The p22 phox A640G gene polymorphism but not the C242T gene variation is associated with coronary heart disease in younger individuals

Atherosclerosis

Volumn 145, Issue 2, 1999, Pages 315-323

  Gardemann, Andreas ^a   Mages, Petra ^a   Katz, Norbert ^a   Tillmanns, Harald ^a   Haberbosch, Werner ^b  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

^b KERCKHOFF HEART CENTER   (Germany)

Author keywords

Coronary heart disease; Coronary risk factors; Free radicals; Gensini score; Myocardial infarction; Oxidative stress

Indexed keywords

ADENINE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN RECEPTOR; ANGIOTENSINOGEN; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; ARYLDIALKYLPHOSPHATASE; CARRIER PROTEIN; CYBA PROTEIN, HUMAN; CYTOSINE; ESTERASE; GUANINE; LIPOPROTEIN A; PHOSPHOPROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THYMIDINE;

ANGIOCARDIOGRAPHY; ARTICLE; BLOOD; COMPARATIVE STUDY; CORONARY ARTERY DISEASE; GENE DELETION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; HUMAN; MALE; MIDDLE AGED; RADIOGRAPHY; RISK FACTOR; ADULT; AGED; CAUCASIAN; CONTROLLED STUDY; DNA POLYMORPHISM; GENE FREQUENCY; GENOTYPE; HEART INFARCTION; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADENINE; ANGIOTENSINOGEN; APOLIPOPROTEIN A-I; APOLIPOPROTEINS B; ARYLDIALKYLPHOSPHATASE; CORONARY ANGIOGRAPHY; CORONARY DISEASE; CYTOSINE; ESTERASES; GENE DELETION; GUANINE; HUMANS; LIPOPROTEIN(A); MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NADPH DEHYDROGENASE; NADPH OXIDASE; PHOSPHOPROTEINS; POLYMORPHISM, GENETIC; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; RISK FACTORS; THYMIDINE; VARIATION (GENETICS);

EID: 0032588543     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00083-0     Document Type: Article

References (26)

1. Preedy VR, Reilly ME, Mantle D, Peters TJ. Oxidative damage in liver disease. J Int Fed Clin Chem 1998;10:16-20.
2. Alexander RW. Hypertension and the pathogenesis of atherosclerosis: oxidative stress and the mediation of arterial inflammation response: a new perspective. Hypertension 1995;25:155-61.
3. Gritendling KK, Minnert CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 1994;74:1141-8.
4. Mohazzab H KM, Kanmski PM, Wohn MS. NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am J Physiol 1994;266:H2568-78.
5. Ushio-Fukai M, Zatari AM, Fukan T, Ishizaka N, Griendling KK. p22 phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 1996;271:23317-21.
6. Inoue N, Kawashima S, Kanazawa K, Yamada S, Akita H, Yokoyama M. Polymorphism of the NADH/NADPH oxidase p22 phox gene in patients with coronary artery disease. Circulation 1998;97:135-7.
7. Gardemann A, Nguyen QD, Humme J, Stricker J, Katz N, Tillmanns H, Hehrlein FW, Rau M, Haberbosch W. Angiotensin II type 1 receptor A1166C gene polymorphism: Absence of an association to the risk of coronary artery disease and myocardial infarction and of a synergistic effect with the angiotensin-converting enzyme gene polymorphism on the risk of these diseases. Eur Heart J 1998;19:1657-65.
8. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol 1983;51:606.
9. Gardemann A, Schwartz O, Haberbosch W, Katz N, Weiß T, Tillmanns G, Hehrlein FW, Waas W, Eberbach A Positive association of the β fibrinogen H1/H2 gene variation to basal fibrinogen levels and to the increase in fibrinogen concentration during acute phase reaction but not to coronary artery disease and myocardial infarction, Thromb Haemost 1997;77:1120-6.
10. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990;86:1343-6.
11. Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer M, Grodstein F, La Motte F, Buring J, Hennekens CH. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 1995;332:706-11.
12. Hegele RA, Brunt H, Connelly PW. A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate. Circulation 1994;90:2207-12.
13. Russ AP, Maerz W, Ruzicka V, Stein U, Gross W. Rapid detection of the hypertension-associated Met235→Thr allele of the human angiotensinogen gene. Hum Mol Genet 1993;2:609-10.
14. Hingorani AD, Brown MJ. A simple molecular assay for the C1166 variant of the angiotensin II type 1 receptor gene. Biochem Biophys Res Commun 1995;213:725-9.
15. Blatter Garin M-C, James RW, Dussoix P, Blanche H, Passa P, Froguel P, Ruiz J. Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. J Clin Invest 1997;99:62-6.
16. Ruiz J, Blanche' H, James RW, Blatter MC, Charpentier G, Morabia A, Passa P, Froguel P. The polymorphism (Gln-Arg192) of the high-density lipoprotein-bound enzyme is an independent cardiovascular risk factor in non-insulin dependent diabetic patients. Lancet 1995;346:869-72.
17. Gardemann A, Weiß T, Schwartz O, Katz N, Eberbach A, Hehrlein FW, Tillmanns G, Waas W, Haberbosch W. Gene polymorphism but not catalytic activity of angiotensin I-converting enzyme is associated to coronary artery disease and myocardial infarction in low risk patients. Circulation 1995;92:2796-9.
18. Gardemann A, Fink M, Stricker J, Nguyen Q, Humme J, Katz N, Tillmanns H, Hehrlein FW, Rau M, Haberbosch W. ACE I/D gene polymorphism: Presence of the ACE D allele increases the risk of coronary artery disease in younger individuals. Atherosclerosis 1998;139:153-9.
19. A1/A2 gene polymorphism to coronary artery disease but not to nonfatal myocardial infarction in low risk patients. Thromb Haemost 1998;80:214-7.
20. Gardemann A, Weidemann H, Philipp M, Katz N, Tillmanns H, Hehrlein FW, Haberbosch W. The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in high risk patients. Eur Heart J, 1999;20:584-92.
21. Unkelbach U, Gardemann A, Kostrzewa M, Philipp M, Tillmanns H, Haberbosch W. A new promotor polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile. Arterioscler, Thromb Vasc Biol 1999;19:932-8.
22. Gardemann A, Ohly D, Fink M, Katz N, Tillmanns H, Hehrlein FW, Haberbosch W. Association of an insertion/deletion polymorphism of the apolipoprotein B gene to the risk of myocardial infarction. Atherosclerosis 1998;141:167-175.
23. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms, oxidation, inflammation, and genetics. Circulation 1995;91:2488-96.
24. Fuster V. Mechanisms leading to myocardial infarction: Insights from studies of vascular biology. Circulation 1994;90:2126-46.
25. Libby P. Molecular bases of the acute coronary syndromes. Circulation 1995;91:2844-50.
26. Fuster V, Badimon L, Badimon J, Cheesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. New Engl J Med 1992;326:242-50.