3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 23, 2007, Pages 6619-6622

  Skinner, Philip J ^a   Cherrier, Martin C ^a   Webb, Peter J ^a   Sage, Carleton R ^a   Dang, Huong T ^a   Pride, Cameron C ^a   Chen, Ruoping ^a   Tamura, Susan Y ^a   Richman, Jeremy G ^a   Connolly, Daniel T ^a   Semple, Graeme ^a  

^a ARENA PHARMACEUTICALS   (United States)

Author keywords

GPR109a; GPR109b; HDL; HM74; HM74A; Lipolysis; Niacin; PUMA G

Indexed keywords

ACIFRAN; AMINOBENZOIC ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR; NICOTINIC ACID;

ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; SUBSTITUTION REACTION;

ANIMALS; BENZOIC ACIDS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; NIACIN; NICOTINIC ACIDS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35648974737     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.058     Document Type: Article

References (17)

1. Wise A., Foord S.M., Fraser N.J., Barnes A.A., Elshourbagy N., Eilert M., Ignar D.M., Murdock P.R., Steplewski K., Green A., Brown A.J., Dowell S.J., Szekeres P.G., Hassall D.G., Marshall F.H., Wilson S., and Pike N.B. J. Biol. Chem. 278 (2003) 9869
2. Soga T., Kamohara M., Takasaki J.M., Shun-Ichiro S., Tetsu O., Takahide H., Hideki M.A., Matsushime H., and Furuichi K. Biochem. Biophys. Res. Commun. 303 (2003) 364
3. Altschul R., Hoffer R., and Stephen J.D. Arch. Biochem. 54 (1955) 558
4. Tavintharan S., and Kashyap M.L. Curr. Atheroscler. Rep. 3 (2001) 74
5. Carlson L.A. J. Int. Med. 258 (2005) 94
6. Zhang Y., Schmidt R.J., Foxworthy P., Emkey R., Oler J.K., Large T.H., Wang H., Su E.W., Mosior M.K., Eacho P.I., and Cao G. Biochem. Biophys. Res. Commun. 334 (2005) 729
7. Tunaru S., Kero J., Schaub A., Wufka C., Blaukat A., Pfeffer K., and Offermanns S. Nat. Med. 9 (2003) 352
8. Svedmyr N., Harthon L., and Lundholm L. Clin. Pharmacol. Ther. 10 (1969) 559
9. Benyó Z., Gille A., Kero J., Csiky M., Suchánková M.C., Nüsing R., Moers A., Pfeffer K., and Offermanns S. J. Clin. Invest. 115 (2005) 3634
10. Maciejewski-Lenoir D., Richman J.G., Hakak Y., Gaidarov I., Behan D.P., and Connolly D.T. J. Investig. Dermatol. 126 (2006) 2637
11. Benyo Z., Gille A., Bennett C.L., Clausen B.E., and Offermanns S. Mol. Pharmacol. 70 (2006) 1844
12. Jirkovsky I., and Cayen M.N. J. Med. Chem. 25 (1982) 1154
13. Soudijn W., van Wijngaarden I., and IJzerman A.P. Med. Res. Rev. 27 (2007) 417
14. LaRosa J.C., Miller V.T., Edwards K.D., DeBovis M.R., and Stoy D. Artery 14 (1987) 338
15. Semple G., Jung J.-K., Johnson B.R., Duong T., Decaire M., Uy J., Gharbaoui T., Boatman P.D., Sage C.R., Chen R., Richman J.G., Connolly D.T., and Semple G. J. Med. Chem. 50 (2007) 1445
16. Mahboubi K., Witman-Jones T., Adamus J.E., Letsinger J.T., Whitehouse D., Moorman A.R., Sawicki D., Bergenhem N., and Ross S.A. Biochem. Biophys. Res. Commun. 340 (2006) 482
17. Semple G., Skinner P.J., Cherrier M.C., Webb P.J., Sage C.R., Tamura S.Y., Chen R., Richman J.G., and Connolly D.T. J. Med. Chem. 49 (2006) 1227