Development of a selective and potent radioactive ligand for histamine H3 receptors: A compound potentially useful for receptor occupancy studies

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4075-4078

  Mitobe, Yuko ^a   Ito, Sayaka ^a   Mizutani, Takashi ^a   Nagase, Tsuyoshi ^a   Sato, Nagaaki ^a   Tokita, Shigeru ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Histamine H3 receptors; Inverse agonist; Radioligand; Receptor occupancy

Indexed keywords

3 [[1,1,1 H 3]METHYL] 2 [4 [[3 (1 PYRROLIDINYL)PROPYL]OXY]PHENYL] 4 (3H) QUINAZOLINONE; CLOBENPROPIT; GLYCOPROTEIN P; HISTAMINE H3 RECEPTOR; MULTIDRUG RESISTANCE PROTEIN 1; RADIOLIGAND; THIOPERAMIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; RECEPTOR BINDING; RECEPTOR OCCUPANCY; STRUCTURE ACTIVITY RELATION; WILD TYPE;

ANIMALS; BRAIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; KINETICS; LIGANDS; MICE; MODELS, CHEMICAL; P-GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 67649983981     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.025     Document Type: Article

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