메뉴 건너뛰기




Volumn 13, Issue 16, 1999, Pages 2239-2250

The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1

Author keywords

Lamivudine; Pharmacokinetics; Phosphorylation

Indexed keywords

CD4 ANTIGEN; DRUG METABOLITE; LAMIVUDINE; LAMIVUDINE DIPHOSPHATE; LAMIVUDINE MONOPHOSPHATE; PHOSPHATE; UNCLASSIFIED DRUG; ZIDOVUDINE;

EID: 0001024860     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199911120-00006     Document Type: Article
Times cited : (131)

References (47)
  • 1
    • 0007010412 scopus 로고    scopus 로고
    • Antiretroviral therapy for HIV infection in 1998: Updated recommendations of the International AIDS Society-USA Panel
    • 1. Carpenter CCJ, Fischl MA, Hammer SM, et al. Antiretroviral therapy for HIV infection in 1998: updated recommendations of the International AIDS Society-USA Panel. JAMA 1998, 280:78-86.
    • (1998) JAMA , vol.280 , pp. 78-86
    • Carpenter, C.C.J.1    Fischl, M.A.2    Hammer, S.M.3
  • 2
    • 0029028067 scopus 로고
    • Potential mechanism for sustained antiretroviral efficacy of AZT 3TC combination therapy
    • 2. Larder BA, Kemp SD, Harrigan PR. Potential mechanism for sustained antiretroviral efficacy of AZT 3TC combination therapy. Science 1995, 269: 696-699.
    • (1995) Science , vol.269 , pp. 696-699
    • Larder, B.A.1    Kemp, S.D.2    Harrigan, P.R.3
  • 3
    • 0027285372 scopus 로고
    • Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase
    • 3. Tisdale M, Kemp SD, Parry NR, et al. Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3′-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proc Natl Acad Sci USA 1993, 90:5653-5656.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5653-5656
    • Tisdale, M.1    Kemp, S.D.2    Parry, N.R.3
  • 4
    • 0025866982 scopus 로고
    • Anti-human immunodeficiency virus type I activity and in vitro toxicity of 2′-deoxy3′thiacytidine (BCH-189), a novel heterocyclic nucleoside analog
    • 4. Soudeyns H, Yao XJ, Gao Q, et al. Anti-human immunodeficiency virus type I activity and in vitro toxicity of 2′-deoxy3′thiacytidine (BCH-189), a novel heterocyclic nucleoside analog. Antimicrob Agents Chemother 1991, 35:1386-1390.
    • (1991) Antimicrob Agents Chemother , vol.35 , pp. 1386-1390
    • Soudeyns, H.1    Yao, X.J.2    Gao, Q.3
  • 5
    • 0026541703 scopus 로고
    • The separated enantiomers of 2′-deoxy-3′-thiacytidine (BCH-189) both inhibit human immunodeficiency virus replication in vitro
    • 5. Coates JA, Cammack N, Jenkinson HJ, et al. The separated enantiomers of 2′-deoxy-3′-thiacytidine (BCH-189) both inhibit human immunodeficiency virus replication in vitro. Antimicrob Agents Chemother 1992, 36:202-205.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 202-205
    • Coates, J.A.1    Cammack, N.2    Jenkinson, H.J.3
  • 6
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
    • 6. Gulick RM, Mellors JW, Havlir D, et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med 1997, 337:734-739.
    • (1997) N Engl J Med , vol.337 , pp. 734-739
    • Gulick, R.M.1    Mellors, J.W.2    Havlir, D.3
  • 7
    • 0442268112 scopus 로고    scopus 로고
    • A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
    • 7. Hammer S, Squires K, Hughes M, et al. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. N Engl J Med 1997, 337:725-733.
    • (1997) N Engl J Med , vol.337 , pp. 725-733
    • Hammer, S.1    Squires, K.2    Hughes, M.3
  • 10
    • 8544272641 scopus 로고    scopus 로고
    • Efficacy and safety of triple combination therapy with invirase (saquinavir/SQ/HIV protease inhibitor), Epivir (3TC/lamivudine) and Retrovir (ZDV/zidovudine) in HIV-infected patients
    • Vancouver, July [abstract Mo.B172]
    • 10. Baruch A, Mastrodonato-Delora P, Schnipppr E, Salgo M. Efficacy and safety of triple combination therapy with Invirase (saquinavir/SQ/HIV protease inhibitor), Epivir (3TC/lamivudine) and Retrovir (ZDV/zidovudine) in HIV-infected patients. XI Conference on AIDS. Vancouver, July 1996 [abstract Mo.B172].
    • (1996) XI Conference on AIDS
    • Baruch, A.1    Mastrodonato-Delora, P.2    Schnipppr, E.3    Salgo, M.4
  • 11
    • 0013538264 scopus 로고    scopus 로고
    • Triple therapy with AZT and 3TC in combination with nelfinavir mesylate in 12 antiretroviral-naïve subjects chronically infected with HIV-1
    • Vancouver, July [abstract LB.B 6031]
    • 11. Markowitz M, Cao Y, Hurley A, et al. Triple therapy with AZT and 3TC in combination with nelfinavir mesylate in 12 antiretroviral-naïve subjects chronically infected with HIV-1. XI Conference on AIDS. Vancouver, July 1996 [abstract LB.B 6031].
    • (1996) XI Conference on AIDS
    • Markowitz, M.1    Cao, Y.2    Hurley, A.3
  • 12
    • 0003271924 scopus 로고    scopus 로고
    • Efficacy of zidovudine, lamivudine, and ritonavir combination in patients with symptomatic primary HIV-1 infection: The ANRS 053/53B trial. Can eradication be obtained?
    • Chicago, February [abstract 524]
    • 12. Hoen B, Harzic M, Dumon C, et al. Efficacy of zidovudine, lamivudine, and ritonavir combination in patients with symptomatic primary HIV-1 infection: the ANRS 053/53B trial. Can eradication be obtained? Fifth Conference on Retroviruses and Opportunistic Infections. Chicago, February 1998 [abstract 524].
    • (1998) Fifth Conference on Retroviruses and Opportunistic Infections
    • Hoen, B.1    Harzic, M.2    Dumon, C.3
  • 13
    • 0032122438 scopus 로고    scopus 로고
    • Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection
    • 13. Culick RM, Mellors JW, Havlir D, et al. Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection. JAMA 1998, 280:35-41.
    • (1998) JAMA , vol.280 , pp. 35-41
    • Culick, R.M.1    Mellors, J.W.2    Havlir, D.3
  • 14
    • 0029563673 scopus 로고
    • Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter
    • 14. Eron JJ, Benoit SL, Jemsek J, et al. Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter. N Engl J Med 1995, 333:1662-1669.
    • (1995) N Engl J Med , vol.333 , pp. 1662-1669
    • Eron, J.J.1    Benoit, S.L.2    Jemsek, J.3
  • 15
    • 0028783393 scopus 로고
    • Mitochondrial toxicity - New adverse drug effects
    • 15. Swartz MN. Mitochondria! toxicity - new adverse drug effects. N Engl J Med 1995, 333:1146-1148.
    • (1995) N Engl J Med , vol.333 , pp. 1146-1148
    • Swartz, M.N.1
  • 16
    • 0026651622 scopus 로고
    • Effects of (-)-2′deoxy-3′-thiacytidine (3TC) 5′-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases α, β, and γ
    • 16. Hart GJ, Orr DC, Penn CR, et al. Effects of (-)-2′deoxy-3′-thiacytidine (3TC) 5′-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases α, β, and γ. Antimicrob Agents Chemother 1992, 36:1688-1694.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 1688-1694
    • Hart, G.J.1    Orr, D.C.2    Penn, C.R.3
  • 17
    • 0030899204 scopus 로고    scopus 로고
    • Lamivudine: A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection
    • 17. Perry CM, Faulds D. Lamivudine: a review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV infection. Drugs 1997, 53:657-680.
    • (1997) Drugs , vol.53 , pp. 657-680
    • Perry, C.M.1    Faulds, D.2
  • 18
    • 0026740310 scopus 로고
    • Cellular metabolism of (-) enantiomeric 2′-deoxy-3′-thiacytidine
    • 18. Cammack N, Rouse P, Marr CLP, et al. Cellular metabolism of (-) enantiomeric 2′-deoxy-3′-thiacytidine. Biochem Pharmacol 1992, 43:2059-2064.
    • (1992) Biochem Pharmacol , vol.43 , pp. 2059-2064
    • Cammack, N.1    Rouse, P.2    Marr, C.L.P.3
  • 20
    • 0028865886 scopus 로고
    • The intracellular phosphorylation of (-) 2′-deoxy-3′-thiacytidine (3TC) and the incorporation of 3TC 5′-monophosphate into DNA by HIV-1 reverse transcriptase and human DNA polymerase γ
    • 20. Gray NM, Marr CLP, Penn CR, Cameron JM, Bethell RC. The intracellular phosphorylation of (-) 2′-deoxy-3′-thiacytidine (3TC) and the incorporation of 3TC 5′-monophosphate into DNA by HIV-1 reverse transcriptase and human DNA polymerase γ. Biochem Pharmacol 1995, 50:1043-1051.
    • (1995) Biochem Pharmacol , vol.50 , pp. 1043-1051
    • Gray, N.M.1    Marr, C.L.P.2    Penn, C.R.3    Cameron, J.M.4    Bethell, R.C.5
  • 21
    • 84920339885 scopus 로고    scopus 로고
    • Measurements of intracellular lamivudine and zidovudine metabolites in peripheral blood mononuclear cells (PBMCs) from HIV-treated patients
    • Chicago, February [abstract 361]
    • 21. Robbins BL, Tran TT, Pinkerton Jr FH, et al. Measurements of intracellular lamivudine and zidovudine metabolites in peripheral blood mononuclear cells (PBMCs) from HIV-treated patients. Fifth Conference on Retroviruses and Opportunistic Infections. Chicago, February 1998 [abstract 361].
    • (1998) Fifth Conference on Retroviruses and Opportunistic Infections
    • Robbins, B.L.1    Tran, T.T.2    Pinkerton F.H., Jr.3
  • 22
    • 0003265416 scopus 로고    scopus 로고
    • Intracellular phosphorylation of stavudine (d4T) and 3TC correlates with their antiviral activity in naive and zidovudine (ZDV) experienced HIV-infected patients
    • Chicago, February [abstract 362]
    • 22. Sommadossi J-P, Valantin MA, Zhou X-J, et al. Intracellular phosphorylation of stavudine (d4T) and 3TC correlates with their antiviral activity in naive and zidovudine (ZDV) experienced HIV-infected patients. Fifth Conference on Retroviruses and Opportunistic Infections. Chicago, February 1998 [abstract 362].
    • (1998) Fifth Conference on Retroviruses and Opportunistic Infections
    • Sommadossi, J.-P.1    Valantin, M.A.2    Zhou, X.-J.3
  • 23
    • 0027998291 scopus 로고
    • The production and evaluation of a radioligand and antiserum for the radioimmunoassay of subnanogram per millilitre concentrations of lamivudine
    • 23. Wring SA, O'Neill RM, Williams JL, et al. The production and evaluation of a radioligand and antiserum for the radioimmunoassay of subnanogram per millilitre concentrations of lamivudine. J Pharmaceut Biomed Anal 1994, 12:1573-1583.
    • (1994) J Pharmaceut Biomed Anal , vol.12 , pp. 1573-1583
    • Wring, S.A.1    Neill, R.M.2    Williams, J.L.3
  • 25
    • 0015356770 scopus 로고
    • The use of nonparametric methods in the statistical analysis of the two period change-over design
    • 25. Koch GG. The use of nonparametric methods in the statistical analysis of the two period change-over design. Biometrics 1972, 28:577-584.
    • (1972) Biometrics , vol.28 , pp. 577-584
    • Koch, G.G.1
  • 26
    • 0007555726 scopus 로고    scopus 로고
    • Zidovudine (ZDV) phosphorylation determined at intervals over 12 months in naïve and antiretroviral experienced HIV+ patients
    • Chicago, February [abstract LB10]
    • 26. Back DJ, Hoggard PG, Gibbons SE, et al. Zidovudine (ZDV) phosphorylation determined at intervals over 12 months in naïve and antiretroviral experienced HIV+ patients. Fifth Conference on Retroviruses and Opportunistic Infections. Chicago, February 1998 [abstract LB10].
    • (1998) Fifth Conference on Retroviruses and Opportunistic Infections
    • Back, D.J.1    Hoggard, P.G.2    Gibbons, S.E.3
  • 27
    • 0029736999 scopus 로고    scopus 로고
    • A systemic and cellular model for zidovudine plasma concentrations and intracellular phosphorylation in patients
    • 27. Rodman JH, Robbins B, Flynn PM, et al. A systemic and cellular model for zidovudine plasma concentrations and intracellular phosphorylation in patients. J Infect Dis 1996, 174:490-499.
    • (1996) J Infect Dis , vol.174 , pp. 490-499
    • Rodman, J.H.1    Robbins, B.2    Flynn, P.M.3
  • 28
    • 1842301158 scopus 로고    scopus 로고
    • Selective inhibition of syncytium-inducing and nonsyncytium-inducing HIV-1 variants in individuals receiving didanosine or zidovudine, respectively
    • 28. Van't Wout AB, Ran LJ, De Jong MD, et al. Selective inhibition of syncytium-inducing and nonsyncytium-inducing HIV-1 variants in individuals receiving didanosine or zidovudine, respectively. J Clin Invest 1997, 100:2325-2332.
    • (1997) J Clin Invest , vol.100 , pp. 2325-2332
    • Van't Wout, A.B.1    Ran, L.J.2    De Jong, M.D.3
  • 29
    • 0029017994 scopus 로고
    • Drug interactions with zidovudine phosphorylation in vitro
    • 29. Hoggard PG, Veal GJ, Wild MJ. Drug interactions with zidovudine phosphorylation in vitro. Antimicrob Agents Chemother 1995, 39:1376-1378.
    • (1995) Antimicrob Agents Chemother , vol.39 , pp. 1376-1378
    • Hoggard, P.G.1    Veal, G.J.2    Wild, M.J.3
  • 30
    • 0029549244 scopus 로고
    • Alteration in thymidine kinase activity in cells treated with an antiviral agent
    • 30. Turriziani O, Antonelli C, Verri A, et al. Alteration in thymidine kinase activity in cells treated with an antiviral agent. J Biol Regul Homeost Agents 1995, 9:47-51.
    • (1995) J Biol Regul Homeost Agents , vol.9 , pp. 47-51
    • Turriziani, O.1    Antonelli, C.2    Verri, A.3
  • 31
    • 16044371941 scopus 로고
    • Decreased activation of zidovudine (AZT) in peripheral blood lymphocytes from patients with AIDS chronically treated with AZT
    • Florence, June [TH.B.36]
    • 31. Hill MD, Miles S, Gomperts E, et al. Decreased activation of zidovudine (AZT) in peripheral blood lymphocytes from patients with AIDS chronically treated with AZT. VII International Conference on AIDS, Florence, June 1991 [TH.B.36].
    • (1991) VII International Conference on AIDS
    • Hill, M.D.1    Miles, S.2    Gomperts, E.3
  • 32
    • 0027135249 scopus 로고
    • Evidence of in vitro development of drug resistance to azidothymidine in T lymphocytic leukemia cell lines (Jurkat E6-1/AZT 100) and in pediatric patients with HIV-1 infection
    • 32. Avramis VI, Kwock R, Solozano MM, et al. Evidence of in vitro development of drug resistance to azidothymidine in T lymphocytic leukemia cell lines (Jurkat E6-1/AZT 100) and in pediatric patients with HIV-1 infection. J Acquir Immune Defic Syndr 1993, 6:1287-1296.
    • (1993) J Acquir Immune Defic Syndr , vol.6 , pp. 1287-1296
    • Avramis, V.I.1    Kwock, R.2    Solozano, M.M.3
  • 33
    • 0029768927 scopus 로고    scopus 로고
    • The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites
    • 33. Barry MG, Khoo SH, Veal GJ, et al. The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites. AIDS 1996, 10:1361-1367.
    • (1996) AIDS , vol.10 , pp. 1361-1367
    • Barry, M.G.1    Khoo, S.H.2    Veal, G.J.3
  • 34
    • 0028308785 scopus 로고
    • Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers
    • 34. Barry M, Wild M, Veal G, et al. Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers. AIDS 1994, 8:F1-F5.
    • (1994) AIDS , vol.8
    • Barry, M.1    Wild, M.2    Veal, G.3
  • 35
    • 0027979332 scopus 로고
    • Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells
    • 35. Robbins BL, Rodman J, McDonald C, et al. Enzymatic assay for measurement of zidovudine triphosphate in peripheral blood mononuclear cells. Antimicrob Agents Chemother 1994, 38:115-121.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 115-121
    • Robbins, B.L.1    Rodman, J.2    McDonald, C.3
  • 36
    • 0029909226 scopus 로고    scopus 로고
    • Zidovudine phosphorylation after short-term and long-term therapy with zidovudine in patients infected with human immunodeficiency virus
    • 36. Peter K, Gambertoglio JG. Zidovudine phosphorylation after short-term and long-term therapy with zidovudine in patients infected with human immunodeficiency virus. Clin Pharmacol Ther 1996, 60:168-176.
    • (1996) Clin Pharmacol Ther , vol.60 , pp. 168-176
    • Peter, K.1    Gambertoglio, J.G.2
  • 37
    • 0003321395 scopus 로고    scopus 로고
    • Treatment with indinavir (IDV), zidovudine (ZDV), and lamivudine (3TC): Three-year follow-up
    • Chicago, January-February [abstract 388]
    • 37. Gulick R, Mellors J, Havlir D, et al. Treatment with indinavir (IDV), zidovudine (ZDV), and lamivudine (3TC): three-year follow-up. Sixth Conference on Retroviruses and Opportunistic Infections. Chicago, January-February 1999 [abstract 388].
    • (1999) Sixth Conference on Retroviruses and Opportunistic Infections
    • Gulick, R.1    Mellors, J.2    Havlir, D.3
  • 38
    • 0028232638 scopus 로고
    • Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virus
    • 38. Stretcher BN, Pesce AJ, Frame PT, et al. Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virus. Antimicrob Agents Chemother 1994, 38:1541-1547.
    • (1994) Antimicrob Agents Chemother , vol.38 , pp. 1541-1547
    • Stretcher, B.N.1    Pesce, A.J.2    Frame, P.T.3
  • 39
    • 0026742359 scopus 로고
    • Pharmacokinetics of zidovudine phosphorylation in patients with the human immunodeficiency virus
    • 39. Stretcher BN, Pesce AJ, Hurtubise PE, et al. Pharmacokinetics of zidovudine phosphorylation in patients with the human immunodeficiency virus. Ther Drug Monit 1992, 14:281-285.
    • (1992) Ther Drug Monit , vol.14 , pp. 281-285
    • Stretcher, B.N.1    Pesce, A.J.2    Hurtubise, P.E.3
  • 40
    • 0025743488 scopus 로고
    • Concentrations of phosphorylated zidovudine (ZDV) in patient leukocytes do not correlate with ZDV dose or plasma concentrations
    • 40. Stretcher BN, Pesce AJ, Murray JA, et al. Concentrations of phosphorylated zidovudine (ZDV) in patient leukocytes do not correlate with ZDV dose or plasma concentrations. Trier Drug Monit 1991, 13:325-331.
    • (1991) Trier Drug Monit , vol.13 , pp. 325-331
    • Stretcher, B.N.1    Pesce, A.J.2    Murray, J.A.3
  • 41
    • 0028997078 scopus 로고
    • A phase I/II study of 2′-deoxy-3′-thiacytidine (lamivudine) in patients with advanced human immunodeficiency virus infection
    • 41. Pluda JM, Cooley TP, Montaner JSG, et al. A phase I/II study of 2′-deoxy-3′-thiacytidine (lamivudine) in patients with advanced human immunodeficiency virus infection. J Infect Dis 1995; 171:1438-1447.
    • (1995) J Infect Dis , vol.171 , pp. 1438-1447
    • Pluda, J.M.1    Cooley, T.P.2    Montaner, J.S.G.3
  • 42
    • 84920357601 scopus 로고    scopus 로고
    • Videx (didanosine)
    • Edited by Westley GJ. Montvale, New Jersey: Medical Economics Company, Inc.
    • nd Edn. Edited by Westley GJ. Montvale, New Jersey: Medical Economics Company, Inc., 1998:768-772.
    • (1998) nd Edn. , pp. 768-772
  • 43
    • 0024405549 scopus 로고
    • Cellular pharmacology of 2′,3′-dideoxy-2′,3′-didehydrothymidine, a nucleoside analog actively inhibits against human immunodeficiency virus
    • 43. Ho HT, Hitchcock MJM. Cellular pharmacology of 2′,3′-dideoxy-2′,3′-didehydrothymidine, a nucleoside analog actively inhibits against human immunodeficiency virus. Antimicrob Agents Chemother 1989, 33:844-849.
    • (1989) Antimicrob Agents Chemother , vol.33 , pp. 844-849
    • Ho, H.T.1    Hitchcock, M.J.M.2
  • 44
    • 0025344520 scopus 로고
    • Cellular phar′ macology of 2′,3′-didehydro-2′,3′-dideoxythymidine (D4T) in human peripheral blood mononuclear cells
    • 44. Zhu Z, Ho HT, Hitchcock MJ, Sommadossi J-P. Cellular phar′ macology of 2′,3′-didehydro-2′,3′-dideoxythymidine (D4T) in human peripheral blood mononuclear cells. Biochem Pharmacol 1990, 39:R14-R19.
    • (1990) Biochem Pharmacol , vol.39
    • Zhu, Z.1    Ho, H.T.2    Hitchcock, M.J.3    Sommadossi, J.-P.4
  • 45
    • 0022996630 scopus 로고
    • Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase
    • 45. Furman PA, Fyfe JA, St Clair MH, et al. Phosphorylation of 3′-azido-3′-deoxythymidine and selective interaction of the 5′-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci USA 1986, 83:8333-8337.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8333-8337
    • Furman, P.A.1    Fyfe, J.A.2    St. Clair, M.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.