Triglyceride modulation by acifran analogs: Activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74

Biochemical and Biophysical Research Communications

Volumn 340, Issue 2, 2006, Pages 482-490

  Mahboubi, Keyvan ^a   Witman Jones, Terri ^a,b   Adamus, Jean E ^a   Letsinger, Jack T ^a   Whitehouse, Darren ^a   Moorman, Allan R ^a,c   Sawicki, Diane ^a   Bergenhem, Nils ^a,d   Ross, Stuart A ^a  

^a The Institute for Diabetes Discovery   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c King Pharmaceuticals   (United States)

^d AdipoGenix   (United States)

Author keywords

Acifran analogs; Niacin receptors; Triglycerides

Indexed keywords

ACIFRAN; G PROTEIN COUPLED RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINIC ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PREVALENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; ANTILIPEMIC AGENTS; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FURANS; HUMANS; LIPID METABOLISM; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR SEQUENCE DATA; NIACIN; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; TRIGLYCERIDES;

ANIMALIA;

EID: 29644441229     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.022     Document Type: Article

References (24)

1. R. Altschul, A. Hoffer, and J.D. Stephen Influence of nicotinic acid on serum cholesterol in man Arch. Biochem. Biophys. 54 1955 558 559
2. A. Garg, and S.M. Grundy Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus JAMA 264 1990 723 726
3. A. Garg Lipid-lowering therapy and macrovscular disease in diabetes mellitus Diabetes S2 1992 111 115
4. W.J. Mack, R.H. Selzer, H.N. Hodis, J.K. Erickson, C.R. Liu, C.H. Liu, D.W. Crawford, and D.H. Blankenhorn One-year reduction and longitudinal analysis of carotid intima-media thickness associated with colestipol/niacin therapy Stroke 24 1993 1779 1783
5. E.A. Nikkila, P. Viikinkoski, M. Valle, and M.H. Frick Prevention of progression of coronary atherosclerosis by treatment of hyperlipidemia: a seven year prospective angiographic study Br. Med. J. 289 1984 220 223
6. P.L. Canner, K.G. Berge, N.K. Wenger, J. Stamler, L. Friedman, R.J. Prineas, and W. Friedewald Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin J. Am. Coll. Cardiol. 8 1986 1245 1255
7. L.B. Pritzker Do lipid lowering drugs reduce the risk of coronary heart disease? Crit. Rev. Clin. Lab. Sci. 35 1998 603 621
8. L.A. Carlson, and E.R. Nye Acute effects of nicotinic acid on the plasma free fatty acids. Demonstration of a metabolic type of sympathicolysis Acta. Med. Scand. 179 1966 453 461
9. E.J. Pinter, and C.J. Pattee Biphasic nature of blood glucose and free fatty acid changes following intravenous nicotinic acid in man J. Clin. Endocrinol. Metab. 27 1967 440 443
10. A. Lorenzen, C. Stannek, H. Lang, V. Adrianov, I. Kalvinsh, and U. Schwabe Characterization of a G protein-coupled receptor for nicotinic acid Mol. Pharmacol. 59 2001 349 357
11. A. Wise, S.M. Foord, N.J. Fraser, A.A. Barnes, N. Elshourbagy, M. Eilert, D.M. Ignar, P.R. Murdock, K. Steplewski, A. Green, A.J. Brown, S.J. Dowell, P.G. Szekeres, D.G. Hassall, F.H. Marshall, S. Wilson, and N.B. Pike Molecular identification of high and low affinity receptors for nicotinic acid J. Biol. Chem. 278 2003 9869 9874
12. S. Tunuaru, J. Kero, A. Schaub, C. Wufka, A. Blaukat, K. Pfeffer, and S. Ofermanns PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect Nat. Med. 9 2003 352 355
13. T. Soga, M. Kamohara, J. Takasaki, S. Matsumoto, T. Saito, T. Ohishi, H. Hiyama, A. Matsuo, H. Matsushime, and K. Furuichi Molecular identifcation of nicotinic acid receptor Biochem. Biophys. Res. Commun. 303 2003 364 369
14. A.K.P. Taggart, J. Kero, X. Gan, T.-Q. Cai, K. Cheung, M. Ippolito, N. Ren, R. Kaplan, K. Wu, T.-J. Wu, L. Jin, C. Liaw, R. Chen, J. Richman, D. Connolly, S. Offermanns, S.D. Wright, and M.G. Waters (D)-β-Hyrdoxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G J. Biol. Chem. 280 2005 26649 26652
15. B. Senior, and L. Loridan Direct regulatory effect of ketones on lipolysis and on glucose concentrations in man Nature 219 1968 83 84
16. F.-Y. Jin, V.S. Kamanna, and M.L. Kashyap Niacin accelerates intracellular ApoB degradation by inhibiting triacylglycerol synthesis in human hepatoblastoma (HepG2) cells Arterioscler. Thromb. Vasc. Biol. 19 1999 1051 1059
17. D.B. Hunninghake, K.D. Edwards, G.S. Sopko, and R. Tosiello Controlled trial of acifran in type II hyperlipoproteinemia Clin. Pharmacol. Ther. 38 1985 313 317
18. J.C. LaRosa, V.T. Miller, K.D. Edwards, M.R. DeBovis, and D.B. Stoy Acifran: a double blind, randomized, placebo-controlled efficacy study in type IIa hyperlipoproteinemic patients Artery 14 1987 338 350
19. T.A. Tobey, C.E. Mondon, I. Zavaroni, and G. Reavan Mechanism of insulin resistance in fructose-fed rats Metabolism 31 1982 608 612
20. I. Inoue, K. Takahashi, S. Katayama, Y. Harada, K. Negishi, A. Itabashi, and J. Ishii Effect of troglitazone (CS-045) and benzafibrate on glucose tolerance, liver glycogen synthase activity and b-oxidation in fructose-fed rats Metabolism 44 1995 1626 1630
21. T.D. Werry, P.M. Sexton, and A. Christopoulos "Ins and outs" of seven-transmembrane receptor signalling to ERK Trends Endocrinol. Metab. 16 2005 26 33
22. I. Jirkovsky, M.N. Cayen, Hypolipidemic derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acids. US 4244958, 11, 1981.
23. I. Jirkovsky, and M.N. Cayen Hypolipidemic 4,5-dihydro-4-oxo-5,5- disubstituted-2-furancarboxylic acids J. Med. Chem. 25 1982 1154 1156
24. K.B. Sharpless, W. Amberg, M. Beller, H. Chen, J. Hartung, Y. Kawanami, D. Lübben, E. Manoury, Y. Ogino, T. Shibata, and T.J.O.C. Ukita New ligands double the scope of the catalytic asymmetric dihydroxylation of olefins J. Org. Chem. 56 1991 4585 4588