Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women

Arthritis and Rheumatism

Volumn 60, Issue 7, 2009, Pages 2046-2054

  Valdes, Ana M ^a   Lories, Rik J ^b   Van Meurs, Joyce B ^c   Kerkhof, Hanneke ^c   Doherty, Sally ^d   Hofman, Albert ^c   Hart, Deborah J ^a   Zhang, Feng ^a   Luyten, Frank P ^b   Uitterlinden, Andre G ^c   Doherty, Michael ^d   Spector, Tim D ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN; PROTEIN ANP32A; UNCLASSIFIED DRUG;

ADULT; AGED; ANP32A GENE; ARTICLE; FEMALE; GENE; GENETIC RISK; GENOTYPE; HIP OSTEOARTHRITIS; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT;

AGED; AGED, 80 AND OVER; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GREAT BRITAIN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MIDDLE AGED; NETHERLANDS; OSTEOARTHRITIS, HIP; OSTEOARTHRITIS, KNEE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 67650065023     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24627     Document Type: Article

References (34)

1. Goldring MB. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Pract Res Clin Rheumatol 2006;20:1003-25.
2. Brandt KD, Dieppe P, Radin EL. Etiopathogenesis of osteoarthritis. Rheum Dis Clin North Am 2008;34:531-59.
3. DiCesare PE, Abramson SB. Pathogenesis of osteoarthritis. In: Harris ED Jr, Budd RC, Firestein GS, Genovese MC, Sergent JS, Ruddy S, Sledge CB, editors. Kelley's textbook of rheumatology. 7th ed. Philadelphia: Elsevier/Saunders; 2005. p. 1493-513.
4. Lane NE. Osteoarthritis of the hip. N Engl J Med 2007;357:1413-21.
5. Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Rheum Dis Clin North Am 2008;34:581-603.
6. Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG, et al. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet 2008;82:1231-40.
7. Bai J, Brody JR, Kadkol SS, Pasternack GR. Tumor suppression and potentiation by manipulation of pp32 expression. Oncogene 2001;20:2153-60.
8. Luo W, Lin SC. Axin: a master scaffold for multiple signaling pathways. Neurosignals 2004;13:99-113.
9. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. A human protein-protein interaction network: a resource for annotating the proteome. Cell 2005;122:957-68.
10. Yu LG, Packman LC, Weldon M, Hamlett J, Rhodes JM. Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin. J Biol Chem 2004;279:41377-83.
11. Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM. Regulation of β-catenin signaling by the B56 subunit of protein phosphatase 2A. Science 1999;283:2089-91.
12. Day TF, Guo X, Garrett-Beal L, Yang Y. Wnt/β-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 2005;8:739-50.
13. Akiyama H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, et al. Interactions between Sox9 and β-catenin control chondrocyte differentiation. Genes Dev 2004;18:1072-87.
14. Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, Schrooten J, et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 2007;56:4095-103.
15. Neame RL, Muir K, Doherty S, Doherty M. Genetic risk of knee osteoarthritis: a sibling study. Ann Rheum Dis 2004;63:1022-7.
16. Lanyon P, Muir K, Doherty S, DohertyM. Assessment of a genetic contribution to osteoarthritis of the hip: sibling study. BMJ 2000;321:1179-83.
17. Altman RD, Hochberg MC, Murphy WA, Wolfe F. Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage 1995;3 Suppl A:3-70.
18. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis 1957;16:494-502.
19. Hart DJ, Spector TD. The relationship of obesity, fat distribution and osteoarthritis in the general population: the Chingford Study. J Rheumatol 1993;20:331-5.
20. Hofman A, Breteler MM, van Duijn CM, Krestin GP, Pols HA, Stricker BH, et al. The Rotterdam Study: objectives and design update. Eur J Epidemiol 2007;22:819-29.
21. Reijman M, Hazes JM, Bierma-Zeinstra SM, Koes BW, Christgau S, Christiansen C, et al. A new marker for osteoarthritis: cross-sectional and longitudinal approach. Arthritis Rheum 2004;50:2471-8.
22. Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N, Wilson SG, et al. Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study. Lancet 2008;371:1505-12.
23. Dell'Accio F, De Bari C, Luyten FP. Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo. Arthritis Rheum 2001;44:1608-19.
24. Engels EA, Schmid CH, Terrin N, Olkin I, Lau J. Heterogeneity and statistical significance in meta-analysis: an empirical study of 125 meta-analyses. Stat Med 2000;19:1707-28.
25. Kim HE, Jiang X, Du F, Wang X. PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Mol Cell 2008;30:239-47.
26. Luyten FP, Tylzanowski P, Lories R. Wnt signaling and osteoarthritis. Bone 2008. E-pub ahead of print.
27. Valdes AM, Loughlin J, Oene MV, Chapman K, Surdulescu GL, Doherty M, et al. Sex and ethnic differences in the association of ASPN, CALM1, COL2A1, COMP, and FRZB with genetic susceptibility to osteoarthritis of the knee [published erratum appears in Arthritis Rheum 2009;60:178]. Arthritis Rheum 2007;56:137-46.
28. Valdes AM, Spector TD, Doherty S, Wheeler M, Hart DJ, Doherty M. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Ann Rheum Dis 2008. E-pub ahead of print.
29. Lories RJ, Peeters J, Szlufcik K, Hespel P, Luyten FP. Deletion of frizzled-related protein reduces voluntary running exercise performance in mice. Osteoarthritis Cartilage 2008. E-pub ahead of print.
30. Opal P, Garcia JJ, McCall AE, Xu B, Weeber EJ, Sweatt JD, et al. Generation and characterization of LANP/pp32 null mice. Mol Cell Biol 2004;24:3140-9.
31. Andrew T, Hart DJ, Snieder H, de Lange M, Spector TD, MacGregor AJ. Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res 2001;4:464-77.
32. Ganz R, Leunig M, Leunig-Ganz K, Harris WH. The etiology of osteoarthritis of the hip: an integrated mechanical concept. Clin Orthop Relat Res 2008;466:264-72.
33. Doherty M, Courtney P, Doherty S, Jenkins W, Maciewicz RA, Muir K, et al. Nonspherical femoral head shape (pistol grip deformity), neck shaft angle, and risk of hip osteoarthritis: a case-control study. Arthritis Rheum 2008;58:3172-82.
34. Franklin J, Ingvarsson T, Englund M, Lohmander LS. Sex differences in the association between body mass index and total hip or knee joint replacement due to osteoarthritis. Ann Rheum Dis 2008. E-pub ahead of print.