.C.4    Brueggemeier, R.W.5
  • 15
    • 0020481573 scopus 로고
    • Changes in the intrinsic fluorescence of the human erythrocyte monosaccharide transporter upon ligand binding
    • Gorga FR, Lienhard GE. Changes in the intrinsic fluorescence of the human erythrocyte monosaccharide transporter upon ligand binding. Biochemistry 21: 1905-1908, 1982.
    • (1982) Biochemistry , vol.21 , pp. 1905-1908
    • Gorga, F.R.1    Lienhard, G.E.2
  • 16
    • 0025309006 scopus 로고
    • Inhibitory effect of gossypol on steroidogenic pathways in cultured bovine luteal cells
    • Gu Y, Lin YC, Rikihisa Y. Inhibitory effect of gossypol on steroidogenic pathways in cultured bovine luteal cells. Biochem Biophys Res Commun 169: 455-461, 1990.
    • (1990) Biochem Biophys Res Commun , vol.169 , pp. 455-461
    • Gu, Y.1    Lin, Y.C.2    Rikihisa, Y.3
  • 17
    • 0021967494 scopus 로고
    • Effect of gossypol on erythrocyte membrane function: Specific inhibition of inorganic anion exchange and interaction with band 3
    • Haspel HC, Corin RE, Sonenberg M. Effect of gossypol on erythrocyte membrane function: specific inhibition of inorganic anion exchange and interaction with band 3. J Pharmacol Exp Ther 234: 575-583, 1985.
    • (1985) J Pharmacol Exp Ther , vol.234 , pp. 575-583
    • Haspel, H.C.1    Corin, R.E.2    Sonenberg, M.3
  • 18
    • 0034696679 scopus 로고    scopus 로고
    • ATP-dependent substrate occlusion by the human erythrocyte sugar transporter
    • Heard KS, Fidyk N, Carruthers A. ATP-dependent substrate occlusion by the human erythrocyte sugar transporter. Biochemistry 39: 3005-3014, 2000.
    • (2000) Biochemistry , vol.39 , pp. 3005-3014
    • Heard, K.S.1    Fidyk, N.2    Carruthers, A.3
  • 19
    • 0028906339 scopus 로고
    • Barbiturates inhibit hexose transport in cultured mammalian cells and human erythrocytes and interact directly with purified GLUT-1
    • Honkanen R, McBath H, Kushmerick C, Callender G, Scarlata S, Fenstermacher J, Haspel H. Barbiturates inhibit hexose transport in cultured mammalian cells and human erythrocytes and interact directly with purified GLUT-1. Biochemistry 34: 535-544, 1995.
    • (1995) Biochemistry , vol.34 , pp. 535-544
    • Honkanen, R.1    McBath, H.2    Kushmerick, C.3    Callender, G.4    Scarlata, S.5    Fenstermacher, J.6    Haspel, H.7
  • 20
    • 0035685698 scopus 로고    scopus 로고
    • The extended GLUT-family of sugar/polyol transport facilitators: Nomenclature, sequence characteristics, and potential function of its novel members
    • Joost HG, Thorens B. The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members. Mol Membr Biol 18: 247-256, 2001.
    • (2001) Mol Membr Biol , vol.18 , pp. 247-256
    • Joost, H.G.1    Thorens, B.2
  • 21
    • 0017688926 scopus 로고
    • Reconstitution and purification of the D-glucose transporter from human erythrocytes
    • Kasahara M, Hinkle PC. Reconstitution and purification of the D-glucose transporter from human erythrocytes. J Biol Chem 252: 7384-7390, 1977.
    • (1977) J Biol Chem , vol.252 , pp. 7384-7390
    • Kasahara, M.1    Hinkle, P.C.2
  • 22
    • 0021013901 scopus 로고
    • The regulation of glucose transport by cAMP stimulators via three different mechanisms in rat and human adipocytes
    • Kashiwagi A, Huecksteadt TP, Foley JE. The regulation of glucose transport by cAMP stimulators via three different mechanisms in rat and human adipocytes. J Biol Chem 258: 13685-13692, 1983.
    • (1983) J Biol Chem , vol.258 , pp. 13685-13692
    • Kashiwagi, A.1    Huecksteadt, T.P.2    Foley, J.E.3
  • 23
    • 1442286330 scopus 로고    scopus 로고
    • The role of Bcl-2 family members in tumorigenesis
    • Kirkin V, Joos S, Zornig M. The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta 1644: 229-249, 2004.
    • (2004) Biochim Biophys Acta , vol.1644 , pp. 229-249
    • Kirkin, V.1    Joos, S.2    Zornig, M.3
  • 24
    • 0141569444 scopus 로고    scopus 로고
    • Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
    • Kitada S, Leone M, Sareth S, Zhai D, Reed J, Pellecchia M. Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem 46: 4259-4264, 2003.
    • (2003) J Med Chem , vol.46 , pp. 4259-4264
    • Kitada, S.1    Leone, M.2    Sareth, S.3    Zhai, D.4    Reed, J.5    Pellecchia, M.6
  • 25
    • 0016828514 scopus 로고
    • Interaction of steroids with the transport system of glucose in human erythrocytes
    • Lacko L, Wittke B, Geck P. Interaction of steroids with the transport system of glucose in human erythrocytes. J Cell Physiol 86, Suppl 2: 673-680, 1975.
    • (1975) J Cell Physiol , vol.86 , Issue.SUPPL. 2 , pp. 673-680
    • Lacko, L.1    Wittke, B.2    Geck, P.3
  • 26
    • 0019391534 scopus 로고
    • Interaction of benzoic acid derivatives with the transport system of glucose in human erythrocytes
    • Lacko L, Wittke B, Zimmer G. Interaction of benzoic acid derivatives with the transport system of glucose in human erythrocytes. Biochem Pharmacol 30: 1425-1431, 1981.
    • (1981) Biochem Pharmacol , vol.30 , pp. 1425-1431
    • Lacko, L.1    Wittke, B.2    Zimmer, G.3
  • 27
    • 0023665198 scopus 로고
    • Evidence that forskolin binds to the glucose transporter of human erythrocytes
    • Lavis VR, Lee DP, Shenolikar S. Evidence that forskolin binds to the glucose transporter of human erythrocytes. J Biol Chem 262: 14571-14575, 1987.
    • (1987) J Biol Chem , vol.262 , pp. 14571-14575
    • Lavis, V.R.1    Lee, D.P.2    Shenolikar, S.3
  • 28
    • 0036450381 scopus 로고    scopus 로고
    • An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines
    • Le Blanc M, Russo J, Kudelka AP, Smith JA. An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines. Pharmacol Res 46: 551-555, 2002.
    • (2002) Pharmacol Res , vol.46 , pp. 551-555
    • Le Blanc, M.1    Russo, J.2    Kudelka, A.P.3    Smith, J.A.4
  • 29
    • 0001100135 scopus 로고
    • The attachment of phloretin and analogues to human erythrocytes in connection with inhibition of sugar transport
    • LeFevre PG, Marshall JK. The attachment of phloretin and analogues to human erythrocytes in connection with inhibition of sugar transport. J Biol Chem 234: 3022-3026, 1959.
    • (1959) J Biol Chem , vol.234 , pp. 3022-3026
    • LeFevre, P.G.1    Marshall, J.K.2
  • 31
    • 17144366551 scopus 로고    scopus 로고
    • Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol 1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase
    • Mayr GW, Windhorst S, Hillemeier K. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrate inositol 1,4,5-trisphosphate 3-kinases and inositol polyphosphate multikinase. J Biol Chem 280: 13229-13240, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 13229-13240
    • Mayr, G.W.1    Windhorst, S.2    Hillemeier, K.3
  • 33
    • 13944252626 scopus 로고    scopus 로고
    • Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL [(-)-gossypol] against diffuse large cell lymphoma
    • Mohammad RM, Wang S, Aboukameel A, Chen B, Wu X, Chen J, Al-Katib A. Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL [(-)-gossypol] against diffuse large cell lymphoma. Mol Cancer Ther 4: 13-21, 2005.
    • (2005) Mol Cancer Ther , vol.4 , pp. 13-21
    • Mohammad, R.M.1    Wang, S.2    Aboukameel, A.3    Chen, B.4    Wu, X.5    Chen, J.6    Al-Katib, A.7
  • 35
    • 57649114095 scopus 로고    scopus 로고
    • Alternating carrier models of asymmetric glucose transport violate the energy conservation laws
    • Naftalin R. Alternating carrier models of asymmetric glucose transport violate the energy conservation laws. Biophys J 95: 4300-4314, 2008.
    • (2008) Biophys J , vol.95 , pp. 4300-4314
    • Naftalin, R.1
  • 36
    • 0024260126 scopus 로고
    • Metabolism of round spermatids in the rat: Effect of gossypol on the glucose transport
    • Nakamura M, Ikeda M, Okinaga S, Arai K. Metabolism of round spermatids in the rat: effect of gossypol on the glucose transport. Andrologia 20: 411-416, 1988.
    • (1988) Andrologia , vol.20 , pp. 411-416
    • Nakamura, M.1    Ikeda, M.2    Okinaga, S.3    Arai, K.4
  • 37
    • 0025186843 scopus 로고
    • Ligand-dependent quenching of tryptophan fluorescence in human erythrocyte hexose transport protein
    • Pawagi AB, Deber CM. Ligand-dependent quenching of tryptophan fluorescence in human erythrocyte hexose transport protein. Biochemistry 29: 950-955, 1990.
    • (1990) Biochemistry , vol.29 , pp. 950-955
    • Pawagi, A.B.1    Deber, C.M.2
  • 38
    • 0018863796 scopus 로고
    • Gossypol, a powerful inhibitor of human spermatozoal metabolism
    • Poso H, Wichmann K, Janne J, Luukkainen T. Gossypol, a powerful inhibitor of human spermatozoal metabolism. Lancet 1: 885-886, 1980.
    • (1980) Lancet , vol.1 , pp. 885-886
    • Poso, H.1    Wichmann, K.2    Janne, J.3    Luukkainen, T.4
  • 39
    • 0029558583 scopus 로고
    • Bcl-2 family proteins: Regulators of chemoresistance in cancer
    • Reed J. Bcl-2 family proteins: regulators of chemoresistance in cancer. Toxicol Lett 82-83: 155-158, 1995.
    • (1995) Toxicol Lett , vol.82-83 , pp. 155-158
    • Reed, J.1
  • 40
    • 0028972616 scopus 로고
    • Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance
    • Reed J. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol 7: 541-546, 1995.
    • (1995) Curr Opin Oncol , vol.7 , pp. 541-546
    • Reed, J.1
  • 45
    • 12344321851 scopus 로고    scopus 로고
    • Predicting the three-dimensional structure of the human facilitative glucose transporter GLUT1 by a novel evolutionary homology strategy: Insights on the molecular mechanism of substrate migration, and binding sites for glucose and inhibitory molecules
    • Salas-Burgos A, Iserovich P, Zuniga F, Vera JC, Fischbarg J. Predicting the three-dimensional structure of the human facilitative glucose transporter GLUT1 by a novel evolutionary homology strategy: insights on the molecular mechanism of substrate migration, and binding sites for glucose and inhibitory molecules. Biophys J 87: 2990-2999, 2004.
    • (2004) Biophys J , vol.87 , pp. 2990-2999
    • Salas-Burgos, A.1    Iserovich, P.2    Zuniga, F.3    Vera, J.C.4    Fischbarg, J.5
  • 46
    • 0000504316 scopus 로고
    • Determination of the temperature and pH dependence of glucose transfer across the human erythrocyte membrane measured by glucose exit
    • Sen AK, Widdas WF. Determination of the temperature and pH dependence of glucose transfer across the human erythrocyte membrane measured by glucose exit. J Physiol 160: 392-403, 1962.
    • (1962) J Physiol , vol.160 , pp. 392-403
    • Sen, A.K.1    Widdas, W.F.2
  • 47
    • 0020551667 scopus 로고
    • Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro
    • Stephens DT, Critchlow LM, Hoskins DD. Mechanism of inhibition by gossypol of glycolysis and motility of monkey spermatozoa in vitro. J Reprod Fertil 69: 447-452, 1983.
    • (1983) J Reprod Fertil , vol.69 , pp. 447-452
    • Stephens, D.T.1    Critchlow, L.M.2    Hoskins, D.D.3
  • 48
    • 0034284838 scopus 로고    scopus 로고
    • Inhibition of glucose transport and direct interactions with type 1 facilitative glucose transporter (GLUT-1) by etomidate, ketamine, and propofol: A comparison with barbiturates
    • Stephenson KN, Croxen RL, El Barbary A, Fenstermacher JD, Haspel HC. Inhibition of glucose transport and direct interactions with type 1 facilitative glucose transporter (GLUT-1) by etomidate, ketamine, and propofol: a comparison with barbiturates. Biochem Pharmacol 60: 651-659, 2000.
    • (2000) Biochem Pharmacol , vol.60 , pp. 651-659
    • Stephenson, K.N.1    Croxen, R.L.2    El Barbary, A.3    Fenstermacher, J.D.4    Haspel, H.C.5
  • 52
    • 0028853597 scopus 로고
    • Resolution of the facilitated transport of dehydroascorbic acid from its intracellular accumulation as ascorbic acid
    • Vera JC, Rivas CI, Velasquez FV, Zhang RH, Concha II, Golde DW. Resolution of the facilitated transport of dehydroascorbic acid from its intracellular accumulation as ascorbic acid. J Biol Chem 270: 23706-23712, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 23706-23712
    • Vera, J.C.1    Rivas, C.I.2    Velasquez, F.V.3    Zhang, R.H.4    Concha, I.I.5    Golde, D.W.6
  • 53
    • 0028122226 scopus 로고
    • Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid
    • Vera JC, Rivas CI, Zhang RH, Farber CM, Golde DW. Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood 84: 1628-1634, 1994.
    • (1994) Blood , vol.84 , pp. 1628-1634
    • Vera, J.C.1    Rivas, C.I.2    Zhang, R.H.3    Farber, C.M.4    Golde, D.W.5
  • 54
    • 0024394011 scopus 로고
    • An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease
    • Wu D. An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agent and in gynaecological disease. Drugs 38: 333-341, 1989.
    • (1989) Drugs , vol.38 , pp. 333-341
    • Wu, D.1
  • 55
    • 0024334136 scopus 로고
    • An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma
    • Wu YW, Chik CL, Knazek RA. An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma. Cancer Res 49: 3754-3758, 1989.
    • (1989) Cancer Res , vol.49 , pp. 3754-3758
    • Wu, Y.W.1    Chik, C.L.2    Knazek, R.A.3
  • 56
    • 20044368078 scopus 로고    scopus 로고
    • Xu L, Yang D, Wang S, Tang W, Liu M, Davis M, Chen J, Rae JM, Lawrence T, Lippman ME. (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. Mol Cancer Ther 4: 197-205, 2005.
    • Xu L, Yang D, Wang S, Tang W, Liu M, Davis M, Chen J, Rae JM, Lawrence T, Lippman ME. (-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer. Mol Cancer Ther 4: 197-205, 2005.
  • 57
    • 0030812936 scopus 로고    scopus 로고
    • Gossypol modification of Ala-1 of secreted phospholipase A2: A probe for the kinetic effects of sulfate glycoconjugates
    • Yu BZ, Rogers J, Ranadive G, Baker S, Wilton DC, Apitz-Castro R, Jain MK. Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates. Biochemistry 36: 12400-12411, 1997.
    • (1997) Biochemistry , vol.36 , pp. 12400-12411
    • Yu, B.Z.1    Rogers, J.2    Ranadive, G.3    Baker, S.4    Wilton, D.C.5    Apitz-Castro, R.6    Jain, M.K.7
  • 58
    • 0038682166 scopus 로고    scopus 로고
    • Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells
    • Zhang M, Liu H, Guo R, Ling Y, Wu X, Li B, Roller P, Wang S, Yang D. Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem Pharmacol 66: 93-103, 2003.
    • (2003) Biochem Pharmacol , vol.66 , pp. 93-103
    • Zhang, M.1    Liu, H.2    Guo, R.3    Ling, Y.4    Wu, X.5    Li, B.6    Roller, P.7    Wang, S.8    Yang, D.9
  • 59
    • 0038682166 scopus 로고    scopus 로고
    • Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells
    • Zhang M, Liu H, Guo R, Ling Y, Wu X, Li B, Roller PP, Wang S, Yang D. Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem Pharmacol 66: 93-103, 2003.
    • (2003) Biochem Pharmacol , vol.66 , pp. 93-103
    • Zhang, M.1    Liu, H.2    Guo, R.3    Ling, Y.4    Wu, X.5    Li, B.6    Roller, P.P.7    Wang, S.8    Yang, D.9


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