Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis

Circulation

Volumn 102, Issue 15, 2000, Pages 1744-1747

  Guzik, Tomasz J ^a   West, Nick E J ^a   Black, Edward ^a   McDonald, Denise ^a   Ratnatunga, Chandi ^a   Pillai, Ravi ^a   Channon, Keith M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Atherosclerosis; Endothelium; Genetics; Superoxide

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ADULT; AGED; ALLELE; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAPHENOUS VEIN;

EID: 0034633838     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.15.1744     Document Type: Article

References (11)

1. Interactions between NO and reactive oxygen species: Pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure
2. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: Evidence for involvement of the renin- angiotensin system
3. Vascular superoxide production by NAD(P)H oxidase: Association with endothelial dysfunction and clinical risk factors
4. NAD(P)H oxidase: Role in cardiovascular biology and disease
5. Expression of NADH/NADPH oxidase p22phox in human coronary arteries
6. Polymorphism of the NADH/NADPH oxidase p22phox gene in patients with coronary artery disease
7. A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis
8. C242T polymorphism of NADPH oxidase p22phox gene and ischemic cerebrovascular disease in the Japanese population
9. The p22 phox A640G gene polymorphism but not the C242T gene variation is associated with coronary heart disease in younger individuals
10. How could a genetic variant of the p22(phox) component of NAD(P)H oxidases contribute to the progression of coronary atherosclerosis?
11. Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function