A new small molecule that directly inhibits the DNA binding of NF-κB

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5293-5297

  Kobayashi, Takanobu ^a   Yoshimori, Atsushi ^b   Kino, Katsuhito ^a   Komori, Rie ^a   Miyazawa, Hiroshi ^a   Tanuma, Sei ich ^c  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

DNA binding; Docking simulation; Fluorescence correlation spectroscopy; Inhibitor; Nuclear factor B

Indexed keywords

4,6 DICHLORO N PHENYL 1,3,5 TRIAZIN 2 AMINE; ASPARTIC ACID; HISTIDINE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NI 241; PROTEIN P50; TRIAZINE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER MODEL; CONCENTRATION RESPONSE; DNA BINDING; DRUG PROTEIN BINDING; DRUG STRUCTURE; FLUORESCENCE CORRELATION SPECTROSCOPY; GEL MOBILITY SHIFT ASSAY; HYDROGEN BOND; MOLECULAR LIBRARY; MOLECULAR MODEL; PROTEIN DNA INTERACTION;

ANILINE COMPOUNDS; ANIMALS; BINDING SITES; COMPUTER SIMULATION; DNA; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 67650075221     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.030     Document Type: Article

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